Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells

(2014) C. Eken et al.   JOURNAL OF IMMUNOLOGY

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition

(2014) A. Montecalvo et al.   JOURNAL OF IMMUNOLOGY

Microvesicles: Messengers and mediators of tumor progression

(2011) Khalid Al-Nedawi et al.   CELL CYCLE

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells

(2010) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells

(2010) Hwan Myung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits

(2010) Tatjana Döring et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of Hepatic Nuclear Factor 4 Alpha

(2010) Winston Koh et al.   BMC GENOMICS

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

(2010) S. Viaud et al.   CANCER RESEARCH

DC-HIL/Glycoprotein Nmb Promotes Growth of Melanoma in Mice by Inhibiting the Activation of Tumor-Reactive T Cells

(2010) M. Tomihari et al.   CANCER RESEARCH

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn

(2010) Esther Zumaquero et al.   EXPERIMENTAL CELL RESEARCH

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis and arthritis

(2010) H Clarke Anderson et al.   LABORATORY INVESTIGATION

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

(2010) Jung Eun Park et al.   MOLECULAR & CELLULAR PROTEOMICS

Bystander suppression to unrelated allergen sensitization through intranasal administration of tolerogenic exosomes in mouse

(2010) Noela Prado et al.   MOLECULAR IMMUNOLOGY

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microparticles and their roles in inflammatory arthritides

(2010) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

Tumor Immune Evasion

(2010) C. L. Zindl et al.   SCIENCE

Polarized dendritic cells as cancer vaccines: Directing effector-type T cells to tumors

(2010) Pawel Kalinski et al.   SEMINARS IN IMMUNOLOGY

Microparticles and Exosomes in Gynecologic Neoplasias

(2010) Rienk Nieuwland et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Microparticles in Cancer

(2010) Janusz Rak   SEMINARS IN THROMBOSIS AND HEMOSTASIS

HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?

(2010) Nuria Izquierdo-Useros et al.   PLoS Pathogens

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

(2009) Bok Hong et al.   BMC GENOMICS

Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes

(2009) Sascha Keller et al.   CANCER LETTERS

Tumor Apoptotic Bodies Inhibit CTL Responses and Antitumor Immunity via Membrane-Bound Transforming Growth Factor- 1 Inducing CD8+ T-Cell Anergy and CD4+ Tr1 Cell Responses

(2009) Y. Xie et al.   CANCER RESEARCH

Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses

(2009) C.-H. Lee et al.   CLINICAL CANCER RESEARCH

CD4+CD25+CD127low/− regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

(2009) Li-Song Shen et al.   CLINICAL IMMUNOLOGY

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

(2009) Xiang-Liang Yuan et al.   CLINICAL IMMUNOLOGY

The Angiogenic Switch: Implications in the Regulation of Tumor Dormancy

(2009) L. Moserle et al.   CURRENT MOLECULAR MEDICINE

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Overcoming the Hurdles of Tumor Immunity by Targeting Regulatory Pathways in Innate and Adaptive Immune Cells

(2009) Norberto Zwirner et al.   CURRENT PHARMACEUTICAL DESIGN

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer

(2009) Bernhard Mlecnik et al.   GASTROENTEROLOGY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Herpes Simplex Virus-1 Encoded Glycoprotein B Diverts HLA-DR into the Exosome Pathway

(2009) Sebastian Temme et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Proteomic Analysis of Malignant B-Cell Derived Microparticles Reveals CD148 as a Potentially Useful Antigenic Biomarker for Mantle Cell Lymphoma Diagnosis

(2009) Laurent Miguet et al.   JOURNAL OF PROTEOME RESEARCH

Two Rabs for exosome release

(2009) Suzanne R. Pfeffer   NATURE CELL BIOLOGY

Cellular Microvesicle Pathways Can Be Targeted to Transfer Genetic Information between Non-Immune Cells

(2009) Amy M. Skinner et al.   PLoS One

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

(2009) K. Al-Nedawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Transferrin-Directed Internalization and Cycling of Transferrin Receptor 2

(2009) Juxing Chen et al.   TRAFFIC

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

(2008) N. Izquierdo-Useros et al.   BLOOD

CD44 and EpCAM: Cancer-Initiating Cell Markers

(2008) Rachid Marhaba et al.   CURRENT MOLECULAR MEDICINE

Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

(2008) Elodie Ristorcelli et al.   FASEB JOURNAL

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

More insights into the immunosuppressive potential of tumor exosomes

(2008) Veronica Huber et al.   Journal of Translational Medicine

Exosomes as a tumor immune escape mechanism: possible therapeutic implications

(2008) Thomas E Ichim et al.   Journal of Translational Medicine

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC

Role of Amphipathic Helix of a Herpesviral Protein in Membrane Deformation and T Cell Receptor Downregulation

(2008) Chan-Ki Min et al.   PLoS Pathogens

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark