Structural insights into the design of novel anti-influenza therapies

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus

(2017) Nicholas C. Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Unique Structural Features of Influenza Virus H15 Hemagglutinin

(2017) Netanel Tzarum et al.   JOURNAL OF VIROLOGY

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

(2017) Eva-Maria Strauch et al.   NATURE BIOTECHNOLOGY

A peptide mimic of an antibody

(2017) Timothy A. Whitehead   SCIENCE

Potent peptidic fusion inhibitors of influenza virus

(2017) Rameshwar U. Kadam et al.   SCIENCE

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in V H 1-69 Antibody Orientation on the HA Stem

(2017) Shanshan Lang et al.   Cell Reports

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

(2016) M. Gordon Joyce et al.   CELL

Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol

(2016) Rameshwar U. Kadam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stalking influenza by vaccination with pre-fusion headless HA mini-stem

(2016) Sophie A. Valkenburg et al.   Scientific Reports

Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

(2015) Aaron G. Schmidt et al.   CELL

Structure and Receptor Binding of the Hemagglutinin from a Human H6N1 Influenza Virus

(2015) Netanel Tzarum et al.   Cell Host & Microbe

A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors

(2015) Heng Zhang et al.   Cell Host & Microbe

Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference

(2015) F. Wang et al.   EMBO JOURNAL

Structure and Receptor Binding Preferences of Recombinant Hemagglutinins from Avian and Human H6 and H10 Influenza A Virus Subtypes

(2015) Hua Yang et al.   JOURNAL OF VIROLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses

(2015) Teddy John Wohlbold et al.   VACCINE

Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 Subtype

(2015) V. Vamsee Aditya Mallajosyula et al.   Frontiers in Immunology

Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets

(2014) F. Krammer et al.   JOURNAL OF VIROLOGY

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

(2014) V. V. A. Mallajosyula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

(2014) Yuval Avnir et al.   PLoS Pathogens

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

(2013) Gerald Nakamura et al.   Cell Host & Microbe

Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6

(2013) X. Lu et al.   JOURNAL OF VIROLOGY

Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site

(2013) M. Hong et al.   JOURNAL OF VIROLOGY

Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

(2013) C. Dreyfus et al.   JOURNAL OF VIROLOGY

Structural Analysis of the Hemagglutinin from the Recent 2013 H7N9 Influenza Virus

(2013) H. Yang et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin

(2013) Rui Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

(2013) R. P. Ringe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential Recognition of Avian-Like Receptors in Human Influenza A H7N9 Viruses

(2013) R. Xu et al.   SCIENCE

Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses

(2013) Y. Shi et al.   SCIENCE

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Design of Escherichia coli-Expressed Stalk Domain Immunogens of H1N1 Hemagglutinin That Protect Mice from Lethal Challenge

(2012) G. Bommakanti et al.   JOURNAL OF VIROLOGY

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

(2012) Timothy A Whitehead et al.   NATURE BIOTECHNOLOGY

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

(2012) A. G. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin

(2011) J. C. Krause et al.   JOURNAL OF VIROLOGY

Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5

(2011) N. Ohshima et al.   JOURNAL OF VIROLOGY

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

(2010) G. Bommakanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

(2010) R. Xu et al.   SCIENCE

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus

(2010) Wei Zhang et al.   Protein & Cell

Structure, Receptor Binding, and Antigenicity of Influenza Virus Hemagglutinins from the 1957 H2N2 Pandemic

(2009) R. Xu et al.   JOURNAL OF VIROLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957

(2009) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutinin of Influenza A Viruses

(2009) Reiko Yoshida et al.   PLoS Pathogens

Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol

(2008) Irina A. Leneva et al.   ANTIVIRAL RESEARCH

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

(2008) R. J. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies

(2008) A. K. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA