Biosynthesis of Polyketides in Streptomyces

Rapid identification of Streptomyces tetracycline producers by MALDI-TOF mass spectrometry

(2018) Lukas Hleba et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Manipulation of two regulatory genes for efficient production of chromomycins in Streptomyces reseiscleroticus

(2018) Lei Sun et al.   Journal of Biological Engineering

Secondary Metabolites Produced during the Germination of Streptomyces coelicolor

(2017) Matouš Čihák et al.   Frontiers in Microbiology

Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase

(2016) S. Vance et al.   BIOCHEMICAL JOURNAL

Overexpression of a pathway specific negative regulator enhances production of daunorubicin in bldA deficient Streptomyces peucetius ATCC 27952

(2016) Anaya Raj Pokhrel et al.   MICROBIOLOGICAL RESEARCH

Exploiting the Biosynthetic Potential of Type III Polyketide Synthases

(2016) Yan Lim et al.   MOLECULES

Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans

(2015) Ekaterina Shelest et al.   BMC GENOMICS

Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae)

(2015) Gurjeet S. Kohli et al.   BMC GENOMICS

Lovastatin-producing endophytic fungus isolated from a medicinal plantSolanum xanthocarpum

(2015) Ramalingam Parthasarathy et al.   NATURAL PRODUCT RESEARCH

Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates

(2015) William D. Fiers et al.   Chemical Science

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Alkyldihydropyrones, new polyketides synthesized by a type III polyketide synthase from Streptomyces reveromyceticus

(2014) Teruki Aizawa et al.   JOURNAL OF ANTIBIOTICS

Doxorubicin, DNA torsion, and chromatin dynamics

(2013) Fan Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Future potential for anti-infectives from bacteria – How to exploit biodiversity and genomic potential

(2013) Rolf Müller et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase

(2013) Xiaoyu Tang et al.   Nature Chemical Biology

Kinetics of rapamycin production by Streptomyces hygroscopicus MTCC 4003

(2013) Subhasish Dutta et al.   3 Biotech

Type III polyketide synthases in natural product biosynthesis

(2012) Dayu Yu et al.   IUBMB LIFE

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor

(2012) Joseph A. Chemler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

StreptomeDB: a resource for natural compounds isolated from Streptomyces species

(2012) X. Lucas et al.   NUCLEIC ACIDS RESEARCH

Analysis of the Ketosynthase-Chain Length Factor Heterodimer from the Fredericamycin Polyketide Synthase

(2011) Ping-Hui Szu et al.   CHEMISTRY & BIOLOGY

Rapamycin Exerts Antifungal Activity In Vitro and In Vivo against Mucor circinelloides via FKBP12-Dependent Inhibition of Tor

(2011) Robert J. Bastidas et al.   EUKARYOTIC CELL

Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

(2011) Muftah A. M. Shushni et al.   Marine Drugs

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases

(2011) David H. Kwan et al.   MOLECULES

A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis

(2011) Tom Bretschneider et al.   Nature Chemical Biology

Oxytetracycline Biosynthesis

(2010) Lauren B. Pickens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism and Engineering of Polyketide Chain Initiation in Fredericamycin Biosynthesis

(2010) Abhirup Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Limitations in doxorubicin production from Streptomyces peucetius

(2010) Sailesh Malla et al.   MICROBIOLOGICAL RESEARCH

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

In Vivo and In Vitro Analysis of the Hedamycin Polyketide Synthase

(2009) Abhirup Das et al.   CHEMISTRY & BIOLOGY

Biosynthesis of Actinorhodin and Related Antibiotics: Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster

(2009) Susumu Okamoto et al.   CHEMISTRY & BIOLOGY

Biosynthesis of Aliphatic Polyketides by Type III Polyketide Synthase and Methyltransferase in Bacillus subtilis

(2009) C. Nakano et al.   JOURNAL OF BACTERIOLOGY

Antimicrobial Activities of Jadomycin B and Structurally Related Analogues

(2008) D. L. Jakeman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polyketides in insects: ecological role of these widespread chemicals and evolutionary aspects of their biogenesis

(2008) Florian Pankewitz et al.   BIOLOGICAL REVIEWS

A Type I/Type III Polyketide Synthase Hybrid Biosynthetic Pathway for the Structurally UniqueansaCompound Kendomycin

(2008) Silke C. Wenzel et al.   CHEMBIOCHEM

Elucidation of Oxygenation Steps during Oviedomycin Biosynthesis and Generation of Derivatives with Increased Antitumor Activity

(2008) Felipe Lombó et al.   CHEMBIOCHEM

Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Hosts

(2008) Y. Chen et al.   JOURNAL OF BACTERIOLOGY

Phenolic Lipids Synthesized by Type III Polyketide Synthase Confer Penicillin Resistance onStreptomyces griseus

(2008) Masanori Funabashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS