Article
Multidisciplinary Sciences
Shuangqiu Du, Linlin Sun, Yun Wang, Wenhao Zhu, Jialin Gao, Wenjun Pei, Yao Zhang
Summary: This study evaluated the relationship between ADAM12 gene expression and hepatocellular carcinoma (HCC) using The Cancer Genome Atlas (TCGA) datasets. The results showed that ADAM12 gene was significantly and highly expressed in liver cancer tissue and correlated with clinical features and prognosis of patients with liver cancer. Pathway analysis and in vitro experiments revealed the potential mechanisms and effects of ADAM12 on HCC development.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga
Summary: Germ cell tumors (GCTs) have varying responses to platinum-based chemotherapy depending on their anatomical origin, with mediastinal GCTs showing resistance compared to testicular GCTs. TP53 mutations may play a role in causing cisplatin resistance in mediastinal GCTs, suggesting a potential target for treatment. The study provides insights into the underlying mechanisms of TP53 mutant and mediastinal GCTs for alternative treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lisa M. Ebert, Kate Vandyke, M. Zahied Johan, Mark DeNichilo, Lih Y. Tan, Kay K. Myo Min, Benjamin M. Weimann, Brenton W. Ebert, Stuart M. Pitson, Andrew C. W. Zannettino, Craig T. Wallington-Beddoe, Claudine S. Bonder
Summary: Desmoglein-2 (DSG2) is found to be overexpressed in approximately 20% of bone marrow biopsies from newly diagnosed multiple myeloma patients, and it is strongly predictive of poor clinical outcome, independent of genetic subtype or routinely measured biomarkers of MM activity. This cell surface protein may serve as a potential biomarker that can be quickly detected by flow cytometry to predict disease trajectory at the time of diagnosis.
MOLECULAR ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Nabil Siraj, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: Men with papillary thyroid carcinoma are more likely to present with advanced and aggressive disease, and male sex is an independent prognostic factor for poor recurrence-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jiyu Meng, Xuelian Ruan, Fangyi Wei, Qin Xue
Summary: This study comprehensively assessed the expression and clinical relevance of ENPP2 in hepatocellular carcinoma (HCC). ENPP2 expression was found to be associated with clinical stage and is a significant prognostic factor for worse outcomes in HCC patients. The diagnostic value of ENPP2 expression in HCC was confirmed, and gene set enrichment analysis identified pathways enriched in HCC patients with high ENPP2 expression. Overall, ENPP2 is highly expressed in HCC and is a potential independent molecular marker for the diagnosis and prognosis of HCC.
Article
Biochemistry & Molecular Biology
Hao Yu, Liping Zhang, Xiaojuan He, Taohui Zhang, Chaolong Wang, Jiayu Lu, Xiaodong He, Keyi Chen, Weihang Gu, Siqi Cheng, Yang Hu, Bowen Yao, Anqi Jian, Xiaowen Yu, Hai Zheng, Shimin You, Qiming Wang, Dekun Lei, Ling Jiang, Zhigang Zhao, Jianmin Wan
Summary: This study identified a gene, OsPHS1, in rice that is involved in homologous chromosome recognition and pairing during meiosis. Mutations in OsPHS1 resulted in abnormal development of pollen and embryo sacs, leading to male and female sterility in rice plants. The findings suggest that OsPHS1 plays a crucial role in homologous chromosome pairing during rice gametogenesis.
Article
Oncology
Yu Shuai, Erxi Fan, Qiuyue Zhong, Qiying Chen, Guangyong Feng, Xiaoxia Gou, Guihai Zhang
Summary: High CDCA8 expression is a potential molecular predictor of poor prognosis in liver cancer. The level of CDCA8 expression is associated with T stage, clinical stage, histologic grade, and histological type in liver cancer, and high CDCA8 expression is correlated with a poor prognosis in liver cancer patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Saffron A. G. Willis-Owen, Clara Domingo-Sabugo, Elizabeth Starren, Liming Liang, Maxim B. Freidin, Madeleine Arseneault, Youming Zhang, Shir Kiong Lu, Sanjay Popat, Eric Lim, Andrew G. Nicholson, Yasser Riazalhosseini, Mark Lathrop, William O. C. Cookson, Miriam F. Moffatt
Summary: Lung cancer disproportionately affects men with KDM5D deficiency associated with a higher risk of death. The study identifies KDM5D deficiency as a prognostic marker for male lung cancer patients, explaining the sex disparity in lung cancer outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yong Liu, Yuelin Liu, Yong Gao, Lei Wang, Hengliang Shi, Chengmin Xuan
Summary: This study identified the regulatory pathway of H19 and hsa-miR-338-3P in regulating NRP1 expression in GBM, which plays an important role in the disease.
Review
Oncology
Hitomi Sakaguchi-Mukaida, Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Misooja Lee, Satoki Deguchi, Mina Sakata, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: This systematic review examines the effectiveness of neoadjuvant chemotherapy (NACT) for women with malignant ovarian germ cell tumors (MOGCT). The results indicate that NACT is used in approximately 40% of advanced MOGCT cases with a response rate of 95.8%. The uterine preservation rate is around 70% and the cumulative resumed menstruation rate is 100%. Comparisons with primary debulking surgery show similar overall survival, disease-free survival, recurrence rate, and adverse event rate from chemotherapy.
Article
Oncology
Andreas Marx, Lena Koopmann, Doris Haflmayer, Franziska Buescheck, Claudia Hube-Magg, Stefan Steurer, Till Eichenauer, Till S. Clauditz, Waldemar Wilczak, Ronald Simon, Guido Sauter, Jakob R. Izbicki, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Thorsten Schlomm, Christian Bernreuther, Patrick Lebok, Sarah Bonk
Summary: ANO7 protein expression is strongly associated with prostate epithelial cells and its reduced expression is closely linked to adverse tumor features, serving as a strong and independent predictor of poor prognosis in prostate cancer.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Oncology
Wenxue Li, Yujing Qin, Ruiqi Zhou, Yao Liu, Guiyu Zhang
Summary: The study revealed that SIX1 is overexpressed in endometrial cancer (EC) tissues, associated with adverse clinicopathological outcomes, and can serve as an independent factor affecting EC prognosis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Tomas Pokrivcak, Radek Lakomy, Tomas Kazda, Alexandr Poprach, Pavel Fabian, Igor Kiss
Summary: The article discusses the experience of using adjuvant chemotherapy BEP in high-risk patients after kidney transplantation, mentioning the safety and effectiveness of cisplatin in patients with CKD and kidney transplant.
Article
Oncology
Vera Miranda-Goncalves, Joao Lobo, Catarina Guimaraes-Teixeira, Daniela Barros-Silva, Rita Guimaraes, Mariana Cantante, Isaac Braga, Joaquina Mauricio, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique, Carmen Jeronimo
Summary: The study found significant differences in the expression of various m(6)A modifiers in cell lines representing different classes of GCTs, as well as changes after treatment with all-trans retinoic acid. Knockdown of VIRMA resulted in disruption of the methyltransferase complex, decreased m(6)A abundance, reduced tumor aggressiveness, and increased sensitivity to cisplatin treatment both in vitro and in vivo. Enhanced response to cisplatin after VIRMA knockdown was associated with increased DNA damage and downregulation of specific genes related to DNA repair.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Neuroimaging
May Zin Myint, Leonard L. L. Yeo, Benjamin Y. Q. Tan, Ei Zune The, Mei Chin Lim, Ching-Hui Sia, Hock-Luen Teoh, Vijay Kumar Sharma, Bernard Chan, Aftab Ahmad, Prakash Paliwal, Anil Gopinathan, Cunli Yang, Andrew Makmur, Tommy Andersson, Fabian Arnberg, Staffan Holmin
Summary: The study suggests that asymmetrical internal cerebral veins (ICV) on multiphasic CT angiogram (mCTA) may serve as an independent predictor for poor functional outcomes in patients undergoing EVT for anterior circulation large vessel occlusion (LVO) in acute ischemic stroke (AIS).
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Urology & Nephrology
J. Alberto Nakauma-Gonzalez, Maud Rijnders, Job van Riet, Michiel S. van der Heijden, Jens Voortman, Edwin Cuppen, Niven Mehra, Sandra van Wilpe, Sjoukje F. Oosting, L. Lucia Rijstenberg, Hans M. Westgeest, Ellen C. Zwarthoff, Ronald de Wit, Astrid A. M. van der Veldt, Harmen J. G. van de Werken, Martijn P. J. Lolkema, Joost L. Boormans
Summary: This study analyzed the molecular and genetic features of metastatic urothelial carcinoma (mUC) and identified different genomic and transcriptomic subtypes, providing potential therapeutic options for individualized treatment. The findings have significant clinical implications.
Article
Oncology
Youri Hoogstrate, Santoesha A. Ghisai, Maurice de Wit, Iris de Heer, Kaspar Draaisma, Job van Riet, Harmen J. G. van de Werken, Vincent Bours, Jan Buter, Isabelle Vanden Bempt, Marica Eoli, Enrico Franceschi, Jean-Sebastien Frenel, Thierry Gorlia, Monique C. Hanse, Ann Hoeben, Melissa Kerkhof, Johan M. Kros, Sieger Leenstra, Giuseppe Lombardi, Slavka Lukacova, Pierre A. Robe, Juan M. Sepulveda, Walter Taal, Martin Taphoorn, Rene M. Vernhout, Annemiek M. E. Walenkamp, Colin Watts, Michael Weller, Filip Y. F. de Vos, Guido W. Jenster, Martin van den Bent, Pim J. French
Summary: This study investigated the role of EGFRvIII in glioblastoma using multiple datasets. The results showed significant variations in EGFRvIII expression ratios among tumors. EGFRvIII expression was inversely correlated with pan-EGFR expression and exhibited higher potency in downstream pathway activation. Glioblastomas with EGFRvIII had a lower incidence of CDK4 or MDM2 amplification compared to EGFRvIII-negative tumors.
Article
Oncology
Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak-Rothkamm, Malik Alawi, Christian Mueller, Ulrich Schueller, Tobias Maurer, Gunhild von Amsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Summary: This study provides preclinical models for castration-resistant prostate cancer (CRPC) that can predict homologous recombination repair (HRR) defects and the sensitivity to olaparib and cisplatin. These models recapitulate the features of primary tumors, enabling individualized drug screening for tailored therapy recommendations.
MOLECULAR ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Wesley S. van de Geer, Ron H. J. Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, Lot A. Devriese, Vivianne C. G. Tjan-Heijnen, Emile E. Voest, Stefan Sleijfer, John W. M. Martens, Edwin Cuppen, Harmen J. G. van de Werken, Sander Bins
Summary: Drug resistance is a persistent problem in cancer therapy, and alterations in drug transport over the cancer cell membrane can contribute to resistance. This study analyzed the mutational landscape of transporter genes in cancer patients who had received different systemic therapies, and identified potential stressor mechanisms that may be involved in drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Sabine E. Hannema, Katja P. Wolffenbuttel, Yolande van Bever, Hennie T. Bruggenwirth, Sjoerd A. A. van den Berg, Remko Hersmus, J. Wolter Oosterhuis, Leendert H. J. Looijenga
Summary: Individuals with 45,X/46,XY or 46,XY gonadal dysgenesis have an increased risk of germ cell malignancies. This study aimed to determine if undetectable preoperative serum anti-Mullerian hormone (AMH) and inhibin B can predict the absence of germ cells or (pre)malignant conditions. The results suggest that undetectable AMH and inhibin B cannot reliably predict the absence of germ cells in individuals with gonadal dysgenesis. Rating: 8/10.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan Diego Sanchez Vasquez, Nadia Conceicao-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M. A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Kurt Spittaels, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L. A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex K. Shalek, Adam J. Gehring
Summary: This study aims to comprehensively compare the immune cells in the blood and liver of patients with chronic hepatitis B using single-cell RNA sequencing, in order to identify biomarkers for intrahepatic immune activity. The results show that both Seq-Well S3 and 10x Chromium technologies can capture the cellular diversity of the liver, but Seq-Well S3 is more effective in capturing neutrophils that are absent in the 10x dataset. CD8 T cells and neutrophils show distinct gene expression profiles between blood and liver.
Review
Biochemistry & Molecular Biology
Joaquin Montilla-Rojo, Monika Bialecka, Kimberley E. E. Wever, Christine L. L. Mummery, Leendert H. J. Looijenga, Bernard A. J. Roelen, Daniela C. F. Salvatori
Summary: Pluripotency is crucial for assessing stem cells, but there is a lack of standardization in the teratoma assay and ethical concerns about animal use. In vitro alternatives have been developed, but their use and malignancy testing remain limited. The teratoma assay is still preferred for safety assessment, highlighting the need for an in vitro assay for testing stem cell malignancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Summary: This study provides multi-omics profiling of malignant germ cell tumors (GCTs) across different age groups, showing that the WNT signaling pathway is activated in GCTs and is associated with poor clinical outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Daphne P. C. Vergouwen, Amber J. J. Schotting, Tanja Endermann, Harmen J. G. van de Werken, Dwin G. B. Grashof, Sinthuja Arumugam, Rudy M. M. A. Nuijts, Josianne C. C. ten Berge, Aniki Rothova, Marco W. J. Schreurs, Marlies Gijs
Summary: Tear fluid collected via Schirmer strips has the potential for biomarker identification, but the lack of knowledge on strip processing complicates analysis and comparisons between studies. In this study, we compared two preprocessing methods and found that the punch method yielded higher protein detectability than the elution method. Protein expression levels were slightly higher in the head of the strip, but 3 out of 5 punches from the head failed quality control. Our study suggests the beneficial use of punches from any part of the strip except the head in future biomarker research.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Oncology
C. Oing, R. G. Bristow
Article
Multidisciplinary Sciences
K. de Joode, W. S. van de Geer, G. J. L. H. van Leenders, P. Hamberg, H. M. Westgeest, A. Beeker, S. F. Oosting, J. M. van Rooijen, L. V. Beerepoot, M. Labots, R. H. J. Mathijssen, M. P. Lolkema, E. Cuppen, S. Sleijfer, H. J. G. van de Werken, A. A. M. van der Veldt
Summary: Differences in the clinical course and treatment responses in individual patients with advanced renal cell carcinoma (RCC) can largely be explained by the different genomics of this disease. Whole-genome sequencing (WGS) and RNA sequencing (RNA-Seq) data analysis can identify putative actionable drug targets and immune gene expression patterns for personalized treatment strategies. By improving histological subtyping and treatment selection based on actionable targets and immune signatures, WGS and RNA-Seq may improve therapeutic decision making for most patients with advanced RCC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Manzhi Zhao, Ling Li, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Floris Dammeijer, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Joachim G. Aerts, Yvonne M. Mueller, Peter D. Katsikis
Summary: Modulating chronic antigen stimulation and T-cell receptor signaling with an ITK inhibitor can reverse ICB resistance in solid tumors and enhance the effectiveness of ICB therapy.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Ling Li, Manzhi Zhao, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Yvonne M. Mueller, Peter D. Katsikis
Summary: This study demonstrates that ibrutinib directly ameliorates CTL exhaustion by reducing inhibitory receptor expression, enhancing cytokine production, and modulating the transcription factors TOX and TCF1. Additionally, the effect of ibrutinib is independent of BTK expression, suggesting the involvement of other targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Francis S. P. L. Wens, Caroline C. C. Hulsker, Marta Fiocco, Jozsef Zsiros, Stephanie E. Smetsers, Ronald R. de Krijger, Alida F. W. van der Steeg, Ronald P. Zweemer, Inge O. Baas, Eva Maria Roes, Leendert H. J. Looijenga, Cornelis G. Gerestein, Annelies M. C. Mavinkurve-Groothuis
Summary: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive ovarian cancer with a poor prognosis. More research and international collaboration are needed to improve the treatment and outcome for SCCOHT patients. Mutations in the SMARCA4 gene play a crucial role in accurate diagnosis and may lead to new treatment options.
Article
Medicine, General & Internal
Barbara Rentroia-Pacheco, Selin Tokez, Edo M. Bramer, Zoe C. Venables, Harmen J. G. van de Werken, Domenico Bellomo, David van Klaveren, Antien L. Mooyaart, Loes M. Hollestein, Marlies Wakkee
Summary: A clinico-pathological model was developed to predict metastasis in cSCC patients, showing good discriminative ability and calibration. The model provides personalized metastatic risk predictions, which can be used for clinical decision-making and personalized care.