Meningococcal disease and the complement system

Meningococcal Sepsis Complicating Eculizumab Treatment Despite Prior Vaccination

(2013) G. H. Struijk et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

(2013) Peter Hillmen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Environmental survival of Neisseria meningitidis

(2013) Y.-L. TZENG et al.   EPIDEMIOLOGY AND INFECTION

Genetic susceptibility to meningococcal infection

(2013) Adam P Dale et al.   Expert Review of Anti-Infective Therapy

Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)

(2013) G. Saggu et al.   JOURNAL OF IMMUNOLOGY

Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease

(2013) L. K. McNeil et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Production Process for Native Outer Membrane Vesicle Vaccine against Neisseria meningitidis

(2013) Bas van de Waterbeemd et al.   PLoS One

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Meningococcemia Cutaneous Lesions Involve Meningococcal Perivascular Invasion Through the Remodeling of Endothelial Barriers

(2012) Nicolas Dupin et al.   CLINICAL INFECTIOUS DISEASES

Complement dysregulation and disease: From genes and proteins to diagnostics and drugs

(2012) Santiago Rodriguez de Cordoba et al.   IMMUNOBIOLOGY

Genetic susceptibility to invasive meningococcal disease: MBL2 structural polymorphisms revisited in a large case-control study and a systematic review

(2012) D. T. Bradley et al.   International Journal of Immunogenetics

The Relative Roles of Factor H Binding Protein, Neisserial Surface Protein A, and Lipooligosaccharide Sialylation in Regulation of the Alternative Pathway of Complement on Meningococci

(2012) L. A. Lewis et al.   JOURNAL OF IMMUNOLOGY

Involvement of three meningococcal surface-exposed proteins, the heparin-binding protein NhbA, the α-peptide of IgA protease and the autotransporter protease NalP, in initiation of biofilm formation

(2012) Jesús Arenas et al.   MOLECULAR MICROBIOLOGY

Opc Expression, LPS Immunotype Switch and Pilin Conversion Contribute to Serum Resistance of Unencapsulated Meningococci

(2012) Kerstin Hubert et al.   PLoS One

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: Immunological, functional and structural characterization of the antigens

(2012) Davide Serruto et al.   VACCINE

The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein

(2012) Peter T. Beernink et al.   PLoS Pathogens

Characterization of Neisseria meningitidis Isolates That Do Not Express the Virulence Factor and Vaccine Antigen Factor H Binding Protein

(2011) Jay Lucidarme et al.   Clinical and Vaccine Immunology

Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding

(2011) Serena Giuntini et al.   INFECTION AND IMMUNITY

Meningococcal Group W-135 and Y Capsular Polysaccharides Paradoxically Enhance Activation of the Alternative Pathway of Complement

(2011) Sanjay Ram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Blocking Human IgG Directed against the Pentapeptide Repeat Motifs of Neisseria meningitidis Lip/H.8 and Laz Lipoproteins

(2011) T. Dutta Ray et al.   JOURNAL OF IMMUNOLOGY

A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination

(2011) P. T. Beernink et al.   JOURNAL OF IMMUNOLOGY

Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood

(2011) Ole-Lars Brekke et al.   MOLECULAR IMMUNOLOGY

Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance

(2011) Natalie J. Griffiths et al.   MOLECULAR MICROBIOLOGY

Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria

(2011) Laty A. Cahoon et al.   MOLECULAR MICROBIOLOGY

Eculizumab in Severe Shiga-Toxin–Associated HUS

(2011) Anne-Laure Lapeyraque et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insufficient protection by Neisseria meningitidis vaccination alone during eculizumab therapy

(2011) Antonia Bouts et al.   PEDIATRIC NEPHROLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between coagulation and complement—their role in inflammation

(2011) Katerina Oikonomopoulou et al.   Seminars in Immunopathology

Transcriptome Analysis of Neisseria meningitidis in Human Whole Blood and Mutagenesis Studies Identify Virulence Factors Involved in Blood Survival

(2011) Hebert Echenique-Rivera et al.   PLoS Pathogens

Complement regulator factor H as a serum biomarker of multiple sclerosis disease state

(2010) Gillian Ingram et al.   BRAIN

Prevalence of hereditary properdin, C7 and C8 deficiencies in patients with meningococcal infections

(2010) M. SCHLESINGER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vaccination of patients deficient in a late complement component with tetravalent meningococcal capsular polysaccharide vaccine

(2010) A. E. PLATONOV et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy

(2010) S. Ram et al.   CLINICAL MICROBIOLOGY REVIEWS

Native Properdin Binds toChlamydia pneumoniaeand Promotes Complement Activation

(2010) Claudio Cortes et al.   INFECTION AND IMMUNITY

An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae

(2010) S. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Biofilm formation by the human pathogen Neisseria meningitidis

(2010) Martin Lappann et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease

(2010) Sonia Davila et al.   NATURE GENETICS

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans

(2010) Davide Serruto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults

(2010) C. A. MacLennan et al.   SCIENCE

Neisseria meningitidis Opc Invasin Binds to the Sulphated Tyrosines of Activated Vitronectin to Attach to and Invade Human Brain Endothelial Cells

(2010) Claudia Sa E Cunha et al.   PLoS Pathogens

The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to Complement

(2010) Lisa A. Lewis et al.   PLoS Pathogens

Severity of Meningococcal Disease Associated with Genomic Bacterial Load

(2009) Tom Darton et al.   CLINICAL INFECTIOUS DISEASES

Clinical and laboratory evidence forNeisseria meningitidisbiofilms

(2009) R Brock Neil et al.   Future Microbiology

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Critical Roles of Complement and Antibodies in Host Defense Mechanisms against Neisseria meningitidis as Revealed by Human Complement Genetic Deficiencies

(2009) B. C. Hellerud et al.   INFECTION AND IMMUNITY

Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules

(2009) M.-A. Rameix-Welti et al.   INFECTION AND IMMUNITY

Functional Comparison of the Binding of Factor H Short Consensus Repeat 6 (SCR 6) to Factor H Binding Protein from Neisseria meningitidis and the Binding of Factor H SCR 18 to 20 to Neisseria gonorrhoeae Porin

(2009) J. Shaughnessy et al.   INFECTION AND IMMUNITY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

(2009) Muriel C. Schneider et al.   NATURE

Immunogenicity and Tolerability in Infants of a New Zealand Epidemic Strain Meningococcal B Outer Membrane Vesicle Vaccine

(2009) Sharon H. Wong et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Biology and pathogenesis of the evolutionarily successful, obligate human bacterium Neisseria meningitidis

(2009) David S. Stephens   VACCINE

Naturally Occurring Lipid A Mutants in Neisseria meningitidis from Patients with Invasive Meningococcal Disease Are Associated with Reduced Coagulopathy

(2009) Floris Fransen et al.   PLoS Pathogens

Stages of Meningococcal Sepsis Simulated In Vitro, with Emphasis on Complement and Toll-Like Receptor Activation

(2008) B. C. Hellerud et al.   INFECTION AND IMMUNITY

Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera

(2008) D. M. Granoff et al.   INFECTION AND IMMUNITY

Use of an observational cohort study to estimate the effectiveness of the New Zealand group B meningococcal vaccine in children aged under 5 years

(2008) Y. Galloway et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A generic mechanism inNeisseria meningitidisfor enhanced resistance against bactericidal antibodies

(2008) Maria Jose Uria et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of complement in the success of vaccination with conjugated vs. unconjugated polysaccharide antigen

(2008) Nur’ain Salehen et al.   VACCINE

The Regulatory SCR-1/5 and Cell Surface-binding SCR-16/20 Fragments of Factor H Reveal Partially Folded-back Solution Structures and Different Self-associative Properties

(2007) Azubuike I. Okemefuna et al.   JOURNAL OF MOLECULAR BIOLOGY