Article
Microbiology
Isabel Guthridge, Simon Smith, Matthew Law, Enzo Binotto, Josh Hanson
Summary: Lincosamides, particularly when used as a predominant therapy, show potential efficacy in the treatment of MRSA bacteremia, especially in young, clinically stable patients with few comorbidities. Patients receiving lincosamide-predominant therapy had lower in-hospital mortality and a lower incidence of renal complications compared to those receiving an alternative regimen. Prospective studies are needed to further define the optimal role of lincosamides in the treatment of MRSA bacteremia.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Hematology
Oscar Negron, Miranda Weggeman, Jos Grimbergen, Emily G. Clark, Sara Abrahams, Woosuk S. Hur, Jaap Koopman, Matthew J. Flick
Summary: This study found that changing the ratio of naturally occurring fibrinogen variants in blood could offer significant therapeutic potential against bacterial infection and potentially other diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Matthew P. Cheng, Alexander Lawandi, Guillaume Butler-Laporte, Samuel De L'Etoile-Morel, Katryn Paquette, Todd C. Lee
Summary: The study aimed to determine the efficacy of synergistic treatment with daptomycin when given with either cefazolin or cloxacillin for the treatment of MSSA BSI. Results showed that adjunctive daptomycin therapy did not shorten the duration of bacteremia when added to standard-of-care treatment for MSSA BSIs, and should not be routinely considered.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Tohid Piri-Gharaghie, Neda Jegargoshe-Shirin, Sara Saremi-Nouri, Seyed-Hossein Khademhosseini, Eskandar Hoseinnezhad-Lazarjani, Aezam Mousavi, Hamidreza Kabiri, Negin Rajaei, Anali Riahi, Ali Farhadi-Biregani, Sadegh Fatehi-Ghahfarokhi
Summary: This study aims to assess the antibacterial and anti-biofilm properties of Niosome-encapsulated Imipenem. The experiment discovered that Niosome-encapsulated Imipenem can effectively reduce the methicillin-resistant Staphylococcus epidermidis' resistance to antibiotics, enhance its anti-biofilm and antibiotic activity, and has the potential to be a new strategy for drug delivery.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Jeong Eun Lee, Shinwon Lee, Sohee Park, Soon O. Lee, Sun H. Lee
Summary: This study found that dysfunctional accessory gene regulator (agr) is associated with higher mortality in invasive methicillin-resistant Staphylococcus aureus infections. However, the association between agr dysfunction and mortality in methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B) was not significant. The functionality of agr in causative organisms may impact patients' outcomes in MSSA-B with moderate severity.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Robert Strengen Bigseth, Hakon Sandholdt, Andreas Petersen, Christian Ostergaard, Thomas Benfield, Louise Thorlacius-Ussing
Summary: This multicenter retrospective study evaluated the effect of empirical antimicrobial therapy on the clinical outcome of methicillin-susceptible Staphylococcus aureus bacteremia (MS-SAB). The study found no significant difference in mortality or relapse between patients treated with piperacillin-tazobactam or cefuroxime as empirical therapy for MS-SAB.
MICROBIOLOGY SPECTRUM
(2022)
Article
Nanoscience & Nanotechnology
Maricely Ramirez-Hernandez, Javiera Norambuena, Hongnan Hu, Belvin Thomas, Chaoyun Tang, Jeffrey M. Boyd, Tewodros Asefa
Summary: The urgent need for materials that can more efficiently deliver antimicrobial agents has arisen due to the increase in microbial resistance to traditional antibiotics. This study presents the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials loaded with rafoxanide and anchored Cu(II) ions, which exhibit enhanced antimicrobial efficacy against pathogenic Staphylococcus aureus. The structurally characterized nanomaterials demonstrate 10 times the bactericidal action compared to nanomaterials loaded with rafoxanide only, and the synthetic sequence used in the production significantly impacts their bactericidal efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Louise Thorlacius-Ussing, Hakon Sandholdt, Jette Nissen, Jon Rasmussen, Robert Skov, Niels Frimodt-Moller, Jenny Dahl Knudsen, Christian Ostergaard, Thomas Benfield
Summary: This study found that in low-risk methicillin-susceptible Staphylococcus aureus bacteremia patients, shorter courses of antimicrobial therapy yielded similar clinical outcomes as longer courses of therapy, with no significant differences in 90-day mortality observed in both individual cohort and pooled cohort analysis.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Daniel J. Minter, Ayesha Appa, Henry F. Chambers, Sarah B. Doernberg
Summary: This review aims to provide a comprehensive overview of the evaluation and management of Staphylococcus aureus bacteremia, with a special focus on areas where the highest level of evidence is lacking to inform best practices.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Pharmacology & Pharmacy
Daniel B. Chastain, Kelly L. Covert, Patrick J. Tu, Steven McDougal, Bryan P. White, David Cluck
Summary: This article aims to compare the efficacy of antimicrobial therapies used in the management of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. A literature search was conducted using the PubMed database, resulting in the review of 78 articles. Currently, there is limited guidance on the optimal management of patients with persistent MSSA bacteremia, and this narrative review provides clinicians with reliable data to assist in selecting the best antimicrobial regimen for this clinical conundrum. Based on the synthesis of data, modification of antimicrobial therapy, along with source control and infectious diseases consultation, may be necessary to sterilize blood cultures in patients with persistent MSSA bacteremia.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Microbiology
Sara Grillo, Mireia Puig-Asensio, Marin L. Schweizer, Guillermo Cuervo, Isabel Oriol, Miquel Pujol, Jordi Carratala
Summary: This meta-analysis found that combination therapy did not significantly decrease mortality in patients with MSSA bacteremia, but increased the risk of adverse events. However, adjunctive rifampicin may reduce 90-day mortality in patients with deep-seated infections. Combination therapy was associated with a decreased risk of relapse, but this benefit was not maintained in the pooled randomized controlled trials.
Article
Microbiology
Ahmad Mourad, Thomas L. Holland, Nicholas A. Turner
Summary: This commentary reflects on the impact of clopidogrel use on clinical outcomes in patients with Staphylococcus aureus bacteremia, as analyzed in a recent study.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Mohammed H. Alqarni, Ahmed Foudah, Aftab Alam, Mohammad A. Salkini, Magdy M. Muharram, Nikolaos E. Labrou, Pinki Rawat
Summary: Bacterial infections caused by antibiotic-resistant pathogens are a significant public health problem. Develop innovative strategies to effectively eliminate antibiotic-resistant microorganisms are urgently needed. Coumarin has shown significant effectiveness against MRSA and can be used as an alternative treatment. Nanoparticle-based targeted therapies can effectively treat MRSA infections.
BIOENGINEERING-BASEL
(2022)
Article
Food Science & Technology
Fatimah Alhurayri, Edith Porter, Rachid Douglas-Louis, Emi Minejima, Juliane Bubeck Wardenburg, Annie Wong-Beringer
Summary: In patients with Staphylococcus aureus bacteremia, the in vitro Hla activity of MRSA strains is significantly associated with an increased risk of thrombocytopenia and death, while the Hla activity of MSSA strains does not differ significantly between patient groups. These findings support future studies to evaluate the feasibility of bedside phenotyping and therapeutic targeting.
Article
Cell Biology
Chia-Chih Liao, Huang-Ping Yu, An-Hsun Chou, Hung-Chen Lee, Li-Min Hu, Fu-Chao Liu
Summary: Gastrodin can alleviate liver injury caused by acetaminophen, exerting its effects by inhibiting inflammation and activating antioxidant response.
Article
Polymer Science
Mohammed Muqtader Ahmed, Md. Khalid Anwer, Farhat Fatima, Mohammed F. Aldawsari, Ahmed Alalaiwe, Amer S. Alali, Abdulrahman I. Alharthi, Mohd Abul Kalam
Summary: In this study, lipid-polymer hybrid nanoparticles (LPHNPs) were fabricated using lipoid-90H and chitosan, and loaded with the anticancer drug sunitinib malate (SM). The optimized formulation, SLPN4, showed suitable size, stability, and drug release rate. It exhibited potent cytotoxicity against MCF-7 breast cancer cells and could be a promising therapy option for breast cancer.
Article
Pharmacology & Pharmacy
Mohamed H. Fayed, Ahmed Alalaiwe, Ziyad S. Almalki, Doaa A. Helal
Summary: In this study, a quality-by-design (QbD) approach using design-of-experiment (DoE) was implemented to optimize the key process variables in the green fluidized bed granulation (GFBG) process. The results showed that by optimizing the water amount and spray rate, the GFBG process can enhance the disintegration and dissolution of tablets containing a poorly water-soluble drug.
Article
Engineering, Chemical
Md Khalid Anwer, Essam A. Ali, Muzaffar Iqbal, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Ahmed Al Saqr, Ahmed Alalaiwe, Gamal A. Soliman
Summary: In this study, OLP-loaded PLGA nanoparticles and OLP-CS-PLGA nanoparticles were successfully prepared to improve the dissolution rate and bioavailability of Olaparib. The results showed that OLP-CS-PLGA nanoparticles could be an effective approach for enhancing the bioavailability of Olaparib.
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Article
Biology
Fu-Chao Liu, Chia-Chih Liao, Hung-Chen Lee, An-Hsun Chou, Y. Huang-Ping
Summary: Corilagin has been found to have protective effects on acute lung injury by reducing pro-inflammatory mediators and oxidative stress. It shows potential as a therapeutic agent for the treatment of this life-threatening respiratory disease.
Article
Materials Science, Multidisciplinary
Mohammad Javed Ansari, Najeeb Ur Rehman, Elmoatasim Ibnouf, Ahmed Alalaiwe, Majid Ahmad Ganaie, Ameeduzzafar Zafar
Summary: This research article presents the development, characterization, stability, antimicrobial activity, antispasmodic activity, and antidiarrheal activity of silver nanoparticles synthesized and stabilized by a polymeric coating of gum tragacanth solution. The study found that the silver nanoparticles exhibited good stability and significant antimicrobial, antispasmodic, and antidiarrheal activities.
Article
Medicine, General & Internal
Yun-Hui Teng, Fu-Chao Liu, Shang-Yu Huang, Chang-Fu Kuo, Huang-Ping Yu
Summary: This study estimated the incidence and mortality rates of different histological subtypes of ovarian cancer in Taiwan by analyzing the national databases. The findings showed an increasing incidence rate but decreasing overall mortality rate of ovarian cancer during the study period. Ovarian serous carcinoma was the most common histological subtype in Taiwan.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Huan-Tang Lin, Mei-Ling Cheng, Chi-Jen Lo, Gigin Lin, Fu-Chao Liu
Summary: The study identifies altered metabolic markers in the cerebrospinal fluid and plasma of diabetic patients with DKD, which could be valuable for monitoring the progression of DKD.
Article
Pharmacology & Pharmacy
Ahmed Alalaiwe, Mohammad A. Alsenaidy, Ziyad S. Almalki, Mohamed H. Fayed
Summary: This study developed and optimized sildenafil orodispersible mini-tablets (ODMTs) for the treatment of pediatric pulmonary hypertension. Microcrystalline cellulose and partially pre-gelatinized starch were found to significantly influence the quality attributes of sildenafil ODMTs. By optimizing the formulation, the study achieved the optimal sildenafil ODMTs that meet the USP acceptance criteria.
Article
Materials Science, Biomaterials
G. R. Nirmal, Zih-Chan Lin, Chih-Hung Lin, Calvin T. Sung, Chia-Chih Liao, Jia-You Fang
Summary: The study developed phototheranostic nanocarriers for the treatment of psoriasis. These nanocarriers can generate hyperthermia and reactive oxygen species upon near-infrared illumination, effectively inhibiting keratinocyte hyperproliferation. The results suggest that the nanocarriers have potential for noninvasive topical administration in psoriasis management.
BIOMATERIALS SCIENCE
(2022)
Article
Polymer Science
El-Sayed Khafagy, Amr S. Abu Lila, Nahed Mohamed Sallam, Rania Abdel-Basset Sanad, Mahgoub Mohamed Ahmed, Mamdouh Mostafa Ghorab, Hadil Faris Alotaibi, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Ahmed Al Saqr, Shadeed Gad
Summary: This study aimed to investigate the efficacy of bilosomes-based mucoadhesive carvedilol nanosponge for enhancing the oral bioavailability of carvedilol. The bilosomes were prepared, optimized and characterized, and then incorporated into a composite mixture to obtain buccal nanosponge enriched with bilosomes. The optimized bilosome formula showed minimum vesicle size, maximum entrapment, and highest cumulative in vitro release, exhibiting sustained drug release for up to 24 h. In vivo assessment in rats indicated that the carvedilol-loaded nanosponge efficiently enhanced blood pressure, decreased oxidative stress, improved lipid profile, and exhibited a potent cardio-protective effect.
Article
Polymer Science
Vaibhav Gupta, Sradhanjali Mohapatra, Harshita Mishra, Uzma Farooq, Keshav Kumar, Mohammad Javed Ansari, Mohammed F. Aldawsari, Ahmed S. Alalaiwe, Mohd Aamir Mirza, Zeenat Iqbal
Summary: Nanotechnology has the potential to improve cosmetic formulations and enhance their effectiveness. The use of nanomaterials in cosmetics has been found to overcome certain limitations and improve consumer satisfaction. However, concerns have been raised regarding the potential health hazards of nanocosmetics due to their ability to penetrate the skin. This article provides an overview of nanotechnology-based approaches in cosmetics, discusses the benefits and risks associated with nanocosmetics, and highlights the regulatory status of cosmeceuticals in different regions.