Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells

(2015) Bilal Rah et al.   Autophagy

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell

(2015) Mayuko Nishi et al.   Oncotarget

Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells

(2014) Yosuke Shimodaira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells

(2014) Han Min et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Regulation of autophagy by the Rab GTPase network

(2014) X Ao et al.   CELL DEATH AND DIFFERENTIATION

β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

(2014) E J Park et al.   Cell Death & Disease

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

(2013) Avani R. Vyas et al.   AAPS Journal

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells

(2013) Tianliang Li et al.   Autophagy

Recent progress in pancreatic cancer

(2013) Christopher L. Wolfgang et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Autophagy Fails to Alter Withaferin A-Mediated Lethality in Human Breast Cancer Cells

(2013) Eun-Ryeong Hahm et al.   CURRENT CANCER DRUG TARGETS

Targeting the ubiquitin–proteasome system for cancer therapy

(2013) Min Shen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Therapeutic Advances in Pancreatic Cancer

(2013) Andrew Scott Paulson et al.   GASTROENTEROLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Targeting endoplasmic reticulum signaling pathways in cancer

(2012) Fabio Martinon   ACTA ONCOLOGICA

A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers

(2012) Stephanie M. Cohen et al.   AMERICAN JOURNAL OF SURGERY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

(2012) Axel H. Schönthal   BIOCHEMICAL PHARMACOLOGY

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

(2012) Miranda Y. Fong et al.   PLoS One

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

(2012) Saad Khan et al.   PLoS One

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

(2011) Min Jung Choi et al.   TOXICOLOGY IN VITRO

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

(2011) R Russo et al.   Cell Death & Disease

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Proteasome system of protein degradation and processing

(2010) A. V. Sorokin et al.   BIOCHEMISTRY-MOSCOW

Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: Crosstalk among proteasome, autophagy-lysosome and ER stress

(2010) Miyazawa   INTERNATIONAL JOURNAL OF ONCOLOGY

Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)

(2010) Hedy Lee Kindler et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo

(2008) S. D. Stan et al.   CANCER RESEARCH

Preferential Cytotoxicity of Bortezomib toward Hypoxic Tumor Cells via Overactivation of Endoplasmic Reticulum Stress Pathways

(2008) D. R. Fels et al.   CANCER RESEARCH

Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells

(2008) Huanjie Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION