Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
出版年份 2019 全文链接
标题
Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
作者
关键词
Hepatocellular carcinoma, Macrophages, Myeloid suppressor cells, Immunotherapy
出版物
Molecular Cancer
Volume 18, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-08-29
DOI
10.1186/s12943-019-1047-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Therapeutic advances for patients with intermediate hepatocellular carcinoma
- (2019) Jin-Yu Sun et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
- (2019) Xianjie Jiang et al. Molecular Cancer
- The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
- (2019) Bing Liu et al. Nature Communications
- Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patients
- (2019) Emeric Limagne et al. OncoImmunology
- Macrophage Origin, Metabolic Reprogramming and IL-1 Signaling: Promises and Pitfalls in Lung Cancer
- (2019) Emma Guilbaud et al. Cancers
- Targeting immune cells for cancer therapy
- (2019) Sin Yee Gun et al. Redox Biology
- Novel immunotherapeutic approaches for hepatocellular carcinoma treatment
- (2019) Davide Busato et al. Expert Review of Clinical Pharmacology
- Molecular model linking Th2 polarized M2 tumour‐associated macrophages with deaminase‐mediated cancer progression mutation signatures
- (2019) Jared Mamrot et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Blocking TREM-1+ Tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-PD-L1 resistance in liver cancer
- (2019) Qinchuan Wu et al. HEPATOLOGY
- Living Donor Liver Transplantation for Hepatocellular Carcinoma: An Asian Perspective
- (2019) Young-In Yoon et al. DIGESTIVE DISEASES AND SCIENCES
- Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion
- (2019) Dong Wang et al. CANCER LETTERS
- A Positive Feedback Loop Between Cancer Stem‐Like Cells and Tumor‐Associated Neutrophils Controls Hepatocellular Carcinoma Progression
- (2019) Shao‐Lai Zhou et al. HEPATOLOGY
- Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma
- (2019) Yohei Mano et al. JOURNAL OF GASTROENTEROLOGY
- Targeting Tumor-Associated Macrophages in Cancer
- (2019) Paulina Pathria et al. TRENDS IN IMMUNOLOGY
- Tumor-associated macrophages: role in cancer development and therapeutic implications
- (2019) Arash Salmaninejad et al. CELLULAR ONCOLOGY
- PPARα Suppresses PD-L1-Mediated Immune Escape by Down-regulating SPP1 in Human Hepatocellular Carcinoma
- (2019) Guoliang Wang et al. Cancer Research and Treatment
- Myeloid-Derived Suppressor Cells: Ductile Targets in Disease
- (2019) Francesca Maria Consonni et al. Frontiers in Immunology
- Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
- (2019) Antonino Bruno et al. Frontiers in Immunology
- Keratin 19 Expression in Hepatocellular Carcinoma Is Regulated by Fibroblast-Derived HGF via a MET-ERK1/2-AP1 and SP1 Axis
- (2018) Hyungjin Rhee et al. CANCER RESEARCH
- Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma
- (2018) Christine Haider et al. HEPATOLOGY
- Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation
- (2018) Sifan Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma
- (2018) Yusheng Cheng et al. Cell Death & Disease
- Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC
- (2018) Jie Ji et al. Cell Death & Disease
- Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors
- (2018) Yang Yang et al. Cell Death & Disease
- OX40 expression in hepatocellular carcinoma is associated with a distinct immune microenvironment, specific mutation signature, and poor prognosis
- (2018) Kunlin Xie et al. OncoImmunology
- STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells
- (2018) Prajna Guha et al. ONCOGENE
- TGF-β secreted by tumor-associated macrophages promotes proliferation and invasion of colorectal cancer via miR-34a-VEGF axis
- (2018) Danhua Zhang et al. CELL CYCLE
- Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts
- (2018) Yuan Zhou et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling
- (2018) Yawen Li et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Recruited bone marrow derived cells, local stromal cells and IL-17 at the front line of resistance development to anti-VEGF targeted therapies
- (2018) Behrad Darvishi et al. LIFE SCIENCES
- An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
- (2018) Hanyong Sun et al. Nature Communications
- A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment
- (2018) Yu-Tzu Liu et al. Journal for ImmunoTherapy of Cancer
- Interactions between interleukin-6 and myeloid-derived suppressor cells drive the chemoresistant phenotype of hepatocellular cancer
- (2017) Min Xu et al. EXPERIMENTAL CELL RESEARCH
- Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas
- (2017) Guoying Zhou et al. GASTROENTEROLOGY
- Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
- (2017) Jingying Zhou et al. GUT
- Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model
- (2017) Guangfu Li et al. JOURNAL OF HEPATOLOGY
- Neutrophils as active regulators of the immune system in the tumor microenvironment
- (2017) Merav E. Shaul et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma
- (2017) Jian-Yang Ao et al. MOLECULAR CANCER THERAPEUTICS
- Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
- (2017) David Kung-Chun Chiu et al. Nature Communications
- A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer
- (2017) Wenbo Yao et al. EBioMedicine
- Transradial Approach for Hepatic Radioembolization: Initial Results and Technique
- (2016) Vivian L. Bishay et al. AMERICAN JOURNAL OF ROENTGENOLOGY
- A Breakthrough: Macrophage-Directed Cancer Immunotherapy
- (2016) C. D. Mills et al. CANCER RESEARCH
- Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
- (2016) Shao-Lai Zhou et al. GASTROENTEROLOGY
- Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26
- (2016) David Kung-Chun Chiu et al. HEPATOLOGY
- Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells
- (2016) Renxiong Wei et al. IMMUNOLOGY AND CELL BIOLOGY
- Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model
- (2016) Kun-Yu Teng et al. MOLECULAR CANCER THERAPEUTICS
- CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia
- (2016) Alexander Semaan et al. VIRCHOWS ARCHIV
- Regulatory T cells, especially ICOS+ FOXP3+ regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival
- (2016) Jian-Fei Tu et al. Scientific Reports
- Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation
- (2016) J-t Cheng et al. Oncogenesis
- The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation
- (2016) Kankana Bardhan et al. Frontiers in Immunology
- PD-L1+MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment
- (2016) Tomoaki Iwata et al. Scientific Reports
- The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis
- (2015) Caecilia Hapsari Ceriapuri Sukowati et al. BMC CANCER
- TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression
- (2015) S. Li et al. CANCER RESEARCH
- Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
- (2015) Xiaoguang Li et al. GUT
- Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human
- (2015) Lisa Andzinski et al. INTERNATIONAL JOURNAL OF CANCER
- CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
- (2015) Li Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature
- (2015) Elena I. Deryugina et al. MATRIX BIOLOGY
- Delivery of siRNA Using CXCR4-targeted Nanoparticles Modulates Tumor Microenvironment and Achieves a Potent Antitumor Response in Liver Cancer
- (2015) Jia-Yu Liu et al. MOLECULAR THERAPY
- GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cellsex vivo
- (2015) Alexander Pedroza-Gonzalez et al. OncoImmunology
- Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
- (2015) Yosuke Osawa et al. EBioMedicine
- Transforming Growth Factor- as a Therapeutic Target in Hepatocellular Carcinoma
- (2014) G. Giannelli et al. CANCER RESEARCH
- Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells
- (2014) Shanshan Wan et al. GASTROENTEROLOGY
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Role of estrogen in hepatocellular carcinoma: is inflammation the key?
- (2014) Liang Shi et al. Journal of Translational Medicine
- mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma
- (2014) Kimberly J Riehle et al. MODERN PATHOLOGY
- CXCL17 Expression Predicts Poor Prognosis and Correlates with Adverse Immune Infiltration in Hepatocellular Carcinoma
- (2014) Li Li et al. PLoS One
- Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation
- (2013) Chih-Peng Chang et al. Autophagy
- Role of Macrophage Targeting in the Antitumor Activity of Trabectedin
- (2013) Giovanni Germano et al. CANCER CELL
- Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
- (2013) S. Kalathil et al. CANCER RESEARCH
- SSAO inhibitors suppress hepatocellular tumor growth in mice
- (2013) Rui Li et al. CELLULAR IMMUNOLOGY
- Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma
- (2013) Yanmei Han et al. HEPATOLOGY
- Tumor associated macrophages and neutrophils in cancer
- (2013) Maria Rosaria Galdiero et al. IMMUNOBIOLOGY
- Sorafenib relieves cell-intrinsic and cell-extrinsic inhibitions of effector T cells in tumor microenvironment to augment antitumor immunity
- (2013) Mei-Ling Chen et al. INTERNATIONAL JOURNAL OF CANCER
- A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
- (2013) Bruno Sangro et al. JOURNAL OF HEPATOLOGY
- Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats
- (2013) Norio Kubo et al. LIVER INTERNATIONAL
- CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma
- (2012) Q. Gao et al. CANCER RESEARCH
- Impairment of CD4+cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma
- (2012) Junliang Fu et al. HEPATOLOGY
- Estrogen Represses Hepatocellular Carcinoma (HCC) Growth via Inhibiting Alternative Activation of Tumor-associated Macrophages (TAMs)
- (2012) Weiwei Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Macrophage plasticity and polarization: in vivo veritas
- (2012) Antonio Sica et al. JOURNAL OF CLINICAL INVESTIGATION
- Sorafenib reduces hepatic infiltrated regulatory T cells in hepatocellular carcinoma patients by suppressing TGF-beta signal
- (2012) Quanrongzi Wang et al. JOURNAL OF SURGICAL ONCOLOGY
- TIM3 gene polymorphisms in patients with chronic hepatitis B virus infection: impact on disease susceptibility and hepatocellular carcinoma traits
- (2012) Z. Li et al. TISSUE ANTIGENS
- Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
- (2011) Tuanjie Li et al. CANCER LETTERS
- Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects
- (2010) W. Zhang et al. CLINICAL CANCER RESEARCH
- Up-regulated myeloid-derived suppressor cell contributes to hepatocellular carcinoma development by impairing dendritic cell function
- (2010) Cheng-En Hu et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
- (2009) Zvi G. Fridlender et al. CANCER CELL
- Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions
- (2009) K. Wu et al. CANCER RESEARCH
- Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
- (2009) Bastian Hoechst et al. HEPATOLOGY
- Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
- (2009) Jia Zhou et al. INTERNATIONAL JOURNAL OF CANCER
- Mesenchymal Stem Cell Transition to Tumor-Associated Fibroblasts Contributes to Fibrovascular Network Expansion and Tumor Progression
- (2009) Erika L. Spaeth et al. PLoS One
- Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats
- (2009) Ming-Kuei Tsai et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- PD-1 and Its Ligands in Tolerance and Immunity
- (2008) Mary E. Keir et al. Annual Review of Immunology
- Regulatory T Cells and Immune Tolerance
- (2008) Shimon Sakaguchi et al. CELL
- Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis
- (2008) Sebastián Giulianelli et al. INTERNATIONAL JOURNAL OF CANCER
- Stromal myofibroblasts are drivers of invasive cancer growth
- (2008) Olivier De Wever et al. INTERNATIONAL JOURNAL OF CANCER
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now