Article
Obstetrics & Gynecology
Luigi Della Corte, Giada Lavitola, Giuseppe Bifulco
Summary: This retrospective cohort study aimed to assess the impact of preoperative endocervicoscopy on obstetric outcomes and complications in women undergoing LEEP for CIN2+. The results showed that endocervicoscopy reduced the amount of tissue excised at LEEP and had a significant effect on the involvement of lesion margins and cervical measurements. There was no significant difference in the number of pregnancies after LEEP, but the incidence of threatened preterm labor and threatened miscarriage was significantly lower in the endocervicoscopy group.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Oncology
Alfonso Lopez de Sa, Alejandro Pascual, Javier Garcia Santos, Ramiro Mendez, Monica Bellon, Mar Ramirez, Fatima Matute, Cristina Del Arco, Aranzazu Manzano, Pluvio Coronado, Antonio Casado, Gloria Marquina
Summary: Inflammatory myofibroblastic tumour is a rare neoplasm with variable behavior, rarely found in the female genital tract. Surgical resection is the main treatment option, while chemotherapy and radiotherapy are reserved for advanced or metastatic cases. Tyrosine kinase inhibitor crizotinib has shown promising results, especially in tumors with ALK mutation.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Shi-Wen Zhang, Rong-Zhen Luo, Xiao-Ying Sun, Xia Yang, Hai-Xia Yang, Si-Ping Xiong, Li-Li Liu
Summary: The study found that the co-expression of SOX2 with HR-HPV RISH in SCNEC may be an independent factor predicting poorer overall and disease-free survival outcomes. SOX2 and HR-HPV RISH expression, either separately or in combination, were associated with poor prognosis in SCNEC patients.
Article
Virology
John Doorbar, Ke Zheng, Ademola Aiyenuro, Wen Yin, Caroline M. Walker, Yuwen Chen, Nagayasu Egawa, Heather M. Griffin
Summary: Human papillomaviruses establish infection reservoirs in the epithelial basal layer by limiting gene expression to evade immune detection and modulating epithelial homeostasis pathways. Different types of papillomaviruses have distinct mechanisms to restrict lesion expansion, with high-risk strains capable of inducing tumor formation in immunocompetent hosts.
CURRENT OPINION IN VIROLOGY
(2021)
Review
Obstetrics & Gynecology
Tingting Xie, Xiya Xu, Yi Yang, Cangui Wu, Xiaohan Liu, Lili Zhou, Yali Song
Summary: Adenomyosis is a benign disease with malignant behavior that affects the quality of life of many women of reproductive age. Currently, there is no effective treatment and the pathogenesis is unclear. Recent research suggests that the uterus junctional zone may play an important role in the development of adenomyosis, providing new insights for future treatment strategies.
REPRODUCTIVE SCIENCES
(2022)
Article
Physics, Multidisciplinary
Guo-Sheng Lin, Shih-Cheng Tu, Chong-Ian Mok, Tsan-Hsueh Huang, Chi-Hau Chen, Lin-Hung Wei, Kung-Bin Sung
Summary: This study used two-layer forward Monte Carlo models to predict diffuse reflectance and fluorescence intensities of cervical mucosa. The models showed improved accuracy in estimating tissue properties and detecting precancerous changes compared to conventional models. It suggests the potential of fluorescence spectroscopy for detecting precancers in the cervix.
FRONTIERS IN PHYSICS
(2022)
Article
Medicine, Research & Experimental
Martha Cecilia Ramos Ramirez, Diana Callejas de Valero, Gisnella Maria Cedeno Cajas, Adriana Monserrath Monge Moreno, Maria Fernanda Tinajero Vasconez
Summary: The study found a high prevalence of high-risk HPV genotypes in the Ecuadorian population, but most were associated with low-grade cervical lesions. Only a small percentage of patients infected with HPV 16 showed a link to high-grade lesions, and there was no association between viral genotype and patient age.
INVESTIGACION CLINICA
(2021)
Article
Biotechnology & Applied Microbiology
Qianqian Zhang, Liju Zong, Hui Zhang, Wei Xie, Fan Yang, Wenwen Sun, Baoxia Cui, Youzhong Zhang
Summary: This study investigated factors related to the absence of lesions in cervical conization specimens in patients diagnosed with CIN and found an association between B7-H4 expression, T cell populations, and interferon-gamma production with the presence of lesions. The study suggested that patients negative for B7-H4 expression on biopsy should undergo close follow-up and reevaluation before undergoing cervical conization, especially for those diagnosed with CIN2.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Jobran M. Moshi, Monique Ummelen, Jos L. Broers, Frank Smedts, Koen K. Van de Vijver, Jack P. M. Cleutjens, Rogier J. N. T. M. Litjens, Frans C. S. Ramaekers, Anton H. N. Hopman
Summary: SOX2 expression is increased in high-grade cervical intraepithelial neoplasia and cervical squamous cell carcinoma compared to normal cervical epithelium. The expression pattern of SOX2 changes during the progression of CIN, with increased expression in the intermediate/superficial compartment. A specific expression pattern is found in CIN2 and CIN3, which is significantly associated with CIN3 and contains HPV-positive cells in the basal/parabasal compartment. This study provides new insights into the pathogenesis and dynamics of premalignant cervical lesions and the target cells for HPV infection.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Biology
Chiara Paternostro, Elmar A. Joura, Christina Ranftl, Eva-Maria Langthaler, Robin Ristl, Tim Dorritke, Sophie Pils
Summary: The aim of this study was to evaluate the endocervical margin status in relation to transformation zone and high-risk HPV subtype in different sizes of cone specimens. The study found that performing an excision length greater than 10 mm did not provide additional oncological benefits for certain patients. The decision regarding excision length should consider both oncological safety and the risk of adverse pregnancy events. HPV 18 positivity was associated with a higher rate of positive endocervical margins regardless of the transformation zone.
Editorial Material
Medicine, General & Internal
Anne-Sophie Wegscheider, Nikolas Tauber, Kirsten Graubner, Gudrun Ziegeler, Michael Behr, Christoph Lindner, Axel Niendorf
Summary: This article describes a rare case of high-grade squamous intraepithelial lesion of the right fallopian tube in a 51-year-old woman who underwent abdominal hysterectomy. The presence of this lesion raises questions about the possibility of a virus-associated field effect and emphasizes the importance of examining the fallopian tube in routine settings.
Article
Obstetrics & Gynecology
J. F. Robles Diaz, F. A. Salvador Reyes
Summary: Adenoid cystic carcinoma is a rare pathology with high risk of recurrence, currently lacking standard management, but reported to be radiosensitive.
CLINICA E INVESTIGACION EN GINECOLOGIA Y OBSTETRICIA
(2021)
Article
Pathology
Elizabeth Arslanian, Kamaljeet Singh, Katrine Hansen, M. Ruhul Quddus
Summary: This study describes benign stratified intraepithelial mucinous proliferation of the cervix (BSIMP), which morphologically overlaps with SMILE and is present in the majority of SMILE cases. The multilayered form poses a diagnostic challenge when mitotically active. Its presence should prompt further scrutiny to rule out associated dysplasia due to the often-coexistent high-grade squamous intraepithelial lesion (HSIL).
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Obstetrics & Gynecology
Priyanka Meena, Amita Suneja, Richa Aggarwal, Neelam B. Vaid, Kiran Mishra
Summary: Endocervicoscopy is an effective and safe technique for visualizing the T3 transformation zone in colposcopy. Observing the squamocolumnar junction through endocervicoscopy is significant in predicting premalignant and malignant lesions, with high positive and negative predictive values.
JOURNAL OF MID-LIFE HEALTH
(2021)
Review
Pathology
Ahmed Alrajjal, Vaishali Pansare, Moumita Saha Roy Choudhury, Mir Yousufuddin Ali Khan, Vinod B. Shidham
Summary: Cervical cancer has high incidence and mortality rates among women in the United States. Cervical Pap test is the best screening method, and The Bethesda System is recommended for reporting. Different cytomorphologic features distinguish various squamous categories, aiding in identification through algorithmic approach and common patterns.
Article
Pathology
Oliver Hommerding, Yves Allory, Pedram Argani, Tarek A. Bismar, Lukas Bubendorf, Sofia Canete-Portillo, Alcides Chaux, Ying-Bei Chen, Liang Cheng, Antonio L. Cubilla, Lars Egevad, Anthony J. Gill, David J. Grignon, Arndt Hartmann, Ondrej Hes, Muhammad T. Idrees, Chia-Sui Kao, Margaret A. Knowles, Leendert H. J. Looijenge, Tamara L. N. Lota, Colin C. Pritchard, Mark A. Rubin, Scott A. Tom Fins, Theodorus H. Van der Kwast, Elsa F. Velazquez, Joshua Warrick, Sean R. Williamson, Glen Kristiansen
Summary: This article summarizes the consensus conference held by the International Society of Urogenital Pathology in March 2019 on molecular diagnostics of genitourinary tumors. Five working groups presented the research results and background information, and developed diagnostic action recommendations, with 66% agreement among conference participants defined as consensus.
Review
Oncology
Caroline C. C. Hulsker, Issam el Mansori, Marta Fiocco, Jozsef Zsiros, Marc H. W. Wijnen, Leendert H. J. Looijenga, Annelies M. C. Mavinkurve-Groothuis, Alida F. W. van der Steeg
Summary: Germ cell tumours are a heterogeneous group of neoplasms occurring predominantly in midline locations from birth to late adulthood. Despite the heterogeneity, subpopulations with inferior survival outcomes have been identified, potentially benefiting from future research and more individualised treatment strategies. This systematic review highlights the impact of tumour location on stage at presentation, treatment modalities, and survival data, emphasizing the importance of tailored approaches to improve outcomes.
Review
Urology & Nephrology
Ricardo Leao, Maarten Albersen, Leendert H. J. Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J. Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J. Hamilton, Klaus-Peter Dieckmann
Summary: Circulating microRNA levels, especially miR-371a-3p, show promise for clinical use in testicular germ cell tumors, with high sensitivity and specificity in various clinical scenarios, potentially aiding in clinical decision-making.
Article
Biochemistry & Molecular Biology
Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga
Summary: Germ cell tumors (GCTs) have varying responses to platinum-based chemotherapy depending on their anatomical origin, with mediastinal GCTs showing resistance compared to testicular GCTs. TP53 mutations may play a role in causing cisplatin resistance in mediastinal GCTs, suggesting a potential target for treatment. The study provides insights into the underlying mechanisms of TP53 mutant and mediastinal GCTs for alternative treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Monika Bialecka, Joaquin Montilla-Rojo, Bernard A. J. Roelen, Ad J. Gillis, Leendert H. J. Looijenga, Daniela. C. F. Salvatori
Summary: This study compared tumour development in humanized immune system (HIS) mice and immunocompromised mice (NSG) after injection of cell lines, revealing that the HIS mouse model is comparable to, but not more sensitive than, the NSG immunodeficient model for studying the malignancy of stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Dennis M. Timmerman, Thomas F. Eleveld, Sruthi Sriram, Lambert C. J. Dorssers, Ad J. M. Gillis, Silvia Schmidtova, Katarina Kalavska, Harmen J. G. van de Werken, Christoph Oing, Friedemann Honecker, Michal Mego, Leendert H. J. Looijenga
Summary: In male type II germ cell tumors (GCTs), cisplatin resistance and poor clinical outcome are strongly associated with the status of 3p25.3. Genomic profiling based on this gene can help improve risk stratification in male patients with type II GCT.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Maria J. De Herdt, Berdine van der Steen, Robert J. Baatenburg de Jong, Leendert H. J. Looijenga, Senada Koljenovic, Jose A. Hardillo
Summary: Head and neck cancer, particularly oral cancer, is a common type of cancer with a low survival rate. Targeted therapies that focus on the MET protein have gained attention, but the lack of companion diagnostics complicates treatment. Shedding of the ectodomain of MET and its association with poor prognosis in oral squamous cell carcinoma highlight the importance of investigating MET-EC- and incorporating it into companion diagnostics.
Article
Cell Biology
Jobran M. Moshi, Monique Ummelen, Jos L. Broers, Frank Smedts, Koen K. Van de Vijver, Jack P. M. Cleutjens, Rogier J. N. T. M. Litjens, Frans C. S. Ramaekers, Anton H. N. Hopman
Summary: SOX2 expression is increased in high-grade cervical intraepithelial neoplasia and cervical squamous cell carcinoma compared to normal cervical epithelium. The expression pattern of SOX2 changes during the progression of CIN, with increased expression in the intermediate/superficial compartment. A specific expression pattern is found in CIN2 and CIN3, which is significantly associated with CIN3 and contains HPV-positive cells in the basal/parabasal compartment. This study provides new insights into the pathogenesis and dynamics of premalignant cervical lesions and the target cells for HPV infection.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Cezanne D. Kooij, Annelies M. C. Mavinkurve-Groothuis, Idske C. L. Kremer Hovinga, Leendert H. J. Looijenga, Tuula Rinne, Jacques C. Giltay, Laetitia M. O. de Kort, Aart J. Klijn, Ronald R. de Krijger, Annemarie A. Verrijn Stuart
Summary: This study reports the development of malignant testicular germ cell tumors in two young adult males with familial male-limited precocious puberty (FMPP) due to LHCGR pathogenic variants. The study also investigates the potential link between FMPP and testicular tumors. The results suggest that FMPP might increase the risk of developing testicular GCTs in early adulthood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Kaylee M. M. Keller, Thomas F. F. Eleveld, Linda Schild, Kim van den Handel, Marlinde van den Boogaard, Vicky Amo-Addae, Selma Eising, Kimberley Ober, Bianca Koopmans, Leendert Looijenga, Godelieve A. M. Tytgat, Bauke Ylstra, Jan J. J. Molenaar, M. Emmy M. Dolman, Sander R. R. van Hooff
Summary: Neuroblastoma, a common solid tumor in children, remains challenging to treat with low survival rates, particularly in high-risk patients. Chromosome 11q loss and MYCN amplification are genetic subsets associated with poor outcomes, and checkpoint kinase 1 (CHK1) is identified as a potential therapeutic target for 11q deleted neuroblastoma. Additionally, MYCN amplification may serve as a biomarker for CHK1 inhibition, independent of 11q loss.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maria E. Camacho-Moll, Leendert H. J. Looijenga, Roland Donat, Chitranjan J. Shukla, Anne Jorgensen, Rod T. Mitchell
Summary: Testicular germ cell cancer (TGCC) is a common type of cancer in men, originating from immature germ cells. Sertoli cells, which are important for the survival and development of these germ cells, are also immature in TGCC. This study investigated the expression of desmin and cytokeratin proteins in Sertoli cells and found that desmin is not useful for detecting immature Sertoli cells, while cytokeratin may be useful for diagnosing impaired testicular development and pre-invasive TGCC.
Article
Endocrinology & Metabolism
Sabine E. Hannema, Katja P. Wolffenbuttel, Yolande van Bever, Hennie T. Bruggenwirth, Sjoerd A. A. van den Berg, Remko Hersmus, J. Wolter Oosterhuis, Leendert H. J. Looijenga
Summary: Individuals with 45,X/46,XY or 46,XY gonadal dysgenesis have an increased risk of germ cell malignancies. This study aimed to determine if undetectable preoperative serum anti-Mullerian hormone (AMH) and inhibin B can predict the absence of germ cells or (pre)malignant conditions. The results suggest that undetectable AMH and inhibin B cannot reliably predict the absence of germ cells in individuals with gonadal dysgenesis. Rating: 8/10.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joaquin Montilla-Rojo, Monika Bialecka, Kimberley E. E. Wever, Christine L. L. Mummery, Leendert H. J. Looijenga, Bernard A. J. Roelen, Daniela C. F. Salvatori
Summary: Pluripotency is crucial for assessing stem cells, but there is a lack of standardization in the teratoma assay and ethical concerns about animal use. In vitro alternatives have been developed, but their use and malignancy testing remain limited. The teratoma assay is still preferred for safety assessment, highlighting the need for an in vitro assay for testing stem cell malignancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Summary: This study provides multi-omics profiling of malignant germ cell tumors (GCTs) across different age groups, showing that the WNT signaling pathway is activated in GCTs and is associated with poor clinical outcomes.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Francis S. P. L. Wens, Caroline C. C. Hulsker, Marta Fiocco, Jozsef Zsiros, Stephanie E. Smetsers, Ronald R. de Krijger, Alida F. W. van der Steeg, Ronald P. Zweemer, Inge O. Baas, Eva Maria Roes, Leendert H. J. Looijenga, Cornelis G. Gerestein, Annelies M. C. Mavinkurve-Groothuis
Summary: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive ovarian cancer with a poor prognosis. More research and international collaboration are needed to improve the treatment and outcome for SCCOHT patients. Mutations in the SMARCA4 gene play a crucial role in accurate diagnosis and may lead to new treatment options.
