Article
Biochemistry & Molecular Biology
Jingjing He, Fangyan Chen, Sitong Wan, Yongting Luo, Junjie Luo, Shuli He, Daizhan Zhou, Peng An, Ping Zeng
Summary: Antioxidant minerals such as zinc, copper and selenium have important roles in maintaining redox balance in the body. This study aimed to investigate the relationship between these minerals and type 2 diabetes mellitus (T2DM) in Chinese populations. The results showed a negative association between serum zinc and copper concentrations and T2DM, while no association was found for serum selenium. Adequate intake of antioxidant minerals is emphasized for T2DM prevention in the Chinese population.
Review
Nutrition & Dietetics
Khalid M. Sumaily
Summary: Trace elements are chemical elements with very low concentrations. Copper, selenium, zinc, iron, and magnesium are among the essential micronutrients that play important roles in human health. Different trace elements have been found to play substantial roles in viral infections and the pathogenesis of liver diseases and diabetes.
Article
Environmental Sciences
Celia Rodriguez-Perez, Celia Gomez-Pena, Francisco M. Perez-Carrascosa, Petra Vrhovnik, Ruth Echeverria, Inmaculada Salcedo-Bellido, Vicente Mustieles, Fiket Zeljka, Juan Pedro Arrebola
Summary: This study revealed that adipose tissue concentrations of chromium, iron, and copper were associated with the incidence of T2DM over a 16-year follow-up period. Additionally, vanadium and zinc concentrations were positively correlated with pancreatic cell function, while selenium showed an inverse association. These findings suggest that certain trace elements in adipose tissue may play a role in the development of T2DM and have potential implications for identifying individuals at risk.
ENVIRONMENTAL POLLUTION
(2021)
Review
Medicine, General & Internal
Behnam Ghorbani Nejad, Tahereh Raeisi, Parisa Janmohammadi, Fatemeh Mehravar, Mahtab Zarei, Azadeh Dehghani, Niki Bahrampour, Mohammad Hosein Darijani, Fatemeh Ahmadipour, Mohammad Mohajeri, Shahab Alizadeh
Summary: This study found that mercury levels were higher in type 2 diabetes patients compared to non-diabetics, but there was no significant association between mercury exposure and the overall risk of type 2 diabetes. However, higher mercury exposure may reduce the risk of type 2 diabetes in men.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Kiran Kumar Pvsn, Sojit Tomo, Purvi Purohit, Shrimanjunath Sankanagoudar, Jayakaran Charan, Abhishek Purohit, Vijaylakshami Nag, Pradeep Bhatia, Kuldeep Singh, Naveen Dutt, Mahendra Kumar Garg, Praveen Sharma, Sanjeev Misra, Dharamveer Yadav
Summary: Deficiencies of trace elements and infectious diseases exhibit complex interactions. This study found that serum zinc and copper levels were significantly decreased in COVID-19 patients, while serum magnesium levels were slightly decreased. Serum copper/zinc ratio along with patient age can serve as reliable markers for COVID-19 course and survival odds.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
D. Hamoutene, K. Hua, A. Lacoursiere-Roussel, F. Page, S. M. Baillie, L. Brager, F. Salvo, T. Coyle, K. Chernoff, M. Black, D. Wong, E. Nelson, T. Bungay, D. Gaspard, E. Ryall, C. W. Mckindsey, T. F. Sutherland
Summary: The study conducted sediment sampling at finfish farms in three distinct Canadian regions and identified several trace elements, including Cu, Zn, Cd, Mo and U, as indicators of finfish aquaculture organic enrichment. Multivariate analyses showed a consistent clustering of these tracers with sediment organic matter and/or total dissolved sulfides concentrations. Organic matter content was found to be a predictor of the concentrations of these elements according to decision tree analyses. Distance from cages did not significantly impact the differences among sampling points.
MARINE POLLUTION BULLETIN
(2021)
Article
Nutrition & Dietetics
Guifang Deng, Hengying Chen, Yao Liu, Yingyu Zhou, Xiaoping Lin, Yuanhuan Wei, Ruifang Sun, Zheqing Zhang, Zhenhe Huang
Summary: This study found that exposure to serum zinc, copper, iron, and calcium during early pregnancy is positively associated with the risk of GDM. A mixture of elements, particularly cadmium, zinc, and copper, may promote the development of GDM.
