How the Membrane Attack Complex Damages the Bacterial Cell Envelope and Kills Gram‐Negative Bacteria

Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases

(2019) Dani AC Heesterbeek et al.   EMBO JOURNAL

Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics

(2019) D. A. C. Heesterbeek et al.   Scientific Reports

Single-molecule kinetics of pore assembly by the membrane attack complex

(2019) Edward S. Parsons et al.   Nature Communications

Publisher Correction: Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics

(2019) D. A. C. Heesterbeek et al.   Scientific Reports

The gram-negative bacterial periplasm: Size matters

(2018) Samuel I. Miller et al.   PLOS BIOLOGY

Advances in cryoEM and its impact on β-pore forming proteins

(2018) Courtney M Boyd et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications

(2018) Dani A.C. Heesterbeek et al.   Journal of Innate Immunity

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

(2018) Bradley A. Spicer et al.   Nature Communications

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

(2018) Anaïs Menny et al.   Nature Communications

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation

(2017) Thomas H. Sharp et al.   JOURNAL OF STRUCTURAL BIOLOGY

Real-time visualization of perforin nanopore assembly

(2017) Carl Leung et al.   Nature Nanotechnology

The mystery behind membrane insertion: a review of the complement membrane attack complex

(2017) Charles Bayly-Jones et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Molecular cell biology of complement membrane attack

(2017) B. Paul Morgan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Envelope Stress Responses: An Interconnected Safety Net

(2017) Marcin Grabowicz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protection of host cells by complement regulators

(2016) Christoph Q. Schmidt et al.   IMMUNOLOGICAL REVIEWS

Structure of the poly-C9 component of the complement membrane attack complex

(2016) Natalya V. Dudkina et al.   Nature Communications

Structural basis of complement membrane attack complex formation

(2016) Marina Serna et al.   Nature Communications

Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

(2016) Thomas H. Sharp et al.   Cell Reports

A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

(2016) Anna Konovalova et al.   eLife

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

(2015) Evelien T. M. Berends et al.   BMC BIOLOGY

Extracellular protease digestion to evaluate membrane protein cell surface localization

(2015) Richard N Besingi et al.   Nature Protocols

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

(2014) Carl Leung et al.   eLife

Distinct localization of the complement C5b-9 complex on Gram-positive bacteria

(2013) Evelien T. M. Berends et al.   CELLULAR MICROBIOLOGY

Killing machines: three pore-forming proteins of the immune system

(2013) Ryan McCormack et al.   IMMUNOLOGIC RESEARCH

Meningococcal disease and the complement system

(2013) Lisa A Lewis et al.   Virulence

Structure, Function and Control of Complement C5 and its Proteolytic Fragments

(2012) N. S. Laursen et al.   CURRENT MOLECULAR MEDICINE

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

(2012) Michelle A Dunstone et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

(2012) Michael A. Hadders et al.   Cell Reports

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement

(2011) Leslie L. Lovelace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy

(2010) M. Hartmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an α-helical ‘sequence template’

(2008) U. Pag et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY