Article
Pharmacology & Pharmacy
Si Gou, Sergio del Rio-Sancho, Hans-Joachim Laubach, Yogeshvar N. Kalia
Summary: This study investigated the use of Erbium:YAG fractional laser ablation and different topical dosage forms to improve the delivery of PTX for skin fibrosis treatment. The results showed that fractional laser ablation significantly increased PTX delivery, with the hydrogel formulation being the optimal choice. By reducing the amount of hydrogel applied, PTX delivery efficiency was further improved.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Dermatology
Rikke L. Christensen, Silje H. Omland, Daniel P. Persson, Soren Husted, Merete Haedersdal, Uffe H. Olesen
Summary: This study investigated the uptake and biodistribution of topically delivered nivolumab assisted by physical enhancement techniques in porcine skin. Results showed that both ablative fractional laser-assisted passive diffusion and immediate electronically controlled pneumatic injection resulted in significantly enhanced uptake of nivolumab in the skin. The findings suggest the potential for delivering therapeutic antibodies locally using energy-based devices.
LASERS IN SURGERY AND MEDICINE
(2021)
Article
Surgery
Juliana de Filippi Sartori, Tammy Hentona Osaki, Midori Hentona Osaki, Rodrigo Barbosa de Souza, Norma Allemann
Summary: The study found that periorbital fractional CO2 laser resurfacing is an effective method for improving eyelid skin. Histochemical analysis showed an increase in collagen types I and III.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Dermatology
Woraphong Manuskiatti, Arisa Kaewkes, Chadakan Yan, Janice Natasha Ng, Joshua Zev Glahn, Rungsima Wanitphakdeedecha
Summary: The study demonstrated that fractional laser monotherapy is effective for hypertrophic scars, and the application of topical corticosteroid does not provide a long-term synergistic effect to fractional laser monotherapy.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Pharmacology & Pharmacy
Sabrina Valetti, Hanna Thomsen, Jitendra Wankar, Peter Falkman, Ilse Manet, Adam Feiler, Marica B. Ericson, Johan Engblom
Summary: Research has shown that porous particles of appropriate size and porosity can accumulate in hair follicles and furrows on the skin, providing a potential area for drug delivery. The combination of follicle orifices and furrows can cover up to 20% of the skin surface, making them valuable for optimizing bioavailability of topical formulations. This work highlights the potential of skin furrows for topical drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Patrycja Szumala, Adam Macierzanka
Summary: This review focuses on recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity. Permeation of therapeutic macromolecules can be increased by the correct design of the microemulsion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Mingyue Cui, Christian Wiraja, Sharon Wan Ting Chew, Chenjie Xu
Summary: Topical drug delivery has advantages over other routes, but the stratum corneum poses a challenge. Nanotechnology offers opportunities to overcome this challenge with nanocarriers like liposomes and nanoparticles. These formulations show potential in treating skin disorders, with further developments needed.
