Long telomeres and cancer risk: the price of cellular immortality

Germline mutations in Protection of Telomeres 1 in two families with Hodgkin lymphoma

(2018) Mary L. McMaster et al.   BRITISH JOURNAL OF HAEMATOLOGY

Diagnostic utility of telomere length testing in a hospital-based setting

(2018) Jonathan K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired CMV Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres

(2018) Iulia Popescu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

(2018) Andrew Mancini et al.   CANCER CELL

Telomere length, telomerase reverse transcriptase promoter mutations, and melanoma risk

(2018) Sivaramakrishna Rachakonda et al.   GENES CHROMOSOMES & CANCER

Short telomere syndromes cause a primary T cell immunodeficiency

(2018) Christa L. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

(2018) Donghyun D. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The wide spectrum of POT1 gene variants correlates with multiple cancer types

(2017) Oriol Calvete et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

(2017) James D McKay et al.   NATURE GENETICS

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases

(2017) et al.   JAMA Oncology

Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia

(2016) H. E. Speedy et al.   BLOOD

Risks of first and subsequent cancers amongTP53mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort

(2016) Phuong L. Mai et al.   CANCER

Shall we call them “telomere-mediated”? Renaming the idiopathic after the cause is found

(2016) Samantha J. Merck et al.   EUROPEAN RESPIRATORY JOURNAL

Regulating telomere length from the inside out: the replication fork model

(2016) Carol W. Greider   GENES & DEVELOPMENT

Long telomeres and cancer risk among 95 568 individuals from the general population

(2016) Line Rode et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis–emphysema

(2016) Susan E. Stanley et al.   Science Translational Medicine

Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

(2016) Daniel Chubb et al.   Nature Communications

Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder

(2015) Galina Glousker et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hepatopulmonary Syndrome Is a Frequent Cause of Dyspnea in the Short Telomere Disorders

(2015) Amany I. Gorgy et al.   CHEST

Exome Sequencing Identifies Mutant TINF2 in a Family With Pulmonary Fibrosis

(2015) Jonathan K. Alder et al.   CHEST

The short and long telomere syndromes: paired paradigms for molecular medicine

(2015) Susan E Stanley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Germline TERT promoter mutations are rare in familial melanoma

(2015) Mark Harland et al.   Familial Cancer

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

(2015) Matthew H Law et al.   NATURE GENETICS

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

(2015) Oriol Calvete et al.   Nature Communications

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1

(2014) Y. Guo et al.   BLOOD

Telomere Length in White Blood Cell DNA and Lung Cancer: A Pooled Analysis of Three Prospective Cohorts

(2014) W. J. Seow et al.   CANCER RESEARCH

Lung transplantation in telomerase mutation carriers with pulmonary fibrosis

(2014) L. L. Silhan et al.   EUROPEAN RESPIRATORY JOURNAL

Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1

(2014) Hande Kocak et al.   GENES & DEVELOPMENT

Telomerase mutations in smokers with severe emphysema

(2014) Susan E. Stanley et al.   JOURNAL OF CLINICAL INVESTIGATION

Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

(2014) Matthew N. Bainbridge et al.   JNCI-Journal of the National Cancer Institute

Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma

(2014) Lauren G. Aoude et al.   JNCI-Journal of the National Cancer Institute

POT1 loss-of-function variants predispose to familial melanoma

(2014) Carla Daniela Robles-Espinoza et al.   NATURE GENETICS

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

(2014) Jianxin Shi et al.   NATURE GENETICS

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

Telomere Phenotypes in Females with Heterozygous Mutations in the Dyskeratosis Congenita 1 (DKC1 ) Gene

(2013) Jonathan K. Alder et al.   HUMAN MUTATION

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

(2013) Pedro Castelo-Branco et al.   LANCET ONCOLOGY

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia

(2013) Helen E Speedy et al.   NATURE GENETICS

Identification of seven loci affecting mean telomere length and their association with disease

(2013) Veryan Codd et al.   NATURE GENETICS

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Longer Telomere Length in Peripheral White Blood Cells Is Associated with Risk of Lung Cancer and the rs2736100 (CLPTM1L-TERT) Polymorphism in a Prospective Cohort Study among Women in China

(2013) Qing Lan et al.   PLoS One

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Review: a meta-analysis of GWAS and age-associated diseases

(2012) William R. Jeck et al.   AGING CELL

The gastrointestinal manifestations of telomere-mediated disease

(2012) Naudia L. Jonassaint et al.   AGING CELL

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes

(2012) Geraldine Aubert et al.   PLoS Genetics

Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase

(2011) E. M. Parry et al.   BLOOD

Genetics of leukocyte telomere length and its role in atherosclerosis

(2011) Abraham Aviv   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Genome-wide association study identifies three new melanoma susceptibility loci

(2011) Jennifer H Barrett et al.   NATURE GENETICS

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

(2009) Maria Teresa Landi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging

(2009) Mary Armanios et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cancer in dyskeratosis congenita

(2009) B. P. Alter et al.   BLOOD

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

(2008) Samanthi A. Perera et al.   CARCINOGENESIS

A Prospective Study of Telomere Length and the Risk of Skin Cancer

(2008) Jiali Han et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

(2008) J. K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA