The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats are Possibly Mediated by Preventing Blood–Brain Barrier Disruption and RIP3-Mediated Necroptosis

Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway

(2019) Chunlei Yang et al.   Frontiers in Neuroscience

RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage

(2017) Keren Zhou et al.   EXPERIMENTAL NEUROLOGY

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

(2017) Jason K Karimy et al.   NATURE MEDICINE

Intranasal administration of recombinant Netrin-1 attenuates neuronal apoptosis by activating DCC/APPL-1/AKT signaling pathway after subarachnoid hemorrhage in rats

(2017) Zongyi Xie et al.   NEUROPHARMACOLOGY

The Role of Autophagy in Subarachnoid Hemorrhage: An Update

(2017) Yuanjian Fang et al.   Current Neuropharmacology

Necroptosis-independent signaling by the RIP kinases in inflammation

(2016) Kenta Moriwaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia

(2016) Raul Chavez-Valdez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Pharmacological Inhibition of PERK Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats Through the Activation of Akt

(2016) Feng Yan et al.   MOLECULAR NEUROBIOLOGY

Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression

(2016) Shenglong Cao et al.   NEUROSCIENCE LETTERS

Role of Lipocalin-2 in Thrombin-Induced Brain Injury

(2016) Shanshan Mao et al.   STROKE

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

(2016) Tao Liu et al.   Scientific Reports

MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage

(2016) Dewei Guo et al.   Translational Stroke Research

Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage

(2016) Jinwei Pang et al.   Translational Stroke Research

RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF

(2016) Yang Xu et al.   Scientific Reports

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

(2015) Bo Yin et al.   BRAIN RESEARCH

The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice

(2015) Zhenyu Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Lipocalin-2 in Brain Injury after Intracerebral Hemorrhage

(2015) Wei Ni et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

RIP1 Inhibition Rescues from LPS-Induced RIP3-Mediated Programmed Cell Death, Distributed Energy Metabolism and Spatial Memory Impairment

(2015) Sara Nikseresht et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats

(2015) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage

(2015) Jianru Li et al.   MOLECULAR NEUROBIOLOGY

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway

(2015) Xingfen Su et al.   NEUROCHEMICAL RESEARCH

White Matter Injury After Subarachnoid Hemorrhage

(2015) Yusuke Egashira et al.   STROKE

RIPK1- and RIPK3-induced cell death mode is determined by target availability

(2014) W D Cook et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis: Who Knew There were so Many Interesting Ways to Die?

(2014) S.M. Fayaz et al.   CNS & Neurological Disorders-Drug Targets

The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies

(2014) Elke Kooijman et al.   Journal of Neuroinflammation

Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines

(2014) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Anti-Necroptosis Chemical Necrostatin-1 Can Also Suppress Apoptotic and Autophagic Pathway to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model

(2013) Pan Chang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Structural Basis of RIP1 Inhibition by Necrostatins

(2013) Tian Xie et al.   STRUCTURE

Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research

(2013) Mutsumi Fujii et al.   Translational Stroke Research

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation

(2012) Weiwei Qin et al.   JOURNAL OF ENDOCRINOLOGY

Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage

(2012) C.-h. Jing et al.   NEUROSCIENCE

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage

(2012) E. Sander Connolly et al.   STROKE

Subarachnoid Hemorrhage-Induced Hydrocephalus in Rats

(2012) Shuichi Okubo et al.   STROKE

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

(2011) Yan Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Elevated Peripheral Neutrophils and Matrix Metalloproteinase 9 as Biomarkers of Functional Outcome Following Subarachnoid Hemorrhage

(2011) S. H.-Y. Chou et al.   Translational Stroke Research

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

(2010) Frances J Northington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Role of Interleukin-1β in Early Brain Injury After Subarachnoid Hemorrhage in Mice

(2009) Takumi Sozen et al.   STROKE

Structure–activity relationship study of a novel necroptosis inhibitor, necrostatin-7

(2008) Weihong Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Subarachnoid hemorrhage model in the rat: Modification of the endovascular filament model

(2008) Ik-Seong Park et al.   JOURNAL OF NEUROSCIENCE METHODS

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Subarachnoid Hemorrhage: Is It Time for a New Direction?

(2008) J. Cahill et al.   STROKE

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS