Article
Nanoscience & Nanotechnology
Ioanna Eleftheriadou, Kleoniki Giannousi, Efthymia Protonotariou, Lemonia Skoura, Minas Arsenakis, Catherine Dendrinou-Samara, Afroditi Sivropoulou
Summary: The study demonstrated that polyol-coated CuO, ZnO, and CuZn NPs can enhance the antibacterial activity of ciprofloxacin. These nanoparticles have a synergistic effect with antibiotics, inhibiting the efflux pumps of bacteria and combating multidrug resistant strains effectively.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yiwen Zhu, Shijing Wu, Yujie Sun, Xuan Zou, Liang Zheng, Shun Duan, Julin Wang, Bingran Yu, Ruifang Sui, Fu-Jian Xu
Summary: The newly designed P alpha Gal(50)-b-PGRB(20) can effectively disperse biofilms and selectively kill MDR-P. aeruginosa within biofilms by binding to Lec A in the extracellular polymeric substances and on the P. aeruginosa membrane under low phototoxicity caused by broad-spectrum aPDT. It has bactericidal activities by damaging DNA, RNA, protein, and membrane, showing potential for better corneal recovery in MDR-P. aeruginosa biofilm infected keratitis model.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Microbiology
Haley J. Appaneal, Aisling R. Caffrey, Vrishali Lopes, Emily C. Piehl, Laura A. Puzniak, Kerry L. LaPlante
Summary: We studied antibiotic co-resistance patterns in a national group of hospitalized patients with multidrug-resistant Pseudomonas aeruginosa infections. Co-resistance to commonly used antibiotic classes was common, making it difficult to select appropriate antibiotics for treatment. Poor outcomes were observed for all patients, regardless of different patterns of co-resistance. New antibiotics are needed to help treat hospitalized patients with multidrug-resistant P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Hyejin Cho, Atanu Naskar, Sohee Lee, Semi Kim, Kwang-Sun Kim
Summary: A nickel-doped zinc oxide and black phosphorus nanocomposite displayed a strong synergistic effect with polymyxin B against polymyxin-resistant E. coli, neutralizing the charge on the bacterial surface and facilitating the incorporation of polymyxin B. The combination was shown to be biocompatible and has the potential to revive polymyxins as effective antibiotics against resistant Gram-negative bacterial infections.
Article
Microbiology
Kimberly K. Kajihara, Homer Pantua, Hilda Hernandez-Barry, Meredith Hazen, Kiran Deshmukh, Nancy Chiang, Rachana Ohri, Erick R. Castellanos, Lynn Martin, Marissa L. Matsumoto, Jian Payandeh, Kelly M. Storek, Kellen Schneider, Peter A. Smith, Michael F. T. Koehler, Siao Ping Tsai, Richard Vandlen, Kelly M. Loyet, Gerald Nakamura, Thomas Pillow, Dhaya Seshasayee, Sharookh B. Kapadia, Wouter L. W. Hazenbos
Summary: This study demonstrates that an anti-P. aeruginosa AAC can locally concentrate antibiotic and kill P. aeruginosa inside phagocytes, providing additional therapeutic options for antibiotics that are moderately active or have an unfavorable pharmacokinetics or toxicity profile. This approach may provide new therapeutic options for antibiotics that are dose limited.
Article
Multidisciplinary Sciences
Remi Le Guern, Teddy Grandjean, Sarah Stabler, Marvin Bauduin, Philippe Gosset, Eric Kipnis, Rodrigue Dessein
Summary: Gut microbiome dysbiosis caused by carbapenemase-producing Enterobacterales (CPE) colonisation is associated with worsened outcomes of Pseudomonas aeruginosa lung infection in mice. The dysbiosis is characterised by decreased alveolar macrophages and conventional dendritic cells, as well as a decrease in the Muribaculaceae family and lower levels of short-chain fatty acids. Faecal microbiota transplantation restores immune responses and lung infection outcomes, indicating the involvement of CPE-induced gut dysbiosis in altering the gut-lung immune axis.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Choon Kim, Shusuke Tomoshige, Mijoon Lee, Helen I. Zgurskaya, Shahriar Mobashery
Summary: The treatment of infections by Gram-negative bacteria is challenging, and the discovery of novel antibiotics is limited. Therefore, the use of adjuvants to enhance the activities of existing antibiotics is being explored. Bulgecin A is one such adjuvant that lowers the minimal-inhibitory concentrations for beta-lactam antibiotics. It inhibits pseudomonal lytic transglycosylases, but high concentrations are needed for potentiation activity. It is not a substrate for pseudomonal efflux pumps, and the need for high concentrations is rooted in the penetration barrier into the periplasm.
Article
Infectious Diseases
Moustafa A. Tag ElDein, Aymen S. Yassin, Ossama El-Tayeb, Mona T. Kashef
Summary: The study evaluated the role of chlorhexidine in selecting resistant Pseudomonas aeruginosa mutants and their cross-resistance to antibiotics, showing that chlorhexidine can select P. aeruginosa strains with antibiotic cross-resistance. This highlights the need for special protocols for chlorhexidine use and re-evaluation of its benefits versus risks in personal-care products.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Microbiology
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu
Summary: This study reveals the response mechanism of P. aeruginosa to murepavadin and provides a promising antibiotic combination for the treatment of P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu
Summary: This study reveals the response mechanism of Pseudomonas aeruginosa to murepavadin and provides a promising antibiotic combination for the treatment of P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Shashikant Srivastava, Tawanda Gumbo, Tania Thomas
Summary: Cefazolin-avibactam combination has shown efficacy against MDR-TB and drug susceptible TB strains in children through PK/PD principles. The optimal dosing strategy was determined based on age-specific CFR and Mtb susceptibility breakpoint, highlighting the potential of repurposing cefazolin for pediatric TB treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Ana Polo, Ari Lemos, Camila Martins da Mata, Veronica Oliveira, Ana Pontes, Daniel Pontes, Guilherme Tavares, Rodrigo Fabri, Ana Carolina Apolonio
Summary: This study evaluated the effect of a new Fe-cyclam complex on pathogenic bacterial species, including multidrug-resistant clinical specimens. The complex showed broad bacterial activity, mainly against Cutibacterium acnes, S. aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii. The tested compound proved to be a promising agent against resistant bacterial infections.
FUTURE MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
William Ndugire, Dang Truong, N. G. Hasitha Raviranga, Jingzhe Lao, Olof Ramstrom, Mingdi Yan
Summary: The addition of thiourea (TU) enhances the broad-spectrum antimicrobial activity of D-maltose-capped gold nanoclusters (AuNC-Mal). AuNC-Mal/TU exhibits effective inhibition against multidrug-resistant Pseudomonas aeruginosa with low cytotoxicity. The antimicrobial activity is attributed to the generation of [Au(TU)(2)](+) and smaller AuNCs, increased accumulation of Au in bacteria, and inhibition of thioredoxin reductase.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Infectious Diseases
Paulina Paprocka, Bonita Durnas, Angelika Mankowska, Karol Sklodowski, Grzegorz Krol, Magdalena Zakrzewska, Michal Czarnowski, Patrycja Kot, Kamila Fortunka, Stanislaw Gozdz, Paul B. Savage, Robert Bucki
Summary: The study demonstrates that ceragenins exhibit high activity against clinical strains of Pseudomonas aeruginosa with low potential for resistance development. When used in conjunction with poloxamer 407, ceragenins show controlled toxicity, supporting their potential development as new antibiotics to combat infections caused by antibiotic resistant strains of Pseudomonas aeruginosa.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Chunyang Shi, Yangmin Ma, Lei Tian, Jingyi Li, Guaiping Qiao, Chang Liu, Wenqiang Cao, Chengyuan Liang
Summary: In this study, verbascoside demonstrated excellent antibacterial activity and synergistic effects when combined with cell wall synthesis-inhibiting antibiotics, making it a potential adjuvant to enhance the effectiveness of antibiotics. Mechanistically, verbascoside exhibited antimicrobial activity through various mechanisms and showed potential as a novel antimicrobial additive in the food industry.
Article
Biochemistry & Molecular Biology
Temilolu Idowu, Pranati Samadder, Gilbert Arthur, Frank Schweizer
CHEMISTRY AND PHYSICS OF LIPIDS
(2016)
Article
Biochemistry & Molecular Biology
Makanjuola Ogunsina, Pranati Samadder, Temilolu Idowu, Gilbert Arthur, Frank Schweizer
Article
Chemistry, Medicinal
Temilolu Idowu, Pranati Samadder, Gilbert Arthur, Frank Schweizer
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Makanjuola Ogunsina, Pranati Samadder, Temilolu Idowu, Gilbert Arthur, Frank Schweizer
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Yinfeng Lyu, Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Temilolu Idowu, Ronald Domalaon, George G. Zhanel, Anshan Shan, Frank Schweizer
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Review
Microbiology
Ronald Domalaon, Temilolu Idowu, George G. Zhanel, Frank Schweizer
CLINICAL MICROBIOLOGY REVIEWS
(2018)
Review
Pharmacology & Pharmacy
George G. Zhanel, Alyssa R. Golden, Sheryl Zelenitsky, Karyn Wiebe, Courtney K. Lawrence, Heather J. Adam, Temilolu Idowu, Ronald Domalaon, Frank Schweizer, Michael A. Zhanel, Philippe R. S. Lagace-Wiens, Andrew J. Walkty, Ayman Noreddin, Joseph P. Lynch, James A. Karlowsky
Article
Infectious Diseases
Temilolu Idowu, Derek Ammeter, Gilbert Arthur, George G. Zhanel, Frank Schweizer
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Chemistry, Medicinal
Temilolu Idowu, Gilbert Arthur, George G. Zhanel, Frank Schweizer
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Xuan Yang, Derek Ammeter, Temilolu Idowu, Ronald Domalaon, Marc Brizuela, Oreofe Okunnu, Liting Bi, Yanelis Acebo Guerrero, George G. Zhanel, Ayush Kumar, Frank Schweizer
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Temilolu Idowu, Derek Ammeter, Heather Rossong, George G. Zhanel, Frank Schweizer
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Microbiology
Temilolu Idowu, George G. Zhanel, Frank Schweizer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Biochemistry & Molecular Biology
Makanjuola Ogunsina, Pranati Samadder, Temilolu Idowu, Mark Nachtigal, Frank Schweizer, Gilbert Arthur
Review
Infectious Diseases
Temilolu Idowu, Frank Schweizer