期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 304, 期 1, 页码 3-13出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2013.09.004
关键词
Antibiotics; Myxobacteria; Actinobacteria; Biodiversity; Genomic potential
The early stages of antibiotic development include the identification of novel hit compounds. Since actinomycetes and myxobacteria are still the most important natural sources of active metabolites, we provide an overview on these producers and discuss three of the most promising approaches toward finding novel anti-infectives from microorganisms. These are defined as the use of biodiversity to find novel producers, the variation of culture conditions and induction of silent genes, and the exploitation of the genomic potential of producers via genome mining. Challenges that exist beyond compound discovery are outlined in the last section. (C) 2013 Elsevier GmbH. All rights reserved.
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