Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits

Mitochondria in cancer metabolism, an organelle whose time has come?

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Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells

(2018) Lara Gibellini et al.   Frontiers in Oncology

AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts

(2017) Miguel Sanchez-Alvarez et al.   Scientific Reports

The Warburg effect: 80 years on

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Emerging role of Lon protease as a master regulator of mitochondrial functions

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Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Mitochondria and Cancer

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Regulators of mitochondrial dynamics in cancer

(2016) Daniela Senft et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders

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A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria

(2016) Kenneth Robert Pryde et al.   Cell Reports

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

(2016) Jae Ho Seo et al.   PLOS BIOLOGY

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer

(2015) Marcello Pinti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

(2015) Jagadish C. Ghosh et al.   JNCI-Journal of the National Cancer Institute

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Lon regulates apoptosis through the association with Hsp60–mtHsp70 complex

(2015) T-Y Kao et al.   Cell Death & Disease

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

(2015) Jagadish C. Ghosh et al.   JNCI-Journal of the National Cancer Institute

LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

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Dynamics of the ClpP serine protease: A model for self-compartmentalized proteases

(2014) Kaiyin Liu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

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ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

(2014) Pedro M. Quirós et al.   Cell Reports

Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells

(2013) Salil P. Desai et al.   BIOPHYSICAL JOURNAL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

(2013) E. F. Vieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of the mitochondrial Hsp90 metabolome in tumours

(2013) Young Chan Chae et al.   Nature Communications

Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis

(2012) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

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Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

(2010) Sun-Shin Cha et al.   EMBO JOURNAL

The mitochondrial UPR - protecting organelle protein homeostasis

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The Akt isoforms are present at distinct subcellular locations

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Adapting Proteostasis for Disease Intervention

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