Article
Multidisciplinary Sciences
Kazim Husain, Domenico Coppola, Chung S. Yang, Mokenge P. Malafa
Summary: FDMC inhibits the growth and metastasis of colon cancer stem cells, reducing key processes of tumor growth and metastasis, and exhibiting anti-tumor effects in in vivo models.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yusuke Asada, Katsuya Chinen, Ken Yamataka, Jo Tokuyama, Naoto Kurihara, Shuhei Iida
Summary: This is a rare case of intramural recurrence in colorectal cancer, with distant metastasis in the rectum. PET-CT and short-interval repeat colonoscopy can improve detection of intramural recurrence. A long distal margin should be preserved during surgery to prevent recurrence.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Yunus Akkoc, Nesibe Peker, Arzu Akcay, Devrim Gozuacik
Summary: Metastasis and relapse are the main causes of cancer-related deaths. Dormant cancer cells are able to evade conventional treatments, with autophagy playing a crucial role in the adaptation, survival, and reactivation of these cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Taohua Yue, Jichang Li, Jing Zhu, Shuai Zuo, Xin Wang, Yucun Liu, Jia Liu, Xiaoyun Liu, Pengyuan Wang, Shanwen Chen
Summary: Immunotherapy can be effective in treating cancer, but many colorectal cancer patients do not respond to it. This study shows that reducing H2S levels can help reverse the tumor-supportive functions and improve the efficacy of immunotherapy.
Article
Oncology
A. Kulkarni, N. M. Andrews Wright, A. N. Forget, T. Ramsay, R. Mallick, J. I. Weberpals
Summary: The purpose of this study is to determine primary survival endpoints in women with recurrent and metastatic endometrial carcinoma treated with progestins. The study found that there may be a role for progestins in select subgroups of women.
Article
Oncology
Frank C. Cackowski, Elisabeth I. Heath
Summary: Prostate cancer has the unique ability to lie dormant and recur long after treatment, with important reservoirs for dormant tumor cells in the bone marrow, lymph nodes, and the prostate bed. The induction of cellular dormancy in prostate cancer cells involves complex signaling pathways and interactions with the microenvironment, and current adjuvant therapies are only modestly successful in preventing recurrence, indicating the need for further advancements in systemic adjuvant therapy.
Review
Medicine, General & Internal
Ling-Kang Meng, Dan Zhu, Yu Zhang, Yuan Fang, Wei-Zhen Liu, Xia-Qing Zhang, Yong Zhu
Summary: Colorectal cancer metastasis to the anus is rare, with low recurrence rates. This case reports a recurrence after 10 years, highlighting the risk. Literature review and discussion of potential mechanisms provide treatment suggestions.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Biochemistry & Molecular Biology
Md Rezaul Islam, Shopnil Akash, Md Mominur Rahman, Feana Tasmim Nowrin, Tamanna Akter, Sheikh Shohag, Abdur Rauf, Abdullah S. M. Aljohani, Jesus Simal-Gandara
Summary: Colon cancer is the world's second leading cause of cancer-related deaths, and its death rates have increased due to modern lifestyle. Natural compounds in medicinal plants show potential in combating colon cancer through activation of signaling pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Oncology
Justin C. Brown, Chao Ma, Qian Shi, Tyler Zemla, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Victor Chang, Richard M. Goldberg, Alan P. Venook, Charles D. Blanke, Eileen M. O'Reilly, Anthony F. Shields, Jeffrey A. Meyerhardt
Summary: This study aimed to investigate whether physical activity during and after postoperative chemotherapy for stage III colon cancer improves overall survival after tumor recurrence. The study found that higher postoperative physical activity is associated with improved overall survival in patients initially diagnosed with stage III colon cancer.
Article
Medicine, General & Internal
Jeanne Tie, Joshua D. Cohen, Kamel Lahouel, Serigne N. Lo, Yuxuan Wang, Suzanne Kosmider, Rachel Wong, Jeremy Shapiro, Margaret Lee, Sam Harris, Adnan Khattak, Matthew Burge, Marion Harris, James Lynam, Louise Nott, Fiona Day, Theresa Hayes, Sue-Anne McLachlan, Belinda Lee, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Maria Popoli, Ralph Hruban, Anne Marie Lennon, Nicholas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Cristian Tomasetti, Peter Gibbs
Summary: This study found that using ctDNA results to guide treatment decisions for stage II colon cancer reduced the use of adjuvant chemotherapy without compromising recurrence-free survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Surgery
Jung Hoon Bae, Ji Hoon Kim, Bong-Hyeon Kye, Abdullah Al-Sawat, Chul Seung Lee, Seung-Rim Han, In Kyu Lee, Sung Hak Lee, Yoon Suk Lee
Summary: In patients with non-metastatic colon cancer, vascular invasion (VI) and lymph node metastasis (LNM) independently impact disease-free survival (DFS). There is a comparable 5-year DFS rate between the VI-/LNM+ and VI+/LNM- groups, but DFS deteriorates in the order of IIIA, II, and IIIB when the VI-/LNM+ group is further subdivided by nodal staging.
FRONTIERS IN SURGERY
(2021)
Article
Urology & Nephrology
Nicholas H. Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A. Ornellas, Mario Catanzaro, Oliver W. Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E. Spiess
Summary: This study found that 31.9% of pSCC patients experienced post-ILND recurrence, which was associated with high pN staging. Over 95% of distant, inguinal, and pelvic recurrences occurred within 48 months post-ILND. Local recurrences occurred over a longer timeline, highlighting the necessity of long-term surveillance of the primary site.
JOURNAL OF UROLOGY
(2021)
Article
Multidisciplinary Sciences
Jiexi Li, Zhengdao Lan, Wenting Liao, James W. W. Horner, Xueping Xu, Jielin Liu, Yohei Yoshihama, Shan Jiang, Hong Seok Shim, Max Slotnik, Kyle A. A. LaBella, Chang-Jiun Wu, Kenneth Dunner Jr, Wen-Hao Hsu, Rumi Lee, Isha Khanduri, Christopher Terranova, Kadir Akdemir, Deepavali Chakravarti, Xiaoying Shang, Denise J. J. Spring, Y. Alan Wang, Ronald A. A. DePinho
Summary: Sex plays an important role in cancer incidence, spectrum, and outcomes, particularly in colorectal cancer (CRC) where men have higher metastases and mortality rates. A study using a murine CRC model revealed that oncogenic mutant KRAS (KRAS*) CRC in males showed higher metastases and worse outcomes. Further analysis found that the Y-chromosome gene histone demethylase KDM5D, driven by KRAS*-mediated activation of the STAT4 transcription factor, contributed to the sex differences in KRAS* CRC. Deletion of Kdm5d in cancer cells improved tight junction integrity, reduced invasiveness, and enhanced cancer cell killing by CD8(+) T cells. On the contrary, mice with a Kdm5d transgene had a higher propensity for invasive tumors. Therefore, the upregulation of Y chromosome KDM5D via KRAS*-STAT4 pathway disrupts cancer cell adhesion properties and tumor immunity, providing a potential therapeutic strategy for reducing metastasis risk in men with KRAS* CRC.
Article
Oncology
Josanne S. de Maar, Marianne Luyendijk, Britt B. M. Suelmann, Dave E. W. van der Kruijssen, Sjoerd G. Elias, Sabine Siesling, Elsken van der Wall
Summary: This study aimed to compare characteristics and survival of patients with de novo and metachronous metastatic breast cancer. Data from the Netherlands Cancer Registry were used to categorize patients into de novo or metachronous metastatic breast cancer groups. The study found differences in clinicopathological characteristics and survival between these two groups.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Sarah R. Verhoeff, Sjoukje F. Oosting, Sjoerd G. Elias, Suzanne C. van Es, Sophie L. Gerritse, Lindsay Angus, Sandra Heskamp, Ingrid M. E. Desar, C. Willemien Menke-van der Houven van Oordt, Astrid A. M. van der Veldt, Anne I. J. Arens, Adrienne H. Brouwers, Bertha Eisses, Peter F. A. Mulders, Otto S. Hoekstra, Gerben J. C. Zwezerijnen, Winette T. A. van der Graaf, Erik H. J. G. Aarntzen, Wim J. G. Oyen, Carla M. L. van Herpen
Summary: Patients with metastatic clear-cell renal cell carcinoma (mccRCC) with good or intermediate prognosis can consider watchful waiting (WW), especially those who meet the watch and wait (W&W) criteria of < 2 International Metastatic RCC Database Consortium criteria and <=2 metastatic sites. This study aimed to assess the predictive value of [F-18]FDG PET/CT and [Zr-89]Zr-DFO-girentuximab PET/CT for the duration of WW in patients with mccRCC.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Dave E. W. van Der Kruijssen, Auke J. S. van Der Kuil, Geraldine R. Vink, Cornelis J. A. Punt, Johannes H. W. de Wilt, Sjoerd G. Elias, Miriam Koopman
Summary: This study investigated the prognostic value of primary tumor sidedness in metastatic colorectal cancer over time and across treatment lines. Population data and prospective studies were examined to determine the time-varying nature of sidedness and its influence on prognosis. The results suggest that the prognostic value of primary tumor sidedness decreases over time and varies depending on the treatment line.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Cell Biology
Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Summary: Polyploid cells, containing more than one set of chromosome pairs, are common in nature. They provide cells with several advantages, including increased cell size, organ growth, tissue homeostasis, and enhanced tolerance to genomic stress and apoptotic signals. This article focuses on the reasons for polyploidy, the stress responses and molecular signals involved, as well as its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
Article
Oncology
Isabella A. J. van Duin, Sjoerd G. Elias, Alfonsus J. M. van den Eertwegh, Jan Willem B. de Groot, Willeke A. M. Blokx, Paul J. van Diest, Tim Leiner, Joost J. C. Verhoeff, Rik J. Verheijden, Olivier J. van Not, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Christian U. Blank, John B. A. G. Haanen, Geke A. P. Hospers, Anna M. Kamphuis, Djura Piersma, Rozemarijn S. van Rijn, Astrid A. M. van Der Veldt, Gerard Vreugdenhil, Michel W. J. M. Wouters, Marion A. M. Stevense-den Boer, Marye J. Boers-Sonderen, Ellen Kapiteijn, Karijn P. M. Suijkerbuijk
Summary: Since the introduction of BRAF(/MEK) inhibition and immune checkpoint inhibition (ICI), the prognosis of advanced melanoma has greatly improved. We investigated the relationship between time to first distant recurrence (TFDR) and patient outcomes after systemic treatment for advanced melanoma. The results showed that patients with a longer TFDR have prolonged PFS and OS, regardless of the type of treatment they received.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Nazma F. Ilahibaks, Arif I. Ardisasmita, Songpu Xie, Anders Gunnarsson, Joseph Brealey, Pieter Vader, Olivier G. de Jong, Saskia de Jager, Niek Dekker, Ben Peacock, Raymond M. Schiffelers, Joost P. G. Sluijter, Zhiyong Lei
Summary: Extracellular vesicles (EVs) are being explored as biocompatible drug delivery vehicles for their ability to deliver bioactive cargo to recipient cells. However, effective methods for loading and unloading proteins inside EVs remain a challenge. In this study, we present the Technology Of Protein delivery through Extracellular Vesicles (TOP-EVs) as an efficient tool for intracellular protein delivery mediated by EVs. Our results demonstrate the versatility and potential of TOP-EVs for protein-based therapeutics in vitro and in vivo.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Max A. A. Ragusi, Bas H. M. van der Velden, Carla Meeuwis, Eric Tetteroo, Emile G. Coerkamp, Thiemo J. A. van Nijnatten, Frits H. Jansen, Elian J. M. Wolters-van der Ben, Lisa Jongen, Fleur van Raamt, Monique D. Dorrius, Janneke Verloop, Max A. Viergever, Ruud M. Pijnappel, Sjoerd G. Elias, Kenneth G. A. Gilhuijs
Summary: A multicenter retrospective cohort study was conducted to confirm the association between contralateral parenchymal enhancement (CPE) and long-term survival in patients with ER-positive and HER2-negative breast cancer. The study also aimed to investigate the relationship between CPE and endocrine therapy effectiveness.
Article
Medicine, General & Internal
Maaike E. Verweij, Max D. Tanaka, Chavelli M. Kensen, Uulke A. van der Heide, Corrie A. M. Marijnen, Tomas Janssen, Tineke Vijlbrief, Wilhelmina M. U. van Grevenstein, Leon M. G. Moons, Miriam Koopman, Miangela M. Lacle, Manon N. G. J. A. Braat, Myriam Chalabi, Monique Maas, Inge L. Huibregtse, Petur Snaebjornsson, Brechtje A. Grotenhuis, Remond Fijneman, Esther Consten, Apollo Pronk, Anke B. Smits, Joost T. Heikens, Hidde Eijkelenkamp, Sjoerd G. Elias, Helena M. Verkooijen, Maartje M. C. Schoenmakers, Gert J. Meijer, Martijn Intven, Femke P. Peters
Summary: This study aims to establish the maximum tolerated dose of dose-escalated short-course radiotherapy using online adaptive magnetic resonance-guided radiotherapy in patients with intermediate-risk rectal cancer. The primary endpoint is the maximum tolerated dose based on the incidence of dose-limiting toxicity. Secondary endpoints include the organ preservation rate, oncological outcomes, patient-reported quality of life, and functional outcomes.
Article
Immunology
Esther Strating, Mathijs P. P. Verhagen, Emerens Wensink, Ester Duennebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez de la Cruz, Niek A. A. Peters, Joris H. H. Hageman, Mirjam M. C. van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G. G. Elias, Onno Kranenburg
Summary: A co-culture model system of colon cancer organoids and cancer-associated fibroblasts (CAFs) was established, which can recapitulate the histological, biophysical, and immunosuppressive features of aggressive mesenchymal-like human colorectal cancer (CRC). This model can be used to study the mechanisms of immunosuppression and test therapeutic strategies targeting the interaction between CAFs and cancer cells. Furthermore, it can be modified to represent different colon cancer subtypes and (organ-specific) microenvironments.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Laura E. Swart, Marcel H. A. M. Fens, Anita van Oort, Piotr Waranecki, L. Daniel Mata Casimiro, David Tuk, Martijn Hendriksen, Luca van den Brink, Elizabeth Schweighart, Cor Seinen, Ryan Nelson, Anja Krippner-Heidenreich, Tom O'Toole, Raymond M. Schiffelers, Sander Kooijmans, Olaf Heidenreich
Summary: Lipid nanoparticles (LNPs) are rapidly evolving as promising delivery systems for oligonucleotides, including siRNAs. In this study, LNPs were specifically targeted to hematopoietic progenitor cells in the bone marrow using a modified tripeptide ligand. Functionalized LNPs showed improved uptake and delivery of siRNA in patient-derived leukemia cells, as well as increased accumulation and retention in the bone marrow. These findings suggest the potential of LNPs for targeted therapy in leukemia and other hematological disorders.
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
C. M. van Kammen, S. J. van Woudenberg, R. Schiffelers, F. Terstappen, A. T. Lely
Summary: Preeclampsia and fetal growth restriction are pregnancy complications that can be treated with nanomedicines, which regulate drug interaction with the placenta to enhance treatment efficacy and minimize fetal exposure. Liposomes and polymeric drug delivery systems show promising results in preventing trans-placental passage of nanomedicines, while quantum dots and silicon nanoparticles have limited research in placental insufficiency syndromes. Animal studies demonstrate positive effects on maternal and fetal health, but results are influenced by various factors. Further research is needed to understand the pathophysiology of these complex diseases and ensure the safety and efficacy of nanomedicines before clinical implementation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Gastroenterology & Hepatology
Anouk M. Wijnands, Sjoerd G. Elias, Evelien Dekker, Herma H. Fidder, Frank Hoentjen, Joren R. ten Hove, P. W. Jeroen Maljaars, Andrea E. van der Meulen-de Jong, Erik Mooiweer, Renske J. Ouwehand, Bas B. L. Penning de Vries, Cyriel Y. Ponsioen, Fiona D. M. van Schaik, Bas Oldenburg
Summary: This study aimed to clarify the association between smoking and the development of colorectal neoplasia in patients with inflammatory bowel disease (IBD). The results showed that smoking was not associated with the risk of recurrent colorectal neoplasia, but an increasing number of pack-years was associated with a higher risk of recurrence.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Esther Strating, Anne van de Loo, Sjoerd Elias, Marnix Lam, Onno Kranenburg
Article
Chemistry, Multidisciplinary
Ye Zeng, Mariona Estape Senti, M. Clara I. Labonia, Panagiota Papadopoulou, Maike A. D. Brans, Inge Dokter, Marcel H. Fens, Alain van Mil, Joost P. G. Sluijter, Raymond M. Schiffelers, Pieter Vader, Alexander Kros
Summary: This study demonstrates the efficient delivery of mRNA-LNPs to difficult-to-transfect cardiomyocytes using fusogenic coiled-coil peptides. Local administration via intramyocardial injection significantly enhances mRNA delivery and protein expression. These findings have the potential to advance regenerative therapies for heart failure.