The long-term consequences of antibiotic therapy: Role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

(2018) Nicholas A. Scott et al.   Science Translational Medicine

Antibiotic Use and New-Onset Inflammatory Bowel Disease in Olmsted County, Minnesota: A Population-Based Case-Control Study

(2017) Satimai Aniwan et al.   Journal of Crohns & Colitis

Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity

(2016) Frank I. Scott et al.   GASTROENTEROLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration

(2016) C. A. Lopez et al.   SCIENCE

Antibiotic use and its consequences for the normal microbiome

(2016) Martin J. Blaser   SCIENCE

G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation

(2016) Marjon E. Kamp et al.   PLoS One

Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids

(2016) Xiaoya Zhao et al.   PLoS One

Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists

(2016) Zhiwei Ang et al.   Scientific Reports

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Determining the Long-term Effect of Antibiotic Administration on the Human Normal Intestinal Microbiota Using Culture and Pyrosequencing Methods

(2015) Mamun-Ur Rashid et al.   CLINICAL INFECTIOUS DISEASES

Food, Immunity, and the Microbiome

(2015) Herbert Tilg et al.   GASTROENTEROLOGY

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

(2015) Kathryn A Knoop et al.   GUT

Patterns of Antibiotic Exposure and Clinical Disease Activity in Inflammatory Bowel Disease

(2015) Jana G. Hashash et al.   INFLAMMATORY BOWEL DISEASES

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

(2015) M.K. Nøhr et al.   NEUROSCIENCE

Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case-Control Study

(2015) D. B. Horton et al.   PEDIATRICS

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

(2015) Angélica T. Vieira et al.   Arthritis & Rheumatology

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

(2015) Fabiana Andréa Moura et al.   Redox Biology

Maternal Antibiotic-Induced Early Changes in Microbial Colonization Selectively Modulate Colonic Permeability and Inducible Heat Shock Proteins, and Digesta Concentrations of Alkaline Phosphatase and TLR-Stimulants in Swine Offspring

(2015) Marie-Edith Arnal et al.   PLoS One

Antibiotic Treatment Affects Intestinal Permeability and Gut Microbial Composition in Wistar Rats Dependent on Antibiotic Class

(2015) Monica Vera-Lise Tulstrup et al.   PLoS One

The effects of the microbiota on the host immune system

(2014) Jacek Karczewski et al.   AUTOIMMUNITY

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Both butyrate incubation and hypoxia upregulate genes involved in the ruminal transport of SCFA and their metabolites

(2014) F. Dengler et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Constitutive expression of MMP9 in intestinal epithelium worsens murine acute colitis and is associated with increased levels of proinflammatory cytokine Kc

(2013) Hongchun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Antibiotic exposure and the development of coeliac disease: a nationwide case–control study

(2013) Karl Mårild et al.   BMC GASTROENTEROLOGY

Energy, Oxidative Stress, and Inflammation in the Colon

(2013) Richard F. Harty   DIGESTIVE DISEASES AND SCIENCES

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

G Protein-Coupled Receptor 43 Moderates Gut Inflammation Through Cytokine Regulation from Mononuclear Cells

(2013) Ryuta Masui et al.   INFLAMMATORY BOWEL DISEASES

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Extracellular signal-regulated kinase plays a proapoptotic role in podocytes after reactive oxygen species treatment and inhibition of integrin–extracellular matrix interaction

(2012) Chien-An Chen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Gut microbiota disturbance during antibiotic therapy: a multi-omic approach

(2012) Ana Elena Pérez-Cobas et al.   GUT

Antibiotic Exposure and IBD Development Among Children: A Population-Based Cohort Study

(2012) M. P. Kronman et al.   PEDIATRICS

Association Between the Use of Antibiotics and New Diagnoses of Crohn's Disease and Ulcerative Colitis

(2011) Souradet Y Shaw et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to ExacerbatedCitrobacter rodentium-Induced Colitis

(2011) M. Wlodarska et al.   INFECTION AND IMMUNITY

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice

(2011) Ganna Tolstanova et al.   LABORATORY INVESTIGATION

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia

(2011) Tanya Hartney et al.   PLoS One

Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease

(2010) Motoyuki Otsuka et al.   GASTROENTEROLOGY

Antibiotic use and inflammatory bowel diseases in childhood

(2010) A. Hviid et al.   GUT

Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis

(2010) Stuart F. W. Kendrick et al.   HEPATOLOGY

G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer

(2010) Yong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Long-term impacts of antibiotic exposure on the human intestinal microbiota

(2010) C. Jernberg et al.   MICROBIOLOGY-SGM

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways

(2009) Muriel Larauche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis

(2009) Pallavi Garg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation

(2009) D. A. Antonopoulos et al.   INFECTION AND IMMUNITY

Butyrate utilization by the colonic mucosa in inflammatory bowel diseases

(2009) Ronan Thibault et al.   INFLAMMATORY BOWEL DISEASES

Colonic Gene Expression in Conventional and Germ-Free Mice with a Focus on the Butyrate Receptor GPR109A and the Butyrate Transporter SLC5A8

(2009) Gail A. Cresci et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Mesalamine Restores Angiogenic Balance in Experimental Ulcerative Colitis by Reducing Expression of Endostatin and Angiostatin: Novel Molecular Mechanism for Therapeutic Action of Mesalamine

(2009) X. Deng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

(2009) Christine J Weydert et al.   Nature Protocols

Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer

(2008) Muthusamy Thangaraju et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS