GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cellsex vivo

Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice

(2014) J. T. Murphy et al.   BLOOD

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C

(2013) Bruno Sangro et al.   JOURNAL OF HEPATOLOGY

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

Immunotherapy of hepatocellular carcinoma

(2012) Angela D. Pardee et al.   OncoImmunology

T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

(2012) Alexander Pedroza-Gonzalez et al.   OncoImmunology

Ipilimumab for advanced melanoma: A pharmacologic perspective

(2012) Van Anh Trinh et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Pharmacological modulation of GITRL/GITR system: therapeutic perspectives

(2011) Giuseppe Nocentini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer

(2011) Kristoffer Watten Brudvik et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells

(2011) Scott K. Pruitt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

(2011) Alexander Pedroza-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice

(2011) Jinlin Liu et al.   PLoS One

Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis

(2011) Kang-Jie Chen et al.   PLoS One

Sorafenib: Where do we go from here?

(2010) Abby B. Siegel et al.   HEPATOLOGY

Increased prevalence of regulatory T cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma

(2010) Xiaohong Shen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Low-dose Cyclophosphamide Treatment Impairs Regulatory T Cells and Unmasks AFP-specific CD4+ T-cell Responses in Patients With Advanced HCC

(2010) Tim F. Greten et al.   JOURNAL OF IMMUNOTHERAPY

Survival after Hepatic Resection for Metastatic Colorectal Cancer: Trends in Outcomes for 1,600 Patients during Two Decades at a Single Institution

(2010) Michael G. House et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

(2010) Adam D. Cohen et al.   PLoS One

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Repeat Curative Intent Liver Surgery is Safe and Effective for Recurrent Colorectal Liver Metastasis: Results from an International Multi-institutional Analysis

(2009) Mechteld C. de Jong et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study

(2009) Jedd D Wolchok et al.   LANCET ONCOLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Prognostic value of tumor-infiltrating FOXP3+ regulatory T cells in patients with hepatocellular carcinoma

(2007) A. Sasaki et al.   EJSO