Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Oncology
Chen Yuan, Xuehong Zhang, Ana Babic, Vicente Morales-Oyarvide, Yin Zhang, Stephanie A. Smith-Warner, Kana Wu, Molin Wang, Brian M. Wolpin, Jeffrey A. Meyerhardt, Andrew T. Chan, Frank B. Hu, Charles S. Fuchs, Shuji Ogino, Edward L. Giovannucci, Kimmie Ng
Summary: Among patients with colorectal cancer, preexisting diabetes was associated with increased risk of long-term mortality, particularly from other malignancies and cardiovascular disease. The impact of diabetes on survival varied by sex, with women showing a modest increase in overall mortality in the first 5 years after cancer diagnosis. Beyond 5 years, both men and women with diabetes at diagnosis had substantially increased overall mortality.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Medicine, General & Internal
Behnam Ghorbani Nejad, Tahereh Raeisi, Parisa Janmohammadi, Fatemeh Mehravar, Mahtab Zarei, Azadeh Dehghani, Niki Bahrampour, Mohammad Hosein Darijani, Fatemeh Ahmadipour, Mohammad Mohajeri, Shahab Alizadeh
Summary: This study found that mercury levels were higher in type 2 diabetes patients compared to non-diabetics, but there was no significant association between mercury exposure and the overall risk of type 2 diabetes. However, higher mercury exposure may reduce the risk of type 2 diabetes in men.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Environmental Sciences
Celia Rodriguez-Perez, Celia Gomez-Pena, Francisco M. Perez-Carrascosa, Petra Vrhovnik, Ruth Echeverria, Inmaculada Salcedo-Bellido, Vicente Mustieles, Fiket Zeljka, Juan Pedro Arrebola
Summary: This study revealed that adipose tissue concentrations of chromium, iron, and copper were associated with the incidence of T2DM over a 16-year follow-up period. Additionally, vanadium and zinc concentrations were positively correlated with pancreatic cell function, while selenium showed an inverse association. These findings suggest that certain trace elements in adipose tissue may play a role in the development of T2DM and have potential implications for identifying individuals at risk.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Thorsten Otto, Joanna Diesing, Julia Borchert, Elke Heitmann, Nanette C. Schloot, Jeremie Lebrec, Dirk Mueller-Wieland, Dennis Haeckl
Summary: This study assessed the prevalence of type 2 diabetes mellitus (T2DM) in Germany, particularly in patients at risk for or with established cardiovascular disease (CVD), and their treatments. Using claims data, T2DM prevalence was estimated at 11.9%, higher in older patients. The majority of T2DM patients had at least one cardiovascular risk factor, and about half had established CVD. Early prevention of CVD in T2DM patients, especially in older individuals, is crucial. Furthermore, the use of insulin in older T2DM patients needs further evaluation.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill, Zuyun Liu
Summary: Using two widely used frailty indicators, this study found that frailty, even in the very early stage, was positively associated with the incidence risk of cardiovascular disease and type 2 diabetes mellitus among long-term cancer survivors.
Article
Endocrinology & Metabolism
Shuo Zhao, Ming-Li Liu, Bing Huang, Fu-Rong Zhao, Ying Li, Xue-Ting Cui, Rong Lin
Summary: This study found that elevated levels of short-chain acylcarnitine C2 were associated with increased risk of cardiovascular disease in patients with type 2 diabetes mellitus and this association remained significant even after adjusting for potential confounders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Raquel Sanabria-de la Torre, Cristina Garcia-Fontana, Sheila Gonzalez-Salvatierra, Francisco Andujar-Vera, Luis Martinez-Heredia, Beatriz Garcia-Fontana, Manuel Munoz-Torres
Summary: Vascular complications are the main cause of morbidity and mortality in patients with type 2 diabetes mellitus. The Wnt pathway plays an important role in the pathophysiology of the vascular wall and is altered in patients with type 2 diabetes. This review analyzes both microvascular and macrovascular complications and highlights the importance of exploring therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk of atherosclerotic disease. The study found that hypoglycemia induces a sustained inflammatory response at the cellular and protein level, which is present in both individuals with type 2 diabetes and control subjects.
Article
Nutrition & Dietetics
Hui-Ju Tsai, Wei-Chung Tsai, Wei-Chun Hung, Wei-Wen Hung, Chen-Chia Chang, Chia-Yen Dai, Yi-Chun Tsai
Summary: This study investigated the relationship between gut microbiota and subclinical cardiovascular disease (CVD) in patients with type 2 diabetes (T2D). The findings suggest that certain bacterial species associated with T2D, such as Bacteroidetes and Firmicutes, have correlations with cardiac structure and function. Changes in the gut microbiome, including the Firmicutes/Bacteroidetes ratio and levels of Bacteroides, may serve as potential markers for the development of subclinical CVD in T2D patients.
Article
Multidisciplinary Sciences
Eiichiro Kanda, Atsushi Suzuki, Masaki Makino, Hiroo Tsubota, Satomi Kanemata, Koichi Shirakawa, Toshitaka Yajima
Summary: A novel machine learning model was developed to predict the risk of developing CKD/HF in early-stage T2DM patients, showing good predictive performance in external validation. Early diagnosis and intervention based on ML models may improve the prognosis of high-risk patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Peder Af Geijerstam, Fredrik Janryd, Fredrik H. Nystrom
Summary: Cigarette smoking in patients with type 2 diabetes was not associated with an increased risk of major adverse cardiovascular events, but it was related to all-cause mortality. This raises the question of whether cardioprotective drugs in individuals with type 2 diabetes can mitigate the cardiovascular harm of smoking to some extent, despite not affecting other dire consequences of smoking.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Food Science & Technology
Meng Xia, Yujin Chen, Wei Li, Cheng Qian
Summary: We conducted a meta-analysis of 12 prospective cohort studies to investigate the relationship between lignan intake and the risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The results showed that higher lignan intake was associated with a decreased risk of CVD and T2DM, and the benefits were consistent across subgroups. In dose-response analysis, a higher intake of lignans was associated with a lower risk of CVD and T2DM.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Oncology
Alessandra Macciotta, Alberto Catalano, Maria Teresa Giraudo, Elisabete Weiderpass, Pietro Ferrari, Heinz Freisling, Sandra M. Colorado-Yohar, Carmen Santiuste, Pilar Amiano, Alicia K. Heath, Heather A. Ward, Sofia Christakoudi, Paolo Vineis, Deependra Singh, Salvatore Vaccarella, Matthias B. Schulze, Anouk E. Hiensch, Evelyn M. Monninkhof, Verena Katzke, Rudolf Kaaks, Rosario Tumino, Fulvio Lazzarato, Lorenzo Milani, Antonio Agudo, Christina C. Dahm, Laura Baglietto, Vittorio Perduca, Gianluca Severi, Sara Grioni, Salvatore Panico, Eva Ardanaz, Kristin B. Borch, Faith O. Benebo, Tonje Braaten, Maria-Jose Sanchez, Claudia Giachino, Carlotta Sacerdote, Fulvio Ricceri
Summary: This study examines the association between educational level and cancer incidence and finds that individuals with lower education have a higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, while having a lower risk of melanoma and breast cancer (in post-menopausal women). The study also suggests that specific lifestyle behaviors may explain part of this association.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Yahya Mahamat-Saleh, Marie Al-Rahmoun, Gianluca Severi, Reza Ghiasvand, Marit B. Veierod, Saverio Caini, Domenico Palli, Edoardo Botteri, Carlotta Sacerdote, Fulvio Ricceri, Marko Lukic, Maria J. Sanchez, Valeria Pala, Rosario Tumino, Paolo Chiodini, Pilar Amiano, Sandra Colorado-Yohar, Maria-Dolores Chirlaque, Eva Ardanaz, Catalina Bonet, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Kim Overvad, Christina C. Dahm, Christian S. Antoniussen, Anne Tjonneland, Cecilie Kyro, Bas Bueno-de-Mesquita, Jonas Manjer, Malin Jansson, Anders Esberg, Nagisa Mori, Pietro Ferrari, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Marina Kvaskoff
Summary: Experimental evidence suggests that alcohol is a risk factor for skin cancer, although epidemiological studies have produced inconsistent results. This study, conducted on participants from 10 European countries over a 15-year follow-up, found a positive association between alcohol intake and the risk of squamous-cell carcinoma, basal-cell carcinoma, and melanoma. The associations were stronger in men and more modest in women.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Wendy Yi-Ying Wu, Zahra Haider, Xiaoshuang Feng, Alicia K. Heath, Anne Tjonneland, Antonio Agudo, Giovanna Masala, Hilary A. Robbins, Maria-Jose Huerta, Marcela Guevara, Matthias B. Schulze, Miguel Rodriguez-Barranco, Paolo Vineis, Rosario Tumino, Rudolf Kaaks, Renee T. Fortner, Sabina Sieri, Salvatore Panico, Therese Haugdahl Nost, Torkjel M. Sandanger, Tonje Braaten, Mattias Johansson, Beatrice Melin, Mikael Johansson
Summary: The study evaluated the risk-discriminatory performance of the EarlyCDT-Lung test in ever-smokers and found that it is not effective in identifying high-risk individuals for lung cancer screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Julie A. Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Jose M. Huerta, Aurelio Barricarte, Pilar Amiano, Antonio Agudo, Anders Bjartell, Tanja Stocks, Elin Thysell, Maria Wennberg, Elisabete Weiderpass, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago
Summary: This study investigated the associations between dietary protein intake and prostate cancer risk and mortality. The results suggest that dairy protein and yogurt protein are positively associated with prostate cancer risk, while egg protein may be positively associated with prostate cancer mortality. However, considering the weak associations and many tests conducted, these results should be interpreted with caution.
Article
Medical Laboratory Technology
Cristina Razquin, Miguel Ruiz-Canela, Andreas Wernitz, Estefania Toledo, Dolores Corella, Angel Alonso-Gomez, Montse Fito, Enrique Gomez-Gracia, Ramon Estruch, Miquel Fiol, Jose Lapetra, Lluis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvado, Matthias B. Schulze, Miguel A. Martinez-Gonzalez
Summary: In the PREDIMED trial, a nutritional intervention with Mediterranean diets was found to affect the distribution of plasma phospholipid fatty acids (FAs), and 1-year changes in FAs were associated with subsequent cardiovascular risk.
CLINICAL CHEMISTRY
(2023)
Article
Oncology
Ziling Mao, Jacqueline Roshelli Baker, Masayoshi Takeuchi, Hideyuki Hyogo, Anne Tjonneland, Anne Kirstine Eriksen, Gianluca Severi, Joseph Rothwell, Nasser Laouali, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jeroen W. G. Derksen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, Jose Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Sophia Harlid, Ingegerd Johansson, Aurora Perez-Cornago, Heinz Freisling, Marc Gunter, Elisabete Weiderpass, Alicia K. Heath, Elom Aglago, Mazda Jenab, Veronika Fedirko
Summary: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) are associated with the development and progression of colorectal cancer due to their oxidative and inflammatory properties. This study found that circulating glycer-AGEs concentrations are positively associated with both colorectal cancer-specific and all-cause mortality. The association between glycer-AGEs and colorectal cancer-specific mortality is stronger in patients with distal colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Endocrinology & Metabolism
Armin Zittermann, Annemarie Schmidt, Julia Haardt, Nicole Kalotai, Andreas Lehmann, Sarah Egert, Sabine Ellinger, Anja Kroke, Stefan Lorkowski, Sandrine B. Louis, Matthias Schulze, Lukas Schwingshackl, Roswitha I. Siener, Gabriele Stangl, Dorothee Volkert, Bernhard A. Watzl, Heike Bischoff-Ferrari
Summary: This umbrella review aimed to assess the impact of protein intake exceeding the current recommendations for different age groups on bone health. The review analyzed systematic reviews of studies published between 2008 and 2021, evaluating the effect of both animal and plant protein. The overall certainty of evidence was found to be insufficient, except for a possible link between high protein intake and reduced hip fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Immunology
Thilo Samson Chillon, Gregor Weiss, Kamil Demircan, Waldemar B. Minich, Michael Schenk, Lutz Schomburg
Summary: A study compared the fertilization outcomes of vaccinated and non-vaccinated women and found no negative association between vaccination and fertilization success and oocyte development. The results support the safety of COVID-19 vaccination during assisted reproduction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Dorota Filipowicz, Ewelina Szczepanek-Parulska, Aniceta A. Mikulska-Sauermann, Marta Karazniewicz-Lada, Franciszek K. Glowka, Krzysztof Szymanowski, Mariusz Oltarzewski, Lutz Schomburg, Marek Ruchala
Summary: This study evaluated a group of women in western Poland to update iodine status during pregnancy and assess the effectiveness of iodine supplementation in relation to maternal and neonatal thyroid function. The results showed that the current iodine-deficiency prophylaxis model during pregnancy was ineffective despite national salt iodization and recommendations for iodine supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Enrique Almanza-Aguilera, Estefania Davila-Cordova, Daniel Guinon-Fort, Marta Farras, Giovanna Masala, Maria Santucci de Magistris, Ivan Baldassari, Rosario Tumino, Lisa Padroni, Verena A. Katzke, Matthias B. Schulze, Augustin Scalbert, Raul Zamora-Ros
Summary: This study analyzed the correlations between the acute and habitual intake of dietary tyrosols and their main food sources with urinary excretions of tyrosol and hydroxytyrosol. The results showed that urinary excretions correlated more strongly with acute intake than habitual intake. They also found correlations between urinary excretions and other tyrosol precursors as well as major food sources. Based on these findings, urinary excretions could be proposed as biomarkers of total tyrosol intake, especially for acute intakes.
Review
Nutrition & Dietetics
Matthias B. Schulze, Julia Haardt, Anna M. Amini, Nicole Kalotai, Andreas Lehmann, Annemarie Schmidt, Anette E. Buyken, Sarah Egert, Sabine Ellinger, Anja Kroke, Tilman Kuehn, Sandrine Louis, Katharina Nimptsch, Lukas Schwingshackl, Roswitha Siener, Armin Zittermann, Bernhard Watzl, Stefan Lorkowski
Summary: Protein intake is associated with the risk of type 2 diabetes, with total protein intake possibly increasing the risk and animal protein intake showing uncertain results. Further research is needed to clarify the relationship between protein intake and type 2 diabetes risk.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
David J. Hughes, Lutz Schomburg, Mazda Jenab, Carine Biessy, Catherine Meplan, Aurelie Moskal, Qian Sun, Kamil Demircan, Veronika Fedirko, Elisabete Weiderpass, Maryam Mukhtar, Anja Olsen, Anne Tjonneland, Kim Overvad, Matthias Schulze, Therese Haugdahl Nost, Guri Skeie, Karina Standahl Olsen, Fulvio Ricceri, Sara Grioni, Domenico Palli, Giovanna Masala, Rosario Tumino, Fabrizio Pasanisi, Pilar Amiano, Sandra M. Colorado Yohar, Antonio Agudo, Maria-Jose Sanchez, Eva Ardanaz, Malin Sund, Anne Andersson, Aurora Perez-Cornago, Ruth Travis, Alicia K. Heath, Laure Dossus
Summary: The study found no significant association between selenium status and breast cancer risk. However, higher activity of the selenoenzyme GPX3 was associated with a lower risk of premenopausal breast cancer. Several genetic variants were also found to be associated with breast cancer risk.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maria Maares, Alessia Haupt, Christoph Schuessler, Marcel Kulike-Koczula, Julian Hackler, Claudia Keil, Isabelle Mohr, Lutz Schomburg, Roderich D. Suessmuth, Hans Zischka, Uta Merle, Hajo Haase
Summary: This study introduces a fluorometric high throughput assay using the novel Cu2+ binding fluoresceine-peptide sensor FP4 to determine labile Cu2+ in human and rat serum. The labile Cu2+ concentration in human serum was found to be 0.14±0.05 pM, showing no correlation with age or other serum trace elements. The analysis of patients with Wilson's disease showed a significant decrease in labile Cu2+ following copper chelation therapy, suggesting its potential as a specific marker for disease status and treatment progress monitoring.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Meriem Ouni, Fabian Eichelmann, Markus Jaehnert, Christin Krause, Sophie Saussenthaler, Christiane Ott, Pascal Gottmann, Thilo Speckmann, Peter Huypens, Stefan Wolter, Oliver Mann, Martin Hrabe De Angelis, Johannes Beckers, Henriette Kirchner, Matthias B. Schulze, Annette Schuermann
Summary: Better disease management can be achieved by identifying novel epigenetic biomarkers that determine the risk of type 2 diabetes (T2D) at an early stage. This study found that differences in gene expression and DNA methylation in the liver could be used as potential biomarkers for T2D. The downregulation of the HAMP gene, associated with elevated DNA methylation, was identified as a potential early marker for T2D.
MOLECULAR METABOLISM
(2023)
Article
Oncology
Enrique Almanza-Aguilera, Daniel Guinon-Fort, Aurora Perez-Cornago, Miriam Martinez-Huelamo, Cristina Andres-Lacueva, Anne Tjonneland, Anne Kirstine Eriksen, Verena Katzke, Rashmita Bajracharya, Matthias B. Schulze, Giovanna Masala, Andreina Oliverio, Rosario Tumino, Luca Manfredi, Cristina Lasheras, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Emily Sonestedt, Anders Bjartell, Elin Thysell, Elisabete Weiderpass, Dagfinn Aune, Elom K. Aglago, Ruth C. Travis, Raul Zamora-Ros
Summary: In this large prospective cohort study, no association was found between (poly)phenol intake and the risk of prostate cancer among European men. This was observed for both overall intake and specific classes and subclasses of (poly)phenols.
