NPC 1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP 46A1 activation

Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability

(2019) Oscar Vivas et al.   Cell Reports

Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses

(2016) G. Aleph Prieto et al.   JOURNAL OF NEUROSCIENCE

Extensive phosphorylation of AMPA receptors in neurons

(2016) Graham H. Diering et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses

(2016) Thomas Kirkegaard et al.   Science Translational Medicine

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

(2015) X. Du et al.   BIOCHEMICAL JOURNAL

Glutamate Signaling in Synaptogenesis and NMDA Receptors as Potential Therapeutic Targets for Psychiatric Disorders

(2015) Y. Ohgi et al.   CURRENT MOLECULAR MEDICINE

Comparative Safety and Neuropsychiatric Adverse Events Associated With Efavirenz Use in First-Line Antiretroviral Therapy

(2015) Nathan Ford et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery

(2015) Anna Brachet et al.   JOURNAL OF CELL BIOLOGY

The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: Central mediators of pathophysiology and antidepressant activity?

(2015) Florian Freudenberg et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease

(2015) Charles H. Vite et al.   Science Translational Medicine

Endoplasmic Reticulum-associated Degradation of Niemann-Pick C1

(2014) Naoe Nakasone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression

(2014) K. L. Arendt et al.   JOURNAL OF CELL SCIENCE

Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin

(2014) Jean E. Vance et al.   JOURNAL OF LIPID RESEARCH

Relevance of neuronal and glial NPC1 for synaptic input to cerebellar Purkinje cells

(2014) Isabelle Buard et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Lipid dynamics at dendritic spines

(2014) Carlos Gerardo Dotti et al.   Frontiers in Neuroanatomy

Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1: Implication for the Existence of Second Sterol-Binding Site

(2013) Kenji Ohgane et al.   CHEMISTRY & BIOLOGY

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of Niemann–Pick Type C Disease by Histone Deacetylase Inhibitors

(2013) Paul Helquist et al.   Neurotherapeutics

Cholesterol loss during glutamate-mediated excitotoxicity

(2012) Alejandro O Sodero et al.   EMBO JOURNAL

A Role for Sphingomyelin-Rich Lipid Domains in the Accumulation of Phosphatidylinositol-4,5-Bisphosphate to the Cleavage Furrow during Cytokinesis

(2012) M. Abe et al.   MOLECULAR AND CELLULAR BIOLOGY

Endosomal/Lysosomal Processing of Gangliosides Affects Neuronal Cholesterol Sequestration in Niemann-Pick Disease Type C

(2011) Sharon Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

A novel mouse model of Niemann–Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations

(2011) Robert A. Maue et al.   HUMAN MOLECULAR GENETICS

An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease

(2011) Andrew B. Munkacsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

(2011) A. Aqul et al.   JOURNAL OF NEUROSCIENCE

Cerebellar Long-term Depression is Deficient in Niemann–Pick Type C Disease Mice

(2010) Cheng-Long Sun et al.   CEREBELLUM

Opioid-Induced Long-Term Potentiation in the Spinal Cord Is a Presynaptic Event

(2010) H.-Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro

(2010) Alejandro O. Sodero et al.   NEUROBIOLOGY OF AGING

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

(2009) Benny Liu et al.   JOURNAL OF LIPID RESEARCH

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

(2009) B. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Niemann-Pick Type C1 I1061T Mutant Encodes a Functional Protein That Is Selected for Endoplasmic Reticulum-associated Degradation Due to Protein Misfolding

(2008) Mark E. Gelsthorpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY