Results From a First‐in‐Human Study of BNZ‐1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γc) Family of Cytokines

IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability

(2018) T. Tiffany Wang et al.   LEUKEMIA

Th9 cells and IL-9 in autoimmune disorders: Pathogenesis and therapeutic potentials

(2017) Yaxiong Deng et al.   HUMAN IMMUNOLOGY

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

(2015) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting the Binding Interface on a Shared Receptor Subunit of a Cytokine Family Enables the Inhibition of Multiple Member Cytokines with Selectable Target Spectrum

(2015) Toshie Nata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-2: Biology, Design and Application

(2015) Natalia Arenas-Ramirez et al.   TRENDS IN IMMUNOLOGY

Therapeutic activity of multiple common  -chain cytokine inhibition in acute and chronic GVHD

(2014) A.-K. Hechinger et al.   BLOOD

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer

(2014) A. Mishra et al.   CLINICAL CANCER RESEARCH

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

(2014) Luzhou Xing et al.   NATURE MEDICINE

The Biology of IL-15: Implications for Cancer Therapy and the Treatment of Autoimmune Disorders

(2013) Thomas A. Waldmann   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R 

(2011) N. Sato et al.   BLOOD

A Brief History of IL-9

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

Neutralization of IL-9 Ameliorates Experimental Autoimmune Encephalomyelitis by Decreasing the Effector T Cell Population

(2010) H. Li et al.   JOURNAL OF IMMUNOLOGY

IL-9 as a mediator of Th17-driven inflammatory disease

(2009) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE