Article
Chemistry, Applied
Maria Alessia Schouten, Silvia Tappi, Simone Angeloni, Manuela Cortese, Giovanni Caprioli, Sauro Vittori, Santina Romani
Summary: The study found that during the coffee roasting process, acrylamide levels and antioxidant activity reached a peak at lower roasting degrees, then decreased as heating time increased. The thermal reduction had a greater impact on acrylamide compared to antioxidant activity, as there was a balance between the degradation and formation of antioxidant compounds.
Article
Food Science & Technology
Yu-Chen Liao, Taejo Kim, Juan L. Silva, Wu-Yueh Hu, Bang-Yuan Chen
Summary: This study investigated the antioxidant activity and phenolic composition changes in coffee beans from different geographic origins and roasting degrees. The results showed that roasting degree had minimal impact on antioxidant activity and total phenolic content, but affected the levels of different phenolic compounds. Roasting could enhance the formation of purpurogallin and other phenolic compounds, compensating for the decrease in antioxidant activity due to the breakdown of chlorogenic acid.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hak Jun Lee, Ji In Park, Sung Ok Kwon, Daniel Duck-Jin Hwang
Summary: This study evaluated the association between coffee consumption and the prevalence of diabetic retinopathy (DR) in a Korean population, and found that coffee consumption is negatively associated with the risk of DR in Koreans with diabetes, especially those aged <65.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Alla Yegorova, Yuliia Skrypynets, Inna Leonenko, Axel Duerkop
Summary: This study presents a simple, sensitive, and validated method for determining the content of chlorogenic acid in green and roasted coffee, without the need for chromatographic separation. The method utilizes luminescence intensity quenching to measure the concentration of chlorogenic acid. The results showed that the method is effective and can be applied for quality control of chlorogenic acid in coffee.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Muchtaridi Muchtaridi, Dwintha Lestari, Nur Kusaira Khairul Ikram, Amirah Mohd Gazzali, Maywan Hariono, Habibah A. Wahab
Summary: Research has shown that decaffeination significantly reduces the levels of caffeine and chlorogenic acid in coffee beans. Different samples from various regions exhibit varying levels of NA inhibitory activity against H5N1 neuraminidase.
Review
Biochemistry & Molecular Biology
Qi Ding, Yan-Ming Xu, Andy T. Y. Lau
Summary: This review discusses the epigenetic effects of coffee extract and its three essential active ingredients (caffeine, chlorogenic acid, and caffeic acid). Coffee, as a popular beverage, contains active ingredients with various biological functions such as insulin sensitization, improvement of sugar metabolism, antidiabetic properties, and liver protection. However, recent studies have shown that coffee can have both beneficial and detrimental effects on human health due to its complex components. It has been found that coffee extract and its components can potentially influence gene expression through epigenetic modifications, such as DNA methylation, histone modifications, and ncRNA expression, which can have long-lasting impacts on the epigenome. Importantly, the consumption of coffee during pregnancy has been associated with negative effects on offspring due to epigenetic modifications, while it has also been linked to improvements in various diseases, including cancer. Therefore, understanding the epigenetic effects associated with coffee components is crucial for improving human health.
Article
Agriculture, Multidisciplinary
Jefyne Campos Carrera, Ray Rodrigues de Souza, Ana Claudia Gama Batista, Gabriela Aguiar Campolina, Francides Gomes da Silva, Manuel Losada Gavilanes, Rubens Jose Guimaraes, Maria das Gracas Cardoso, Fabio Akira Mori
Summary: The study found that coffee stems accumulate multiple compounds, such as chlorogenic acid, vanillin, and resveratrol, with their presence depending on the type of fertilization. Optimal performance was observed at the highest concentration tested (500 μg/mL) in all samples, with doses of 70% and 100% showing the best values for most concentrations. This highlights the potential for reuse of coffee stem residues as profitable antioxidant material.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Microbiology
Nikhil S. Bhandarkar, Peter Mouatt, Marwan E. Majzoub, Torsten Thomas, Lindsay Brown, Sunil K. Panchal
Summary: The study found that supplementing the diet with freeze-dried coffee pulp can improve symptoms of metabolic syndrome induced by high-carbohydrate, high-fat diet, reduce body weight, improve cardiovascular health and liver function, and modulate gut microbiota.
Review
Nutrition & Dietetics
Elza Bevilacqua, Vinicius Cruzat, Indu Singh, Roselyn B. Rose'Meyer, Sunil K. Panchal, Lindsay Brown
Summary: Coffee is a popular and widely consumed beverage worldwide, with potential health benefits such as reduced risks of cardiovascular disease, cancers, and liver disease. This study focuses on investigating the health effects and potential applications of spent coffee grounds (SCG), which contain bioactive compounds similar to coffee and have shown positive effects on metabolic parameters, gut microbiome, and energy consumption. SCG utilization could also contribute to reducing global waste from coffee production. Overall, SCG shows promise in moderating chronic human diseases and decreasing environmental impact.
Article
Plant Sciences
Joyce Alves Goulart da Silva, Mario Lucio Vilela de Resende, Ingridy Simone Ribeiro, Adriene Ribeiro Lima, Luiz Roberto Marques Albuquerque, Ana Cristina Andrade Monteiro, Matheus Henrique Brito Pereira, Deila Magna dos Santos Botelho
Summary: This study compared the chemical composition and antioxidant activity of leaf extracts from a partially resistant coffee cultivar and a susceptible cultivar to bacterial halo blight. The partially resistant cultivar showed higher content of phenolic compounds and flavonoids, as well as higher antioxidant activity.
Article
Chemistry, Applied
Carla Levi Oliveira Correa, Edmar das Merces Penha, Marianna Ramos dos Anjos, Sidney Pacheco, Otniel Freitas-Silva, Aderval Severino Luna, Leda Maria Fortes Gottschalk
Summary: A factorial design study using asparaginase treatment on arabica coffee beans showed a reduction in acrylamide content with the enzyme load, hydrolysis time, and water content as key factors. Statistical analysis revealed the importance of steam pretreatment for coffee beans, and the optimal conditions for reducing acrylamide content were identified. Asparaginase treatment did not impact the major bioactive compounds in coffee.
Article
Multidisciplinary Sciences
E. S. Harsha Haridas, Susmita Bhattacharya, M. K. Ravi Varma, Goutam Kumar Chandra
Summary: Selection of plant extracts as bioactive phytochemical source to synthesize nanoparticles is highly demanding due to their biocompatibility, nontoxicity, and cost-effectiveness. In this study, Coffee arabica leaf extracts (CAE) were used to produce highly stable silver nanoparticles (AgNPs), and the mechanism of bio reduction, capping, and stabilization mediated by 5-caffeoylquinic acid (5-CQA) is discussed. The green synthesized NPs were characterized using various techniques, and the affinity of 5-CQA capped CAE-AgNPs for thiol moiety of amino acid was utilized for sensitive detection of L-cysteine (L-Cys).
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Luigi Castaldo, Marianna Toriello, Raffaele Sessa, Luana Izzo, Sonia Lombardi, Alfonso Narvaez, Alberto Ritieni, Michela Grosso
Summary: The study showed that digested coffee has higher polyphenol content and antioxidant activity, reducing intracellular reactive oxygen species and interleukin-6 levels while causing fewer cytotoxic effects. These findings suggest that coffee may have antioxidant and anti-inflammatory properties, with the digestion process releasing compounds with higher bioactivity.
Review
Biochemistry & Molecular Biology
Katarzyna Socala, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Piotr Wlaz
Summary: Coffee contains various bioactive components that are beneficial for human health, such as caffeine, polyphenols, and alkaloids. Research suggests that regular coffee consumption can reduce the risk of cardiovascular diseases, type 2 diabetes, obesity, and certain types of cancer, while also potentially lowering the risk of neurodegenerative conditions like Alzheimer's and Parkinson's diseases. Further studies are needed to fully understand the mechanisms behind these effects and the therapeutic applications of coffee bioactive components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Boris Nemzer, John Edwards, Diganta Kalita
Summary: In this study, the structural analysis of caffeine-enriched whole coffee cherry extracts was investigated using H-1 and C-13 NMR spectroscopy. It was found that caffeine forms complexes with chlorogenic acids in aqueous solution, and the effect of complexation on the peak position of caffeoylquinic acid and caffeine resonance was studied.
Review
Biochemistry & Molecular Biology
Rajnish Kumar, Farhat Ullah Khan, Anju Sharma, Izzatdin B. A. Aziz, Nitesh Kumar Poddar
Summary: There has been significant progress in the use of artificial intelligence algorithms in medical applications over the past two decades. AI-assisted programs are already being used for remote health monitoring, and various AI-based prediction models have been developed for the detection and decision support of gastrointestinal, hepatic, and pancreatic diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Anju Sharma, Bishal Kumar Saha, Rajnish Kumar, Pritish Kumar Varadwaj
Summary: The sense of smell is a complex process that involves various stages from odorants entering the nose to the brain recognizing the associated odor. OlfactionBase is a free web server that aims to gather knowledge about olfaction mechanisms in one place, providing detailed information on odors, odorants, and related components to aid in the understanding of olfaction.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemical Research Methods
Anju Sharma, Rajnish Kumar, Rahul Semwal, Imlimaong Aier, Pankaj Tyagi, Pritish K. Varadwaj
Summary: This paper proposes a deep neural network architecture called DeepOlf, which uses molecular features and fingerprints of odorants and olfactory receptors (ORs) to predict whether a chemical compound is a potential odorant and determine its interacting OR. The deep-neural network framework fits data with better accuracy compared to other classical methods and accurately predicts odorant-OR interactions. This study is the first to apply deep learning ideas to the problem of odorant and interacting OR prediction.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Manisha Pritam, Garima Singh, Rajnish Kumar, Satarudra Prakash Singh
Summary: Mucormycosis is a deadly fungal disease caused by Rhizopus oryzae. The ongoing COVID-19 pandemic has led to a significant increase in mucormycosis cases. This study presents the design of a multi-epitope vaccine using reverse vaccinology and immunoinformatics approaches, potentially improving the efficacy of treatment for mucormycosis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Environmental Sciences
Vivek K. Gaur, Shivangi Gupta, Poonam Sharma, Pallavi Gupta, Sunita Varjani, Janmejai Kumar Srivastava, Jo-Shu Chang, Xuan-Thanh Bui
Summary: Microplastics, as a ubiquitous pollutant, have severe environmental and human health hazards. Microorganisms have evolved the tools to degrade different types of plastic polymers, but the degradation process is long. Meta omics approaches and protein engineering have been employed to identify active microbiota and mitigate microplastic contamination. Increasing plastic contamination serves as a breeding ground for other persistent chlorinated pollutants. This comprehensive review summarizes the sources, toxicity, and bio-based mitigation approaches for microplastics, providing insights into multi-omic approaches and engineering technologies for microplastic degradation. Guidelines and regulations are also discussed, along with knowledge gaps and opportunities for further research.
CURRENT POLLUTION REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Vivek K. Gaur, Poonam Sharma, Shivangi Gupta, Sunita Varjani, J. K. Srivastava, Jonathan W. C. Wong, Huu Hao Ngo
Summary: This article presents recent technological advancements in biosurfactant research, including the use of metabolomic and sequence based omics approaches, as well as tailoring strategies to improve production. Biosurfactants play a crucial role in addressing pollution in terrestrial and aquatic ecosystems.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Review
Neurosciences
Rajnish Kumar, Faiza Fatima, Garima Yadav, Simran Singh, Subhagata Haldar, Athanasios Alexiou, Ghulam Md Ashraf
Summary: Recent findings suggest that epigenetic mechanisms are necessary for the development and maintenance of neuron networks in the brain, influencing high-order brain processes and playing crucial roles in neurodegenerative and psychiatric conditions. The role of estrogen and androgen-based epigenetic changes in the brain is critical for the understanding of Alzheimer's disease (AD) and potential therapeutic strategies. This review highlights the epigenetic modifications caused by these two gonadal steroids and their implications for AD treatment.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Environmental Sciences
Vivek Kumar Gaur, Krishna Gautam, Poonam Sharma, Pallavi Gupta, Shreya Dwivedi, Janmejai Kumar Srivastava, Sunita Varjani, Huu Hao Ngo, Sang-Hyoun Kim, Jo-Shu Chang, Xuan-Thanh Bui, Mohammad J. Taherzadeh, Roberto Parra-Saldivar
Summary: Mobil oil, which is widely used in automobiles and machines, poses serious health hazards to humans and the environment due to its combustion. Recent advancements in research have led to the development of more efficient microbial-based strategies for remediation. This systematic review aims to provide valuable insights for the design of effective and feasible bioremediation strategies for ecosystems contaminated with mobil oil or petroleum hydrocarbons.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Vivek Kumar Gaur, Ranjna Sirohi, Mohd Ishfaq Bhat, Krishna Gautam, Poonam Sharma, Janmejai Kumar Srivastava, Ashok Pandey
Summary: The recent studies have shown that micro/nano plastics and antimicrobial resistance genes have harmful effects on the environment and human health. However, there is a lack of research on the interactions between these two factors and their combined influence. The interaction of microplastics has led to the formation of new plastics such as plastiglomerates, pyroplastics, and anthropoquinas. Additionally, the occurrence of microplastics has been found to contribute to the emergence of antimicrobial resistance genes and other pollutants such as polyaromatic hydrocarbons and pesticides. The excessive use of antibiotics following the Covid outbreak has further exacerbated the detrimental effects on human health. This study highlights the relationship between microplastics and antibiotic resistance generation, evaluates the factors of uncontrolled antibiotic use and negligent plastic consumption, and provides future research prospects to accurately assess the serious environmental occurrence of these pollutants.