FRONTIERS IN NUTRITION
(2023)
Article
Engineering, Environmental
Duo Zhang, Xiao Chen, Ke Huang, Quanzhi Zheng, Ying Fu, Jiaojiao Ma, Xiaohu Ren, Benhong Xu, Peiyi Liu, Jianjun Liu, Shaoyou Lu
Summary: This large-scale cross-sectional study investigated the relationship between urinary metal mixtures and type 2 diabetes mellitus (T2DM) among Chinese adults. The study found that exposure to toxic metals (Pb, Cd, Sb) and excessive intake of Se and Zn were associated with an increased risk of developing T2DM. The study also revealed that shortened telomere length mediated a significant portion of the positive effect of metal exposure on T2DM, primarily through toxic metal exposure and excessive Se intake. Further research is needed to determine the optimal dosage of Zn for T2DM patients at different stages.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Nutrition & Dietetics
Huixian Zeng, Yuanyuan Hu, Yaosheng Luo, Yanshi Ye, Cheng Song, Genfeng Yu, Zhi Chen, Siyang Liu, Yongqian Liang, Lingling Liu, Heng Wan, Jie Shen
Summary: The present study aimed to determine the relationship between selected trace elements and thyroid nodules (TNs) in the iodine-adequate area of Guangdong, China. The results showed that serum copper, magnesium, and zinc levels were associated with the presence of TNs among healthy subjects.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Maria Cabral, Olga Kuxhaus, Fabian Eichelmann, Johannes F. Kopp, Wiebke Alker, Julian Hackler, Anna P. Kipp, Tanja Schwerdtle, Hajo Haase, Lutz Schomburg, Matthias B. Schulze
Summary: Different trace elements such as manganese, iron, copper, zinc, iodine, and selenium were associated with the risk of developing type 2 diabetes, cardiovascular disease, and colorectal cancer. The contrasting associations found for selenium with diabetes and cancer point towards differential disease-related pathways.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Endocrinology & Metabolism
Monika Rychert-Stos, Mieczyslaw Walczak, Anita Horodnicka-Jozwa, Hanna Romanowska, Daria Katuszonek, Krystyna Wyka, Hanna Chojnacka, Wojciech Marciniak, Elzbieta Petriczko
Summary: This study assessed the concentrations of trace elements in children with newly diagnosed type 1 diabetes mellitus (DM1) and found increased levels of selenium and arsenic, elevated copper levels at diagnosis, and no significant differences in zinc concentrations. Trace elements in the environment, especially selenium, may increase the incidence of DM1, but further research is needed to confirm this association.
NEUROENDOCRINOLOGY LETTERS
(2022)
Article
Medicine, General & Internal
Jianan Feng, Heyuan Wang, Zhe Jing, Yue Wang, Wanning Wang, Yanfang Jiang, Weixia Sun
Summary: Zinc and magnesium are essential trace elements in humans, and their deficiency may be associated with inflammation and oxidative stress. This study found that serum concentrations of zinc and magnesium were significantly lower in patients with T2DM and DN, while levels of IL-6 and IL-8 increased with the progression of renal functional damage associated with DN. Additionally, serum zinc concentration was independently protective against DN in patients with T2DM, suggesting a potential role of hypozincemia in aggravating inflammation and renal damage.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Felix Javier Jimenez-Jimenez, Pedro Ayuso, Hortensia Alonso-Navarro, Marisol Calleja, Monica Diez-Fairen, Ignacio Alvarez, Pau Pastor, Jose Francisco Plaza-Nieto, Santiago Navarro-Munoz, Laura Turpin-Fenoll, Jorge Millan-Pascual, Marta Recio-Bermejo, Rafael Garcia-Ruiz, Esteban Garcia-Albea, Jose A. G. Agundez, Elena Garcia-Martin
Summary: Increased brain and serum zinc levels were found in patients with idiopathic restless legs syndrome (iRLS) compared to controls, suggesting the involvement of zinc in the pathogenesis of the disease. However, the levels of other trace elements were similar between RLS patients and controls. This study revealed that RLS patients in a Spanish Caucasian population have significantly higher serum concentrations of copper, magnesium, selenium, and calcium compared to controls, with no major correlation to age at onset, severity, family history or drug response.
Article
Clinical Neurology
Dong Huang, Shuming Zhong, Hong Yan, Shunkai Lai, Meifong Lam, Yanbin Jia
Summary: This study found that decreased serum zinc levels may increase susceptibility to suicidal ideation, but there is no significant relationship between serum copper or selenium levels and suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Mugisha Kyaruzi, Taner Iyigun, Vesile Ornek Diker, Bahar Ozturk Kurt, Zeynep Kahraman, Burak Onan
Summary: This study evaluated the levels of trace elements in adult patients undergoing coronary artery bypass grafting and found that a decrease in these levels was associated with an increased risk of postoperative complications such as atrial fibrillation, kidney injury, liver injury, and wound infection.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Article
Microbiology
Maryam Dadar, Saeed Alamian, Hanka Brangsch, Mohamed Elbadawy, Ahmed R. Elkharsawi, Heinrich Neubauer, Gamal Wareth
Summary: This study investigated antimicrobial resistance (AMR) and virulence-associated factors in Brucella isolates from humans and animals in Iran. B. melitensis was the most common species, while B. abortus was isolated from only one human case. The isolates showed intermediate or resistant phenotype patterns for certain antibiotics. Whole genome sequencing (WGS) identified several virulence-associated genes, but failed to determine classical AMR genes. The findings suggest a need for further investigation into the proteomic and transcriptomic levels of phenotypic resistance mechanisms.
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Review
Chemistry, Medicinal
Amin Gasmi, Pavan Kumar Mujawdiya, Amine Nehaoua, Mariia Shanaida, Yuliya Semenova, Salva Piscopo, Alain Menzel, Volodymyr Voloshyn, Olena Voloshyn, Volodymyr Shanaida, Geir Bjorklund
Summary: The obesity pandemic is a pressing public health concern, with a projected increase in the number of obese or overweight individuals by 2025. Current strategies for treating obesity focus on patient-centered approaches including diet, behavior, medication, and surgery. However, there is a need for novel and more effective pharmaceutical drugs to assist with lifestyle modifications and better manage obesity.
Review
Infectious Diseases
Yernar Amangelsin, Yuliya Semenova, Maryam Dadar, Mohamad Aljofan, Geir Bjorklund
Summary: Tetracycline, a widely used antibiotic, has become a serious threat to the environment due to overuse and weak degradation ability. It accumulates in the food chain, causing toxicity to microbial communities, promoting antibiotic resistance, and disrupting human intestinal flora.
Article
Public, Environmental & Occupational Health
Maryam Dadar, Hanka Brangsch, Saeed Alamian, Heinrich Neubauer, Gamal Wareth
Summary: Brucellosis is a common zoonotic disease in the Middle East, causing economic losses to the livestock industry and posing a great public health concern. This study analyzed the genetic diversity and distribution of Brucella spp. in Iran using whole genome sequencing technology. The results revealed a close relationship between Iranian strains and strains from neighboring and Middle East countries, emphasizing the importance of brucellosis control measures in Iran.
Article
Multidisciplinary Sciences
Faranak Abnaroodheleh, Anahita Emadi, Shojaat Dashtipour, Tariq Jamil, Amin Mousavi Khaneghah, Maryam Dadar
Summary: A cross-sectional study in industrial dairy cattle farms in Iran revealed the presence of Brucella spp., including Brucella abortus and Brucella melitensis, in the Alborz and Tehran provinces. The seroprevalence of brucellosis in these farms was significant, and the shedding of Brucella in the milk of seropositive cows posed a serious risk of transmission to humans. Therefore, comprehensive bacteriological and serological tests, including analysis of blood and milk samples, should be conducted in order to control the spread of the disease.
Article
Veterinary Sciences
Maryam Dadar, Akram Bahreinipour, Saeed Alamian, Ali Reza Yousefi, Karim Amiri, Faranak Abnaroodheleh
Summary: This study aimed to determine the prevalence of Brucella in buffalo milk samples in Iran using serological, molecular, and cultural analyses. The study found positive results for the presence of Brucella DNA in various provinces of Iran, with the AMOS PCR method showing significantly higher sensitivity compared to the milk ring test agglutination test and milk sample culture.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Health Policy & Services
Valeriy Zub, Yuliya Semenova, Oleksandr Tolstanov, Andrii Kotuza, Taras Gutor, Oksana Matsyura, Roman Lysiuk, Geir Bjorklund
Summary: This study assessed the challenges faced by oncologists in providing cancer care in Ukraine after the armed conflict. The findings showed that physicians in regions occupied by the Russian army experienced a significant decline in patient numbers, while most physicians were satisfied with the availability of medicines and equipment.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Neurosciences
Neluwa-Liyanage R. Indika, Udara D. Senarathne, Antonio Malvaso, Dhanushka Darshana, Susan C. Owens, Borhan Mansouri, Yuliya Semenova, Geir Bjorklund
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social interaction and communication deficits, along with repetitive and restricted patterns of activities, behavior, and interests. Heavy metal exposure, abnormal metabolism, and genetic susceptibility may play a role in the pathogenesis of ASD. Altered porphyrin metabolism in ASD may be associated with deficiencies in vitamins and minerals, and potential metabolic therapies such as supplementation with vitamins, minerals, cofactors, and antioxidants need to be explored in future research.
MOLECULAR NEUROBIOLOGY
(2023)