Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Qiongjie Zhou, Xingzhong Zhao, Jinghui Xu, Yu Xiong, Jon F. R. Barrett, Xing-Ming Zhao, Xiaotian Li
Summary: This retrospective study aimed to describe the frequency of preeclampsia and aspirin use in real-world practice among women with twin pregnancies. The results showed that the use of low-dose aspirin was associated with a higher incidence of preeclampsia, possibly due to poor compliance with the medication. Further randomized controlled trials or prospective cohort studies are needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Piotr Tousty, Magda Fraszczyk-Tousty, Sylwia Dzidek, Hanna Jasiak-Jozwik, Kaja Michalczyk, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Andrzej Torbe, Sebastian Kwiatkowski
Summary: Preeclampsia is a complex disorder of pregnancy with significant fetal and maternal consequences, and aspirin is recommended for high-risk women to reduce the risk. This review compared 14 guidelines and found variations in recommended dose, screening method, and timing for starting aspirin. Many societies now recommend higher doses (>75 mg) of aspirin, with most suggesting initiation before 16 weeks' gestation. The introduction of risk assessment models, such as the one proposed by the Fetal Medicine Foundation, has led to a shift in recommendations towards identifying high-risk populations and implementing aspirin prophylaxis, resulting in reduced morbidity for mothers and infants.
Article
Obstetrics & Gynecology
Li Lin, Jing Huai, Boya Li, Yuchun Zhu, Juan Juan, Meihua Zhang, Shihong Cui, Xianlan Zhao, Yuyan Ma, Yangyu Zhao, Yang Mi, Hongjuan Ding, Dunjin Chen, Weishe Zhang, Hongbo Qi, Xiaotian Li, Guanlin Li, Jiahui Chen, Huijing Zhang, Mengting Yu, Xiaotong Sun, Huixia Yang
Summary: The use of 100 mg aspirin for prevention of preeclampsia in high-risk pregnant women in China did not show significant efficacy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Eleanor Christenson, Molly J. Stout, Dominique Williams, Amanda K. Verma, Victor G. Davila-Roman, Kathryn J. Lindley
Summary: This study aimed to identify clinical risk factors and serum biomarkers associated with postpartum hypertension (PP-HTN) in preeclampsia. The results showed that one-third of preeclamptic women developed PP-HTN, with more severe preeclampsia features and higher re-hospitalization rates. Low-dose aspirin (ASA) use during pregnancy was associated with a significantly lower incidence of PP-HTN, reduced levels of antiangiogenic factors, and lower 6-week re-hospitalization rates.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Endocrinology & Metabolism
Guanlin Li, Wei Wei, Lingge Suo, Chun Zhang, Haiyan Yu, Hui Liu, Qing Guo, Xiumei Zhen, Yang Yu
Summary: The study demonstrated that aspirin treatment can effectively improve renal failure and pathological changes induced by preeclampsia, attenuating tubular injury and reducing kidney inflammation. It also suppresses renal cell apoptosis and oxidative stress. The mechanism involves inhibition of the WNT5A/NF-kappa B signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
C. Stern, K. Mayer-Pickel, E. -C. Weiss, K. Kutllovci-Hasani, M. Nanda, K. Eberhard, M. Cervar-Zivkovic, F. Prueller
Summary: Preeclampsia remains a life-threatening pregnancy complication with severe morbidity and mortality. Low-dose Aspirin is globally recommended to prevent preeclampsia in high-risk pregnancies, but there are still questions around optimal dosing and effectiveness. This study found that around one third of women did not have sufficient platelet inhibition even with a daily dosage of 150 mg Aspirin, suggesting a need for further personalized research to maximize preventive benefits for both mother and child.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Ying Ye, Li Wen, Xiyao Liu, Lan Wang, Yamin Liu, Richard Saffery, Mark D. Kilby, Chao Tong, Hongbo Qi, Philip Baker
Summary: The study found that the use of low-dose aspirin in twin pregnancies significantly reduced the risk of preeclampsia and preterm birth, with possible benefits in lowering the rate of small for gestational age babies. Furthermore, the use of low-dose aspirin did not increase the risk of postpartum hemorrhage.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Veronica M. Gonzalez-Brown, Marwan Ma'ayeh, Douglas A. Kniss, Michael Cackovic, Mark B. Landon, Kara M. Rood
Summary: Daily administration of LDA increases 15-epi-LXA4 levels in high-risk pregnancies for PE, but patients with PE have lower 15-epi-LXA4 levels compared to those without PE.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2021)
Review
Obstetrics & Gynecology
Eleanor M. F. Richards, Veronica Giorgione, Oliver Stevens, Basky Thilaganathan
Summary: This systematic review and meta-analysis aimed to investigate the potential benefits of low-dose aspirin use during pregnancy in women with chronic hypertension. The analysis found that low-dose aspirin did not significantly reduce the odds of superimposed preeclampsia or poor perinatal outcomes. However, it did show a significant reduction in preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ka Cheuk Yip, Ziyin Luo, Xiaman Huang, Weijen Lee, Layla Li, Chenyang Dai, Weiyu Zeng, Tsz Ngai Mok, Qiyu He, Ruiman Li
Summary: The meta-analysis suggests that high-risk pregnant women can prevent preeclampsia or preterm delivery by taking low-dose aspirin; the most efficient period is <= 16 weeks of gestation, and the best dose is >= 100 mg.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Public, Environmental & Occupational Health
Jacqueline E. Rudolph, Kwangho Kim, Edward H. Kennedy, Ashley I. Naimi
Summary: This study aims to assess the incremental effects of time-varying exposure, using data from an experiment on the impact of aspirin on pregnancy outcomes. The results suggest that increasing women's probability of taking aspirin has little impact on pregnancy rates.