Review
Genetics & Heredity
Anju Sharma, Rajnish Kumar, Pritish Varadwaj
Summary: Breath analysis is a promising field of research that can be used for disease diagnosis by identifying disease-specific variations in volatile organic components (VOCs) in breath. Extensive clinical trials are needed to establish the robustness of disease diagnosis and identify specific VOCs associated with illness states.
MOLECULAR DIAGNOSIS & THERAPY
(2023)
Article
Oncology
Anju Sharma, Rajnish Kumar, Garima Yadav, Prabha Garg
Summary: Artificial intelligence (AI) algorithms have made significant advancements in disease detection and decision support for healthcare professions in the past decade. They have been widely applied in gastroenterology for endoscopic analysis to diagnose intestinal cancers, premalignant polyps, gastrointestinal inflammatory lesions, and bleeding. AI has the potential to predict patients' treatment responses and prognoses by combining multiple algorithms. However, the rigorous validation of AI approaches through randomized controlled studies is necessary before widespread clinical use. This article discusses the recent applications, limitations, and challenges of deploying AI systems to diagnose intestinal malignancies and premalignant lesions.
Article
Ophthalmology
Rajnish Kumar, Devansh M. Sinha, Brenden R. Lankau, Nishant R. Sinha, Ratnakar Tripathi, Suneel Gupta, Rajiv R. Mohan
Summary: This study conducted transcriptome profiling of sulfur mustard-damaged and undamaged rabbit corneas to gain a better understanding of the mechanisms and develop specific therapies. The analysis identified differentially expressed genes and analyzed the signaling pathways and protein-protein interactions associated with cell proliferation and differentiation. Potential protein targets for corneal fibrosis and wound healing were identified.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Ophthalmology
Rajnish Kumar, Nishant R. Sinha, Rajiv R. Mohan
Summary: The cornea is the transparent front part of the eye with refraction and barrier functions, and corneal diseases are the leading cause of vision impairment globally. Conventional drugs and corneal transplant surgery are limited in treating severe corneal pathologies. Therefore, there is a high desire to develop nonsurgical methods, such as gene therapy, to cure corneal disorders and restore vision.
Review
Environmental Sciences
Rajnish Kumar, Garima Yadav, Mohammed Kuddus, Ghulam Md Ashraf, Rachana Singh
Summary: The metagenomics approach revolutionized the study of genetic information from uncultured microbes and complex microbial communities. In silico research allowed for a better understanding of protein interactions, drug design, and microbial evolution. Artificial intelligence, particularly machine learning and deep learning, has enabled the analysis and utilization of large datasets generated from nucleic acid sequencing and proteomics, leading to breakthroughs in microbiology research.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
P. Yadav, M. Sen, J. K. Srivastava, A. Das, T. Chatterji
Summary: Cryptococcal infection is a common opportunistic fungal infection seen in HIV patients, which can lead to severe complications such as subacute meningitis and bone marrow infection. Bone marrow aspirate and biopsy play an important role in the diagnosis and treatment of cryptococcal infection in HIV-infected patients.
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2022)
