Article
Biochemistry & Molecular Biology
Fernando Toshio Ogata, Alex Yuri Simoes Sato, Lucia Coppo, Roberto Jun Arai, Arnold Ira Stern, Hugo Pequeno Monteiro
Summary: The epithelial/mesenchymal transition (EMT) is associated with tumor metastasis. Cancer cells have high levels of antioxidants, such as the Trx/TrxR and GSH/Grx systems, to counteract oxidative and nitrosative stress. These systems play a significant role in EMT signaling and cancer cell progression.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Endocrinology & Metabolism
Jennifer S. Stancill, John A. Corbett
Summary: Oxidative stress is implicated in pancreatic beta-cell damage in type 1 and type 2 diabetes, potentially leading to dysfunction and death of beta cells. Beta cells are vulnerable to oxidative damage but have high expression of antioxidant enzymes which may help maintain their function and survival.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Manuel J. Mallen-Ponce, Maria Jose Huertas, Francisco J. Florencio
Summary: This study focuses on the evolutionary diversity of Trx systems in cyanobacteria and their phylogenetic relationships, as well as the physiological relevance of redox regulation in cyanobacteria. The results reveal variations in Trx systems among different cyanobacteria and gradual loss of certain proteins with cyanobacterial diversification.
Article
Biochemistry & Molecular Biology
Dongzhu Duan, Yanru Wang, Dabo Pan, Le Wang, Jian Xiao, Peng Song, Xiaojie Jin, Xiaoling Wang
Summary: DET targets TrxR and inhibits its activity, leading to cancer cell apoptosis through oxidative stress. Down-regulation of TrxR1 by shRNA increases cell sensitivity to DET. Targeting of TrxR1 by DET reveals a novel mechanism of action and enhances the potential of DET as a chemotherapeutic agent for cancers.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ausra Nemeikaite-Ceniene, Lina Miseviciene, Audrone Maroziene, Violeta Jonusiene, Narimantas Cenas
Summary: NADPH: thioredoxin reductase (TrxR) is a potential target for anticancer agents. In this study, the single-electron reduction potentials of TrxR inhibitors were calculated, and their cytotoxicity was compared with that of nitroaromatics. The results suggest that TrxR inhibition may contribute to the enhanced cytotoxicity of the inhibitors, and other factors such as reactions with cytochromes P-450 and glutathione reductase may also play a role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shoujiao Peng, Shaopeng Yu, Junmin Zhang, Jiange Zhang
Summary: 6-Shogaol, a bioactive compound in ginger, is a novel thioredoxin reductase (TrxR) inhibitor that induces oxidative-stress-mediated apoptosis in HeLa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Yuanyuan Li, Qun Tang, Yu Xie, Dian He, Kun Yang, Lifang Zheng
Summary: Targeting specific mitochondrial alterations to kill cancer cells while sparing normal cells is a promising strategy. Mitocoumarins, particularly compound 15b, have shown potential as anti-breast cancer agents by suppressing cell growth in cancer cells while minimizing toxicity to normal cells. Compound 15b may be developed into a mitochondria-targeted drug for triple negative breast cancer treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Mojca Trstenjak Prebanda, Petra Matjan-Stefin, Boris Turk, Natasa Kopitar-Jerala
Summary: The study investigated the impact of lipopolysaccharide-triggered neuroinflammation on the protein levels of redox-sensitive proteins in the brain and cerebella of Stefin B-deficient mice. The results suggest a role of oxidative stress in the progression of the disease.
Article
Biochemistry & Molecular Biology
Kaelyn A. Jenny, Gracyn Mose, Daniel J. Haupt, Robert J. Hondal
Summary: Ergothioneine (EGT), a potent antioxidant, can be reduced by the selenoenzyme mammalian thioredoxin reductase (Sec-TrxR). The glutathione system is more efficient in reducing oxidized forms of EGT, but Sec-TrxR has the advantage of directly reducing both ESSE and 5-oxo-EGT. This discovery provides insights into the redox biology of EGT and warrants further investigation.
Article
Environmental Sciences
Debarati Chanda, William Dudefoi, Joshua Anadu, Matteo Minghetti
Summary: The study found that AgNO3 or cit-AgNP can inhibit the activity of selenoenzymes without inducing oxidative stress in RTgutGC cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Pharmacology & Pharmacy
Radosveta Gencheva, Elias S. J. Arner
Summary: Cytosolic selenoprotein thioredoxin reductase 1 (TrxR1) and mitochondrial TrxR2 (TXNRD2) can be inhibited by a wide range of electrophilic compounds, which may have important implications for cancer therapy.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinjing Jia, Guangtao Xu, Dongsheng Zhu, Hongjun Liu, Xiansi Zeng, Li Li
Summary: This review highlights the significance of the thioredoxin system in CNS diseases and suggests that it may be a promising therapeutic target. The article also proposes future directions for research in developing effective inducers of Trx and specific inhibitors of TXNIP for the treatment of CNS diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Immunology
Naveen Thakur, Amar Nath Sharma, Mangesh Dattu Hade, Ajay Chhaya, Ashwani Kumar, Ravinder Singh Jolly, Kanak L. Dikshit
Summary: This study reveals that Mycobacterium tuberculosis produces an unconventional flavohemoglobin (MtbFHb) that can change its conformation and reduce mycothiol disulfide in the presence of D-lactate, protecting the cell from oxidative damage. Overexpression of MtbFHb in M. smegmatis significantly reduces lipid peroxidation and enhances cell survival under oxidative stress.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Lin Hong, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou
Summary: The study identified a synergistic lethal interaction between mTOR and TrxR inhibitors, triggering oxidative stress and activating multiple signaling pathways to induce cancer cell death. The combination of Auranofin and Everolimus showed promising efficacy in suppressing tumor growth with minimal toxicity, suggesting a potential therapeutic strategy for cancer treatment.
Article
Multidisciplinary Sciences
Jia Liu, Jin Huang, Hu Liu, Chang Chen, Jianying Xu, Liangwei Zhong
Summary: The study found dynamically increased 4HNE-protein adducts and decreased Trx1 levels in the serum of AECOPD patients, which are closely related to the pathological processes of the disease. This provides a new basis for the use of antioxidant drugs in AECOPD patients.
Article
Biochemistry & Molecular Biology
Bareun Kim, Ruoxuan Sun, Wonkyung Oh, Alyssa Min Jung Kim, Johann Richard Schwarz, Seung-Oe Lim
MOLECULAR CARCINOGENESIS
(2020)
Article
Pharmacology & Pharmacy
Xiao-Xiao Li, Lin Zhuo, Yan Zhang, Yi-Heng Yang, Hong Zhang, Si-Yan Zhan, Suo-Di Zhai
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Xiao-xiao Li, Si-qian Zheng, Jia-hui Gu, Tao Huang, Fang Liu, Qing-gang Ge, Bin Liu, Chao Li, Min Yi, You-fa Qin, Rong-sheng Zhao, Lu-wen Shi
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Chuhui Wang, Xiaoxiao Li, Chao Li, Na He, Qinggang Ge, Suodi Zhai
Summary: This case study demonstrated that vancomycin can rapidly penetrate into abdominal tissue in acceptable amounts, with about 76% of the drug moving into abdominal drainage fluid for SAP patients within 30 minutes.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Xiao-xiao Li, Yin-chu Cheng, Suo-di Zhai, Peng Yao, Si-yan Zhan, Lu-wen Shi
Summary: The study aims to determine the risk of liver injury associated with the use of different intravenous lipid emulsions (LEs) in large populations in China. The results show a significant association between LEs use and liver injury, with differences in risk among various LEs requiring further evaluation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Ruoxuan Sun, Alyssa Min Jung Kim, Seung-Oe Lim
Summary: Evasion of host immune surveillance is a hallmark of cancer, and immune checkpoint therapy aims to eliminate cancer progression by reprogramming the antitumor immune response. Understanding the impact of protein glycosylation on immune function will drive the rational development of future cancer diagnostics and therapeutic strategies.
Article
Biochemistry & Molecular Biology
Ruoxuan Sun, Seung-Oe Lim
Summary: This study reveals a novel mechanism for the regulation of 4-1BB at the protein level, involving polyubiquitination and degradation via the ubiquitin-proteasomal system. These findings may provide guidance for the development of targeted therapies for cancer and other immune disorders.
Article
Cell Biology
Ruoxuan Sun, Alyssa Min Jung Kim, Allison A. Murray, Seung-Oe Lim
Summary: This study systematically evaluated the impact of N-glycosylation on the behavior and regulation of 4-1BB. The results showed that N-glycosylation prevents the oligomerization of 4-1BB, allowing its membrane transportation and turnover, thus modulating the protein's abundance and function.
Article
Cell Biology
Hang-yu Chen, Xiao-xiao Li, Chao Li, Hai-chuan Zhu, Hong-yan Hou, Bo Zhang, Li-ming Cheng, Hui Hu, Zhong-xin Lu, Jia-xing Liu, Ze-ruo Yang, Lei Zhang, Nuo Xu, Long Chen, Chuan He, Chao-ran Dong, Qing-gang Ge, Jian Lin
Summary: This study demonstrates the utility of 5hmC as an accurate early warning marker for disease progression and myocardial injury in patients with COVID-19. It also identifies phosphodiesterase 4D and ten-eleven translocation 2 as potential important markers for the progression of COVID-19 disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Infectious Diseases
Chuhui Wang, Chao Zhang, Xiaoxiao Li, Sixuan Zhao, Na He, Suodi Zhai, Qinggang Ge
Summary: The study aimed to determine factors affecting pharmacokinetic profiles and optimal dosage regimens for critically ill patients undergoing CVVH. A two-compartment model with first-order elimination characterized vancomycin pharmacokinetics, with CL significantly correlated with UFR and albumin level. Recommended dosage regimens varied based on UFR and albumin levels, providing guidance for clinicians in choosing the optimal vancomycin dosage for these patients.
Article
Microbiology
Xiao-Xiao Li, Chao Li, Peng-Cheng Du, Shao-Yun Li, Le Yu, Zhi-Qiang Zhao, Ting-Ting Liu, Cong-Kai Zhang, Sen-Chao Zhang, Yu Zhuang, Chao-Ran Dong, Qing-Gang Ge
Summary: This study evaluated the performance of nanopore amplicon sequencing in detecting SARS-CoV-2 in clinical samples. The results showed that the NAS method had high sensitivity and specificity compared with RT-qPCR. The sequencing results can also be used to indicate viral load and display the dynamics of infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Xiaoxiao Li, Chao Li, Yang Zhou, Zhengqian Li, Xin Xiong, Chuhui Wang, Congya Zhou, Bin Han, Li Yang, Xiangyang Guo
Summary: This article reports a case of a 14-year-old Chinese boy who developed malignant hyperthermia (MH) during cervical spine surgery. The researchers used dantrolene, continuous veno-venous hemofiltration (CVVH), and plasma exchange (PE) therapy, and studied the pharmacokinetics of dantrolene during PE treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Xiao-xiao Li, Guan-ru Wang, Chao Li, Na He, Peng Yao, Yin-chu Cheng, Chu-hui Wang, Qing-gang Ge, Min Yi, Zong-yu Wang, Lu-wen Shi, Rong-sheng Zhao
Summary: Thrombocytopenia can have severe consequences in critically ill patients, with drug-induced thrombocytopenia (DITP) being an important factor. In this case, severe thrombocytopenia during ICU hospitalization was likely associated with vancomycin. By understanding the process of identifying DITP and reviewing clinical studies, a risk alert for vancomycin-related severe hematotoxicity should be considered.
FRONTIERS IN MEDICINE
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Xiao-Xiao Li, Yin-Chu Cheng, Suo-Di Zhai, Peng Yao, Si-Yan Zhan, Luwen Shi
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Letter
Medicine, General & Internal
Xiaoxiao Li, Na He, Suodi Zhai, Luwen Shi