Article
Obstetrics & Gynecology
Si Sun, HongYang Qian, Congcong Li, Qiaohong Wang, Aimin Zhao
Summary: This study retrospectively investigated the safety of low dose aspirin (LDA) during pregnancy. The results showed that the use of aspirin did not increase the risk of fetal congenital anomalies. Additionally, a previous history of fetal abnormalities was found to be an independent risk factor for congenital anomalies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Wen-Yue Chen, Su-Fang Sun
Summary: This systematic review and meta-analysis evaluated the clinical effectiveness of low-dose aspirin combined with calcium supplements for the prevention of preeclampsia. The results showed that compared with the control group, the experimental group had lower incidence rates of preeclampsia with gestational hypertension, preeclampsia, gestational hypertension, preterm birth, postpartum hemorrhage, and fetal growth restriction.
Article
Oncology
Li Wang, Zaoxiu Hu, Ceshi Chen, Ting Chen, Zhihong Yao, Wenhui Li, Zuozhang Yang
Summary: This study investigated the effect of low-dose aspirin on breast cancer radiotherapy through the mechanism of exosomes and natural killer cells. The results showed that low-dose aspirin could inhibit the release of breast cancer cell exosomes and alleviate their inhibitory effect on natural killer cell proliferation. In addition, aspirin could enhance the radiotherapy sensitivity of breast cancer cells and inhibit tumor growth.
Article
Biology
Jay S. Mishra, Chellakkan S. Blesson, Sathish Kumar
Article
Biochemistry & Molecular Biology
Olivia Ruhen, Bob Mirzai, Michael E. Clark, Bella Nguyen, Carlos Salomon, Wendy Erber, Katie Meehan
Summary: Increasing recognition of ctDNA as a non-invasive alternative for molecular characterisation and disease monitoring. Limited research on the relationship between EV DNA and ctDNA, with ctDNA showing greater sensitivity in monitoring breast cancer progression.
Article
Biochemistry & Molecular Biology
Pingping Han, Peter Mark Bartold, Carlos Salomon, Saso Ivanovski
Summary: The study compared salivary sEVs from periodontitis patients, healthy controls, and gingivitis patients, finding that global 5mC hypermethylation in salivary sEVs can serve as a potential biomarker with high sensitivity and specificity for distinguishing periodontitis patients. Periodontitis sEVs showed significantly increased levels of LPS+ OMVs, global 5mC methylation, and periodontal pathogens, which were more pronounced in sEVs than whole saliva.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Ruolin Song, Jay S. Mishra, Sri Vidya Dangudubiyyam, Kathleen M. Antony, Tracy L. Baker, Jyoti J. Watters, Sathish Kumar
Summary: This study found that gestational intermittent hypoxia exposure leads to different effects on weight and growth in offspring, but does not impact cardiac functions significantly. In adulthood, male offspring showed an increase in blood pressure and alterations in vascular mechanisms, while female offspring remained relatively stable. There are distinct differences in blood pressure, endothelial function, and sex hormone levels between male and female offspring exposed to gestational intermittent hypoxia.
REPRODUCTIVE SCIENCES
(2022)
Article
Oncology
Mona Alharbi, Andrew Lai, Shayna Sharma, Priyakshi Kalita-de Croft, Nihar Godbole, America Campos, Dominic Guanzon, Alexis Salas-Burgos, Flavio Carrion, Felipe A. Zuniga, Lewis Perrin, Yaowu He, Tanja Pejovic, Carmen Winters, Terry Morgan, John D. Hooper, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most lethal cancers worldwide affecting women, with non-specific early symptoms. sEVs produced under low oxygen tension can induce a metabolic switch in ovarian cancer cells, promoting resistance to carboplatin. The presence of glycolysis pathway proteins in sEVs is closely associated with ovarian cancer recurrence.
Review
Oncology
America Campos, Shayna Sharma, Andreas Obermair, Carlos Salomon
Summary: The article discusses the association between miRNAs within extracellular vesicles (EVs) and chemotherapy resistance, identifying certain miRNAs in various cancers linked to chemoresistance. Studies suggest that miR-21, miR-222, and miR-155 have roles in response to chemotherapy in different types of tumors.
Article
Oncology
Narshone Soda, Zennia Jean Gonzaga, Amandeep Singh Pannu, Navid Kashaninejad, Richard Kline, Carlos Salomon, Nam-Trung Nguyen, Prashant Sonar, Bernd H. A. Rehm, Muhammad J. A. Shiddiky
Summary: Genomic profiling of cancer-derived materials in circulation is an important approach for tumor genotyping, enabling enhanced cancer screening, early diagnosis, and therapy response evaluation. The development of a multifaceted technology platform based on bioengineered polymer nanobeads allows for efficient capture and electrochemical detection of DNA methylation in ovarian cancer patient samples. This versatile diagnostic platform can be used for detecting various disease biomarkers and multiple disease diagnoses.
Review
Cell Biology
Priyakshi Kalita-de Croft, Shayna Sharma, Nihar Godbole, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most diagnosed gynecological cancers in women, often diagnosed at an advanced stage due to the lack of effective early screening. Extracellular vesicles play a crucial role in the tumor microenvironment of ovarian cancer, with potential applications in diagnosis, delivery of therapeutic agents, and disease monitoring.
Article
Oncology
Kekoolani S. Visan, Richard J. Lobb, Shu Wen Wen, Justin Bedo, Luize G. Lima, Sophie Krumeich, Carlos Palma, Kaltin Ferguson, Ben Green, Colleen Niland, Nicole Cloonan, Peter T. Simpson, Amy E. McCart Reed, Sarah J. Everitt, Michael P. MacManus, Gunter Hartel, Carlos Salomon, Sunil R. Lakhani, David Fielding, Andreas Moeller
Summary: Lung cancer is a leading cause of cancer-related death worldwide and has low survival rates due to lack of early detection. A study on a lung cancer biomarker based on a simple blood test shows promising advantages for diagnostic assessment. The study identifies a specific micro-RNA, miR-3182, as a potential biomarker for lung cancer diagnosis that can be detected in the blood.
Article
Biochemistry & Molecular Biology
Carlos Palma, H. David McIntyre, Carlos Salomon
Summary: Research on extracellular vesicles (EVs) has provided insights into physiological and pathophysiological conditions, particularly during pregnancy. Gestational diabetes mellitus (GDM) is a common and influential complication that affects the miRNAs and proteins within EVs, leading to metabolic changes.
Article
Biochemistry & Molecular Biology
Olivia Ruhen, Xinyu Qu, M. Fairuz B. Jamaluddin, Carlos Salomon, Aesha Gandhi, Michael Millward, Brett Nixon, Matthew D. Dun, Katie Meehan
Summary: This study aimed to quantitatively profile the proteomes of EVs isolated from blood samples of metastatic breast cancer patients to identify proteins associated with treatment response.
Article
Chemistry, Analytical
Kimberley Clack, Narshone Soda, Surasak Kasetsirikul, Richard Kline, Carlos Salomon, Muhammad J. A. Shiddiky
Summary: In this study, we developed a novel and rapid method to detect HOTAIR sequences. The method showed high specificity and sensitivity in clinical samples, making it a potential tool for ovarian cancer diagnosis.
Article
Reproductive Biology
Sri Vidya Dangudubiyyam, Jay S. Mishra, Sathish Kumar
Summary: This study aimed to investigate the endocrine-disrupting effects of PFOS on placental function in pregnant rats. Results showed that PFOS dose-dependently decreased fetal and placental weight, specifically in the labyrinth layer. It also caused alterations in hormone levels and gene expression related to steroid hormone biosynthesis and metabolism in the placenta.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Reproductive Biology
Ruolin Song, Pankaj Yadav, Sri Vidya Dangudubiyyam, Alissa Hofmann, Jay S. Mishra, Sathish Kumar
Summary: This study found that obstructive sleep apnea during pregnancy is a risk factor for gestational hypertension, and the mechanism behind this is through perturbed endothelin-1 signaling. Pregnant rats exposed to intermittent hypoxia demonstrated elevated blood pressure and impaired vascular function.
BIOLOGY OF REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Sri Vidya Dangudubiyyam, Bradley Bosse, Pankaj Yadav, Ruolin Song, Alissa Hofmann, Jay S. Mishra, Sathish Kumar
Summary: This study found that AT2R activation can improve maternal vascular dysfunction and blood flow caused by PFOS exposure, restoring normal fetal growth. This provides important preclinical evidence for the prevention or treatment of adverse maternal and fetal outcomes caused by PFOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)