MOLECULAR PHARMACEUTICS
(2021)
Article
Dermatology
Nasrin Mani, Franja Pajk, Zdenko Vizintin
Summary: The combination of fractional and full spot ablative Er:YAG laser is a safe and effective option for full-face resurfacing. Postoperative re-epithelization lasted on average 6.4 days, and post-treatment erythema lasted on average 13.8 days. 96% of cases were treated in a single session, with 78% of patients showing improvement according to blinded assessment of photographs and 97% of patients satisfied with the treatment results.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nivedita Pant, Sarika Wairkar
Summary: Bioflavonoids are naturally derived compounds with various pharmacological actions. However, their low solubility and poor skin penetration limit their therapeutic applications for skin ailments. Nanocrystals of bioflavonoids have been developed to overcome these limitations. This review focuses on the preparation methods, in vitro evaluation, and animal studies of topical nanocrystals of bioflavonoids for different skin ailments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Yiwen Zhao, Jewel Voyer, Yibo Li, Xinliang Kang, Xinyuan Chen
Summary: This review discusses the application of ablative fractional laser (AFL) in facilitating topical drug delivery, including transdermal, transungual, and transocular drug delivery. AFL has been found to be safe and effective in enhancing drug delivery, reducing treatment time, and improving treatment outcomes.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Dermatology
Michael Wang-Evers, Alyre J. Blazon-Brown, Linh Ha-Wissel, Valeriya Arkhipova, Dilip Paithankar, Ilya Yaroslavsky, Gregory Altshuler, Dieter Manstein
Summary: The novel DFG system examined in this study generated deeper and narrower ablative lesions compared to other laser systems. Its small footprint design allows for control over ablation depth and surrounding coagulation, making it suitable for designing new treatment procedures.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng-Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang, Katerina Vavrova, Jonathan F. Lovell, Yumiao Zhang
Summary: This study finds that cabazitaxel (CTX) can be dissolved in alpha-tocopherol at high concentrations exceeding 100 mg mL(-1). The addition of 30% dimethyl sulfoxide (DMSO) to the alpha-tocopherol/CTX solution improves its permeation through human skin. Topical application of CTX using a DMSO and alpha-tocopherol solvent shows significant suppression of tumor growth in nude mice bearing skin cancer xenografts.
Article
Pharmacology & Pharmacy
Fotis Iliopoulos, Chun Fung Tang, Ziyue Li, Annisa Rahma, Majella E. Lane
Summary: The evaluation of bioequivalence (BE) for topical dermatological drug products is challenging, and the aim of this study was to evaluate the use of Confocal Raman Spectroscopy (CRS) for BE assessment. Two commercially available formulations were found to deliver similar amounts of drug across the skin in vitro and resulted in comparable skin uptake values in vivo. This is the first study to demonstrate the capability of CRS for the evaluation of BE for topical products.
Article
Multidisciplinary Sciences
Haoran Guo, Xiangyu Zhang, Hui Li, Chuhan Fu, Ling Jiang, Yibo Hu, Jinhua Huang, Jing Chen, Qinghai Zeng
Summary: Fractional CO2 laser is commonly used in the treatment of various skin diseases. This study investigated the changes in skin function and regulatory mechanisms after fractional CO2 laser treatment. The results showed that the laser transformed the lesions into normal skin, regulated the skin barrier, rearranged collagen, enhanced local microvascular circulation, activated the immune system, and aided drug transport.
Review
Biochemistry & Molecular Biology
Janaina Artem Ataide, Julia Cedran Coco, Erica Mendes dos Santos, Viviane Beraldo-Araujo, Jessica Ribeiro Alves Silva, Karine Cappuccio de Castro, Andre Moreni Lopes, Nina Filipczak, Satya Siva Kishan Yalamarty, Vladimir P. P. Torchilin, Priscila Gava Mazzola
Summary: The main goal of medicine is to achieve the best possible outcome for therapy. Nanocarriers and co-delivery strategies have been invented to meet this need, benefiting not only cancer treatment but also many other clinical issues, especially skin diseases. This review aims to summarize the research state of nanocarriers and co-delivery strategies for topical agents' applications targeting skin diseases. The challenge for future medicine lies in delivering drugs with spatial and temporal control, and the co-encapsulation of drugs and appropriate administration forms are important and unmet needs.
Article
Pharmacology & Pharmacy
Mohammad Javed Ansari, Mohammed Alnakhli, Turki Al-Otaibi, Osaid Al Meanazel, Md Khalid Anwer, Mohammed Muqtader Ahmed, Saad M. Alshahrani, Abdullah Alshetaili, Mohammed F. Aldawsari, Ahmad S. Alalaiwe, Ahmed Z. Alanazi, Mohammed A. Zahrani, Niyaz Ahmad
Summary: The study successfully developed a novel self-nanoemulsifying drug delivery system (SNEDDS) to improve the solubility, in vitro release, permeation and anticancer activity of brigatinib. The optimized SNEDDS showed a 205-fold enhancement in brigatinib saturation solubility, improved ex-vivo permeation and cytotoxic activity against cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chia-Chih Liao, Huang-Ping Yu, Shih-Chun Yang, Ahmed Alalaiwe, You-Shan Dai, Fu-Chao Liu, Jia-You Fang
Summary: The developed NLCs exhibit dual effects of anti-MRSA bacteremia, significantly mitigating organ damage through a combination of antibacterial and anti-inflammatory effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
G. R. Nirmal, Zih-Chan Lin, Ming-Jun Tsai, Shih-Chun Yang, Ahmed Alalaiwe, Jia-You Fang
Summary: This study designed a nanocomplex capable of treating psoriasis through hyperthermia induced by near-infrared irradiation. The nanocomplexes were shown to specifically induce keratinocyte apoptosis, inhibit the progression of lesions, and recover overexpressed cytokines in an in vivo psoriasiform murine model. The photothermal nanosystems show promise as a new therapeutic approach against psoriasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Md Khalid Anwer, Muzaffar Iqbal, Mohammed F. Aldawsari, Ahmed Alalaiwe, Mohammed Muqtader Ahmed, Magdy M. Muharram, Essam Ezzeldin, Mohamed A. Mahmoud, Faisal Imam, Raisuddin Ali
Summary: In this study, a novel self-nanoemulsifying drug delivery system (SNEDDS) was developed to improve the oral bioavailability of delafloxacin (DLF). The optimized DLF loaded SNEDDS demonstrated superior antimicrobial activity and significantly improved oral bioavailability of DLF compared to pure DLF suspension, suggesting its potential as a carrier in enhancing bioavailability and therapeutic efficacy of DLF.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mohammed Muqtader Ahmed, Farhat Fatima, Md Khalid Anwer, Elmutasim Osman Ibnouf, Mohd Abul Kalam, Aws Alshamsan, Mohammed F. Aldawsari, Ahmed Alalaiwe, Mohammad Javed Ansari
Summary: In this study, four formulations of butenafine loaded nanosponges were fabricated and one formulation was optimized based on particle characteristics and drug encapsulation. Physicochemical evaluations confirmed polymer-drug compatibility, drug encapsulation, and non-crystalline state of the drug in spherical nanosponges. The optimized nanosponge formulation showed promising antifungal activity against pathogenic fungal strains.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Ahmed Al Saqr, El-Sayed Khafagy, Ahmed Alalaiwe, Mohammed E. Aldawsari, Saad M. Alshahrani, Md Khalid Anwer, Salman Khan, Amr S. Abu Lila, Hany H. Arab, Wael A. H. Hegazy
Summary: This study demonstrates the efficient synthesis of gold nanoparticles (GNPs) using peel extracts of Benincasa hispida, which exhibited significant antibacterial and anticancer activities. The biosynthesized GNPs showed spherical shape with an average particle size of 22.18 +/- 2 nm, and exerted cytotoxic effects on human cervical cancer cells while sparing normal cells. Such cytotoxicity was attributed to the increased production of reactive oxygen species (ROS). Overall, B. hispida peel extracts can be a natural source of antimicrobial and anticancer agents through the synthesis of GNPs.
Article
Medicine, Research & Experimental
Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang
Summary: This study evaluated the topical application of rhubarb anthraquinone aglycones for psoriasis treatment. The anti-inflammatory effects of five anthraquinones were compared in cell-based studies, showing reduction in cytokines and inhibition of MAPK and NF-kappa B signaling. Both rhein and chrysophanol were effective in improving psoriasis symptoms in a mouse model, demonstrating multifunctional inhibition of psoriasiform inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Polymer Science
Mohammed Muqtader Ahmed, Md. Khalid Anwer, Farhat Fatima, Mohammed F. Aldawsari, Ahmed Alalaiwe, Amer S. Alali, Abdulrahman I. Alharthi, Mohd Abul Kalam
Summary: In this study, lipid-polymer hybrid nanoparticles (LPHNPs) were fabricated using lipoid-90H and chitosan, and loaded with the anticancer drug sunitinib malate (SM). The optimized formulation, SLPN4, showed suitable size, stability, and drug release rate. It exhibited potent cytotoxicity against MCF-7 breast cancer cells and could be a promising therapy option for breast cancer.
Article
Pharmacology & Pharmacy
Mohamed H. Fayed, Ahmed Alalaiwe, Ziyad S. Almalki, Doaa A. Helal
Summary: In this study, a quality-by-design (QbD) approach using design-of-experiment (DoE) was implemented to optimize the key process variables in the green fluidized bed granulation (GFBG) process. The results showed that by optimizing the water amount and spray rate, the GFBG process can enhance the disintegration and dissolution of tablets containing a poorly water-soluble drug.
Article
Engineering, Chemical
Md Khalid Anwer, Essam A. Ali, Muzaffar Iqbal, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Ahmed Al Saqr, Ahmed Alalaiwe, Gamal A. Soliman
Summary: In this study, OLP-loaded PLGA nanoparticles and OLP-CS-PLGA nanoparticles were successfully prepared to improve the dissolution rate and bioavailability of Olaparib. The results showed that OLP-CS-PLGA nanoparticles could be an effective approach for enhancing the bioavailability of Olaparib.
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Article
Materials Science, Multidisciplinary
Mohammad Javed Ansari, Najeeb Ur Rehman, Elmoatasim Ibnouf, Ahmed Alalaiwe, Majid Ahmad Ganaie, Ameeduzzafar Zafar
Summary: This research article presents the development, characterization, stability, antimicrobial activity, antispasmodic activity, and antidiarrheal activity of silver nanoparticles synthesized and stabilized by a polymeric coating of gum tragacanth solution. The study found that the silver nanoparticles exhibited good stability and significant antimicrobial, antispasmodic, and antidiarrheal activities.
Article
Pharmacology & Pharmacy
Ahmed Alalaiwe, Mohammad A. Alsenaidy, Ziyad S. Almalki, Mohamed H. Fayed
Summary: This study developed and optimized sildenafil orodispersible mini-tablets (ODMTs) for the treatment of pediatric pulmonary hypertension. Microcrystalline cellulose and partially pre-gelatinized starch were found to significantly influence the quality attributes of sildenafil ODMTs. By optimizing the formulation, the study achieved the optimal sildenafil ODMTs that meet the USP acceptance criteria.
Article
Polymer Science
El-Sayed Khafagy, Amr S. Abu Lila, Nahed Mohamed Sallam, Rania Abdel-Basset Sanad, Mahgoub Mohamed Ahmed, Mamdouh Mostafa Ghorab, Hadil Faris Alotaibi, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Ahmed Al Saqr, Shadeed Gad
Summary: This study aimed to investigate the efficacy of bilosomes-based mucoadhesive carvedilol nanosponge for enhancing the oral bioavailability of carvedilol. The bilosomes were prepared, optimized and characterized, and then incorporated into a composite mixture to obtain buccal nanosponge enriched with bilosomes. The optimized bilosome formula showed minimum vesicle size, maximum entrapment, and highest cumulative in vitro release, exhibiting sustained drug release for up to 24 h. In vivo assessment in rats indicated that the carvedilol-loaded nanosponge efficiently enhanced blood pressure, decreased oxidative stress, improved lipid profile, and exhibited a potent cardio-protective effect.
Article
Polymer Science
Vaibhav Gupta, Sradhanjali Mohapatra, Harshita Mishra, Uzma Farooq, Keshav Kumar, Mohammad Javed Ansari, Mohammed F. Aldawsari, Ahmed S. Alalaiwe, Mohd Aamir Mirza, Zeenat Iqbal
Summary: Nanotechnology has the potential to improve cosmetic formulations and enhance their effectiveness. The use of nanomaterials in cosmetics has been found to overcome certain limitations and improve consumer satisfaction. However, concerns have been raised regarding the potential health hazards of nanocosmetics due to their ability to penetrate the skin. This article provides an overview of nanotechnology-based approaches in cosmetics, discusses the benefits and risks associated with nanocosmetics, and highlights the regulatory status of cosmeceuticals in different regions.