Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

Macrophage migration inhibitory factor‐ CD 74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells

(2019) Masako Imaoka et al.   CANCER SCIENCE

Rediscovering MIF: New Tricks for an Old Cytokine

(2019) James Harris et al.   TRENDS IN IMMUNOLOGY

Role of Macrophage Migration Inhibitory Factor (MIF) in Melanoma

(2019) Laura Soumoy et al.   Cancers

Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

(2018) Amanda Sparkes et al.   FASEB JOURNAL

Contribution of the macrophage migration inhibitory factor superfamily of cytokines in the pathogenesis of preclinical and human multiple sclerosis: In silico and in vivo evidences

(2018) Paolo Fagone et al.   JOURNAL OF NEUROIMMUNOLOGY

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

(2018) Tali Lang et al.   Nature Communications

Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

(2018) Katia Mangano et al.   Oncotarget

Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4

(2018) Michael Lacy et al.   Scientific Reports

Macrophage migration inhibitory factor regulates U1-snRNP immune complex mediated activation of the NLRP3 inflammasome

(2018) Min Sun Shin et al.   Arthritis & Rheumatology

Review: The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine

(2018) Sungyong You et al.   Arthritis & Rheumatology

Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

(2018) Carlos R. Figueiredo et al.   Frontiers in Immunology

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble CD74 Reroutes MIF/CXCR4/AKT‐Mediated Survival of Cardiac Myofibroblasts to Necroptosis

(2018) Josefin Soppert et al.   Journal of the American Heart Association

Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets

(2018) Sven Günther et al.   DRUG DISCOVERY TODAY

Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis

(2017) Aisling Tynan et al.   FASEB JOURNAL

The non-mammalian MIF superfamily

(2017) Amanda Sparkes et al.   IMMUNOBIOLOGY

Associations between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis, and betweenMIFgene polymorphisms and disease susceptibility: a meta-analysis

(2017) Sang-Cheol Bae et al.   POSTGRADUATE MEDICAL JOURNAL

MIF and D-DT are potential disease severity modifiers in male MS subjects

(2017) Gil Benedek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-dopachrome tautomerase is over-expressed in pancreatic ductal adenocarcinoma and acts cooperatively with macrophage migration inhibitory factor to promote cancer growth

(2016) Dawei Guo et al.   INTERNATIONAL JOURNAL OF CANCER

Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus

(2016) Jie Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout

(2016) Izabela Galvão et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting MIF in Cancer: Therapeutic Strategies, Current Developments, and Future Opportunities

(2016) Ciaran O'Reilly et al.   MEDICINAL RESEARCH REVIEWS

Predicted structure of MIF/CD74 and RTL1000/CD74 complexes

(2016) Roberto Meza-Romero et al.   METABOLIC BRAIN DISEASE

Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis

(2016) Athina Savva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MIFallele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

(2016) Seung-Ah Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus

(2016) K. L. Connelly et al.   Scientific Reports

An Analysis of MIF Structural Features that Control Functional Activation of CD74

(2015) Georgios Pantouris et al.   CHEMISTRY & BIOLOGY

Macrophage migration inhibitory factor is essential for osteoclastogenic mechanisms in vitro and in vivo mouse model of arthritis

(2015) Ran Gu et al.   CYTOKINE

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

(2015) Setareh Alampour-Rajabi et al.   FASEB JOURNAL

The Integral Role of CD74 in Antigen Presentation, MIF Signal Transduction, and B Cell Survival and Homeostasis

(2015) Richard Bucala et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Beyond apoptosis in lupus

(2014) Lucrezia Colonna et al.   CURRENT OPINION IN RHEUMATOLOGY

Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment

(2014) Deepa Rajasekaran et al.   FASEB JOURNAL

The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury

(2014) Dake Qi et al.   JOURNAL OF CLINICAL INVESTIGATION

HLA-DR 1 Constructs Block CD74 Expression and MIF Effects in Experimental Autoimmune Encephalomyelitis

(2014) R. Meza-Romero et al.   JOURNAL OF IMMUNOLOGY

Macrophage migration inhibitory factor (MIF): Genetic evidence for participation in early onset and early stage rheumatoid arthritis

(2013) M.A. Llamas-Covarrubias et al.   CYTOKINE

The role of macrophage migration inhibitory factor in autoimmune liver disease

(2013) David N. Assis et al.   HEPATOLOGY

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis

(2013) R. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-dopachrome tautomerase (D-DT or MIF-2): Doubling the MIF cytokine family

(2012) Melanie Merk et al.   CYTOKINE

A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)

(2012) Fengwei Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

(2012) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

(2012) Soi Law et al.   ARTHRITIS RESEARCH & THERAPY

New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus

(2012) Fang-Fang Wang et al.   ARTHRITIS RESEARCH & THERAPY

Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus

(2011) Antoine Sreih et al.   ARTHRITIS AND RHEUMATISM

Benzisothiazolones as modulators of macrophage migration inhibitory factor

(2011) William L. Jorgensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma

(2011) L. Alinari et al.   BLOOD

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

(2011) M. Merk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced arthritis in MIF deficient mice is associated with reduced T cell activation: down-regulation of ERK MAP kinase phosphorylation

(2010) L. L. Santos et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Autoimmune diseases: MIF as a therapeutic target

(2010) Dorothee Greven et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

(2010) Sandra Kraemer et al.   FASEB JOURNAL

Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action

(2010) Hajer Ouertatani-Sakouhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74

(2010) M. Gordin et al.   JOURNAL OF IMMUNOLOGY

Macrophage Migration Inhibitory Factor Increases Leukocyte-Endothelial Interactions in Human Endothelial Cells via Promotion of Expression of Adhesion Molecules

(2010) Q. Cheng et al.   JOURNAL OF IMMUNOLOGY

A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice

(2010) L. Leng et al.   JOURNAL OF IMMUNOLOGY

RTL therapy for multiple sclerosis: A Phase I clinical study

(2010) Halina Offner et al.   JOURNAL OF NEUROIMMUNOLOGY

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

(2010) Y. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia

(2009) Sachin Yende et al.   FASEB JOURNAL

A functional heteromeric MIF receptor formed by CD74 and CXCR4

(2009) Verena Schwartz et al.   FEBS LETTERS

The Golgi-Associated Protein p115 Mediates the Secretion of Macrophage Migration Inhibitory Factor

(2009) M. Merk et al.   JOURNAL OF IMMUNOLOGY

A Tautomerase-Null Macrophage Migration-Inhibitory Factor (MIF) Gene Knock-In Mouse Model Reveals That Protein Interactions and Not Enzymatic Activity Mediate MIF-Dependent Growth Regulation

(2009) G. Fingerle-Rowson et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

(2008) M. Winner et al.   CANCER RESEARCH

Macrophage migration inhibitory factor: A key cytokine in RA, SLE and atherosclerosis

(2008) Leilani L. Santos et al.   CLINICA CHIMICA ACTA

Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii

(2008) Marcos Flores et al.   FASEB JOURNAL

Macrophage migration inhibitory factor stimulates interleukin-17 expression and production in lymph node cells

(2008) Ivana Stojanović et al.   IMMUNOLOGY

Discovery of Human Macrophage Migration Inhibitory Factor (MIF)-CD74 Antagonists via Virtual Screening

(2008) Zoe Cournia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

(2008) C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA