Article
Biochemistry & Molecular Biology
Xiao-Na Hao, Na Zhao, Jie-Min Huang, Si-Yu Li, Dong Wei, Ning Pu, Guang-Hua Peng, Ye Tao
Summary: This study investigated the role of ZYAN1, a PHD inhibitor, in a pharmacologically induced RD model. It was found that ZYAN1 treatment can alleviate progressive photoreceptor loss and oxidative damage in RD by enhancing mitophagy. ZYAN1 treatment increased the thickness of the ONL, preserved visual function, improved the structure of photoreceptor mitochondria, and increased the number of autophagosomes. Moreover, ZYAN1 treatment reduced membrane disc shedding and ROS overproduction, and improved the axonal cilia structure.
Article
Biochemistry & Molecular Biology
Elisabetta Catalani, Silvia Bongiorni, Anna Rita Taddei, Marta Mezzetti, Federica Silvestri, Marco Coazzoli, Silvia Zecchini, Matteo Giovarelli, Cristiana Perrotta, Clara De Palma, Emilio Clementi, Marcello Ceci, Giorgio Prantera, Davide Cervia
Summary: The absence of full-length dystrophin leads to structural damages and impaired autophagy in the retina, affecting neuronal survival and visual properties. Reactivation of autophagy can prevent cell death and structural changes, improving the response to light in mutant flies. Overall, functional dystrophin is crucial for synapsis stabilization and proper neuronal survival in the retina.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Bo-Yie Chen, Jyh-Cheng Liou, Jia-Lain Wu, Chao-Hsiang Chen, Shih-Liang Yang
Summary: Astragaloside IV showed protective effects against light-induced functional vision deterioration, especially on cone cells, improving visual acuity and contrast sensitivity function in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Naymel Alejandra Guzman Mendoza, Kohei Homma, Hideto Osada, Eriko Toda, Norimitsu Ban, Norihiro Nagai, Kazuno Negishi, Kazuo Tsubota, Yoko Ozawa
Summary: This study demonstrated that administration of an ER-stress inhibitor, 4-phenylbutyric acid (4-PBA), effectively suppressed light-induced visual function impairment and reduced photoreceptor cell apoptosis. Induction of ER stress in the light-exposed retina was attenuated by 4-PBA treatment, leading to suppression of oxidative stress and mitochondrial apoptosis.
Article
Biotechnology & Applied Microbiology
Kelly Hanna, Julio Nieves, Christine Dowd, Kristina Oresic Bender, Pallavi Sharma, Baljit Singh, Mark Renz, James N. Ver Hoeve, Diana Cepeda, Claire M. Gelfman, Brigit E. Riley, Ruslan N. Grishanin
Summary: Blue cone monochromacy (BCM) is a rare X-linked retinal disease characterized by the absence of L- and M-opsin in cone photoreceptors. ADVM-062, a vector optimized for cone-specific expression of human L-opsin, was administered using a single intravitreal (IVT) injection. Studies in gerbils and non-human primates demonstrated the potential of ADVM-062 as a one-time IVT gene therapy for BCM.
Article
Cell Biology
Ashish K. Solanki, Manas R. Biswal, Stephen Walterhouse, Rene Martin, Altaf A. Kondkar, Hans-Joachim Knolker, Bushra Rahman, Ehtesham Arif, Shahid Husain, Sandra R. Montezuma, Deepak Nihalani, Glenn Prazere Lobo
Summary: The unconventional myosin MYO1C plays a crucial role in rhodopsin localization to photoreceptor outer segments and is essential for normal visual function. Loss of MYO1C in mice leads to rhodopsin mislocalization, impaired photoreceptor function, and progressively shorter outer segments, indicating its significance in retinal cell physiology.
Article
Neurosciences
Rikard Frederiksen, Ala Morshedian, Sonia A. Tripathy, Tongzhou Xu, Gabriel H. Travis, Gordon L. Fain, Alapakkam P. Sampath
Summary: Rod photoreceptors can become saturated by bright background light, but recent experiments have shown that they can also recover sensitivity and maintain responses even under prolonged exposure to bright light. The reduction of translocation of G protein transducin in transgenic mice may affect the recovery ability, and a novel mechanism of visual-pigment regeneration within the rod itself enables them to remain responsive. This allows rods to avoid extended closure of transduction channels, which could lead to photoreceptor degeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Davide Garzone, Robert P. Finger, Matthias M. Mauschitz, Alexandra Koch, Martin Reuter, Monique M. B. Breteler, N. Ahmad Aziz
Summary: Visual impairment and retinal neurodegeneration are associated with cognitive impairment and brain atrophy. This study found that visual acuity and retinal neurodegeneration are both related to global brain and hippocampal atrophy, partially mediated through the disintegration of intermediate visual tracts. These findings indicate that OCT-derived retinal measures can be used as markers of neurodegeneration and emphasize the importance of transneuronal degeneration in the association between retinal neurodegeneration and brain atrophy.
HUMAN BRAIN MAPPING
(2023)
Review
Physiology
Rick H. Cote
Summary: This review article discusses the role of cGMP in the visual signaling pathway of the vertebrate retina, particularly focusing on the metabolism of cGMP in rod and cone photoreceptors. It highlights recent advances in understanding the structural and conformational changes involved in the activation of PDE6 by transducin and the regulation of its lifetime, as well as the potential therapeutic applications of pharmacological compounds targeting PDE6 in inherited retinal diseases.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Neurosciences
Tylor R. Lewis, Mustafa S. Makia, Carson M. Castillo, Muayyad R. Al-Ubaidi, Muna Naash, Vadim Y. Arshavsky
Summary: Mutations in the PRPH2 gene cause a broad range of retinal diseases by affecting the structure of outer segment of photoreceptor cells, resulting in irregular disc enclosure process. Abnormal PRPH2 oligomerization leads to defects in outer segment structure, particularly at the stage of disc enclosure.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Alexandra V. Garafalo, Rebecca Sheplock, Alexander Sumaroka, Alejandro J. Roman, Artur V. Cideciyan, Samuel G. Jacobson
Summary: Inherited retinal diseases (IRDs) encompass cone-rod diseases, which have complex etiologies and can lead to vision loss. Among the causative genes, there is diversity, leading to a variety of disease manifestations, and paving the way for potential therapies.
Article
Neurosciences
Kennedy Bolstad, Inigo Novales Flamarique
Summary: This study investigated the expression of opsins in the retina of Atlantic halibut undergoing eye migration. The results showed that double and triple cones were exclusively labeled with AB5407 antibody, while the majority of single cones were labeled with AHblue antibody. Some single cones in transition regions and near peripheral growth zones co-expressed at least two opsins. A nonrandom mosaic gradient of short wavelength (SWS2 expressing) cones was found from central to dorsal retina. The study suggests opsin switching as a mechanism for creating new cone spectral phenotypes.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Biology
Gregor Belusic, Marko Ilic, Andrej Meglic, Primoz Pirih
Summary: A novel class of green-sensitive photoreceptors, G+R- cells, have been discovered in butterflies, showing hyperpolarizing responses to red light and interacting with red opponent units R9. This mechanism has been found in various butterfly species, suggesting the potential for tetrachromacy in their visual systems.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Manuela Voelkner, Felix Wagner, Thomas Kurth, Alex M. Sykes, Claudia Del Toro Runzer, Lynn J. A. Ebner, Cagri Kavak, Vasileia Ismini Alexaki, Peter Cimalla, Mirko Mehner, Edmund Koch, Mike O. Karl
Summary: Neurodegenerative diseases are not fully understood and require therapies. Stem cell-derived organoid models are useful for research in fundamental and translational medicine. In this study, mouse retina organoids were tested with different manipulations, and it was found that they can reproduce distinct pathologic processes, including a complex pathology with combined neurodegeneration and glial pathologies. This research provides insights for further organoid optimization and modeling of differential phenotypes for future applications in research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Aritra Bej, James B. Ames
Summary: Retinal cyclic nucleotide-gated (CNG) ion channels play a crucial role in visual phototransduction. This review discusses the binding of calmodulin to CNGB1 subunits and its impact on channel desensitization and retinal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ye Tao, Zhao Ma, Bei Liu, Wei Fang, Limin Qin, Yi Fei Huang, Lu Wang, Yanling Gao
Article
Cell Biology
Weiming Yan, Pan Long, Tao Chen, Wei Liu, Lu Yao, Ze Ren, Xiangqian Li, Jiancong Wang, Junhui Xue, Ye Tao, Lei Zhang, Zuoming Zhang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Cell Biology
Ye Tao, Lei Ding, Anhui Yao, Zhen Yang, Qinghua Yang, Limin Qin, Linjun Yu, Yanling Gao, Yi Fei Huang, Zhengwei Li, Dengke Teng
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Ye Tao, Chong Li, Anhui Yao, Yingxin Qu, Limin Qin, Zuojun Xiong, Jianbin Zhang, Weiwen Wang
Article
Health Care Sciences & Services
Zhongyu Liu, Shuang Tian, Zhifeng Yan, Xiurong Yu, Xiuli Li, Ye Tao
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2019)
Article
Pharmacology & Pharmacy
Ye Tao, Qi Zhu, Liqiang Wang, Xiaobing Zha, Dengke Teng, Lei Xu
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2020)
Article
Chemistry, Medicinal
Ye Tao, Miao He, Qinghua Yang, Zhao Ma, Yingxin Qu, Wen Chen, Guanghua Peng, Dengke Teng
DRUG DESIGN DEVELOPMENT AND THERAPY
(2019)
Article
Pharmacology & Pharmacy
Chong Li, Yi Tian, Anhui Yao, Xiaobing Zha, Jianbin Zhang, Ye Tao
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ying Liu, Jichen Wang, Xin Jin, Zhiyuan Xin, Xing Wu, Xu Tong, Ye Tao, Dajiang Wang
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Article
Ophthalmology
Ye Tao, Lun Cai, Dawei Zhou, Chunhui Wang, Zhao Ma, Xiaofei Dong, Guanghua Peng
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Pharmacology & Pharmacy
Ye Tao, Yue Wang, Zhao Ma, Liqiang Wang, Limin Qin, Lu Wang, Yi Fei Huang, Shizhong Zhang
Review
Medicine, General & Internal
Meng Zhao, Ye Tao, Guang-Hua Peng
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Lei Xu, Haixiang Yu, Hongbin Sun, Xiang Yu, Ye Tao
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)