期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 14, 页码 2463-2472出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1177-0
关键词
Apoptosis; Autophagy; Hsp90; Mitochondrial permeability transition; Tumor progression
资金
- National Institutes of Health [CA140043, CA78810, CA118005]
Although essential for energy production and cell fate decisions, the mechanisms that govern protein homeostasis, or proteostasis, in mitochondria are only recently beginning to emerge. Fresh experimental evidence has uncovered a role of molecular chaperones of the heat shock protein 90 (Hsp90) family in overseeing the protein folding environment in mitochondria. Initially implicated in protection against cell death, there is now evidence that Hsp90-directed protein quality control in mitochondria connects to hosts of cellular homeostatic networks that become prominently exploited in human cancer.
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