Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations

NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy

(2019) Yakubu Princely Abudu et al.   DEVELOPMENTAL CELL

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

(2019) Elise Fouquerel et al.   MOLECULAR CELL

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice

(2018) Kirsty Foote et al.   AGING CELL

Ketogenic diet in cancer therapy

(2018) Daniela D. Weber et al.   Aging-US

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals

(2018) Lakshmi Narayanan Lakshmanan et al.   AGING CELL

The Impact of Mitochondrial and Nuclear DNA Variants on Late-Onset Alzheimer's Disease Risk

(2018) Aleksandra Maruszak et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial DNA Sequence Variation Associated with Dementia and Cognitive Function in the Elderly

(2018) Gregory J. Tranah et al.   JOURNAL OF ALZHEIMERS DISEASE

Biallelic mutations in FDXR cause neurodegeneration associated with inflammation

(2018) Jesse Slone et al.   JOURNAL OF HUMAN GENETICS

Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells

(2018) Ksenia N. Morozova et al.   PLoS One

An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle

(2017) Jan Niemann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease

(2017) Kahori Shiba-Fukushima et al.   HUMAN MOLECULAR GENETICS

Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism

(2017) Lanying Song et al.   NEUROBIOLOGY OF DISEASE

Huntington’s Disease and Mitochondria

(2017) Mohammad Jodeiri Farshbaf et al.   NEUROTOXICITY RESEARCH

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes

(2017) María Gómez-Serrano et al.   Redox Biology

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs

(2016) Eunju Kang et al.   Cell Stem Cell

Mitochondrial DNA variants as genetic risk factors for Parkinson disease

(2016) C. W. Liou et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress

(2016) Hezhongrong Nie et al.   MITOCHONDRION

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Somatic mtDNA variation is an important component of Parkinson's disease

(2016) Jonathan Coxhead et al.   NEUROBIOLOGY OF AGING

Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging

(2016) Johannes Friedrich Georg Neuhaus et al.   NEUROENDOCRINOLOGY

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Mitochondrial DNA copy number variation across human cancers

(2016) Ed Reznik et al.   eLife

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease

(2015) Jeong-A Lim et al.   Autophagy

Mitochondria apoptosis pathway synergistically activated by hierarchical targeted nanoparticles co-delivering siRNA and lonidamine

(2015) Bing-Feng Zhang et al.   BIOMATERIALS

The Evolving Understanding of the Contribution of Lipid Metabolism to Diabetic Kidney Disease

(2015) Krisztian Stadler et al.   Current Diabetes Reports

Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure

(2015) Yong Kyung Kim et al.   DIABETOLOGIA

15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma–paraganglioma syndromes characterized by germlineSDHBandSDHDmutations

(2015) Bora E Baysal et al.   ENDOCRINE-RELATED CANCER

Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice

(2015) Jonathan Wanagat et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

(2015) Natalia P. Mena et al.   MITOCHONDRION

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

(2015) Chris Cadonic et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese

(2015) Rui Bi et al.   NEUROBIOLOGY OF AGING

PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

(2015) B Khalil et al.   Cell Death & Disease

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Maternally inherited diabetes and deafness (MIDD): Diagnosis and management

(2014) Aye Naing et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Usage of mitochondrial D-loop variation to predict risk for Huntington disease

(2014) Kazem Mousavizadeh et al.   Mitochondrial DNA

Glucose metabolism derangements in adults with the MELAS m.3243A>G mutation

(2014) Ayman W. El-Hattab et al.   MITOCHONDRION

Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease

(2014) Maria Hvidberg Petersen et al.   MITOCHONDRION

Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes

(2014) Joungil Choi et al.   MITOCHONDRION

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

(2014) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Control of mitochondrial integrity in ageing and disease

(2014) R. Szklarczyk et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

(2014) Young Seok Ju et al.   eLife

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

A compound heterozygous mutation in HADHB gene causes an axonal Charcot-Marie-tooth disease

(2013) Young Bin Hong et al.   BMC Medical Genetics

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease

(2013) G. Hudson et al.   NEUROLOGY

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Is mitochondrial DNA turnover slower than commonly assumed?

(2012) Suresh Kumar Poovathingal et al.   BIOGERONTOLOGY

Classic and New Animal Models of Parkinson's Disease

(2012) Javier Blesa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

(2012) Richard D. W. Kelly et al.   NUCLEIC ACIDS RESEARCH

The replication rate of human hematopoietic stem cells in vivo

(2011) S. N. Catlin et al.   BLOOD

Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer

(2011) J. Guo et al.   CANCER RESEARCH

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

(2011) U. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy

(2011) Eliecer Coto et al.   NEUROGENETICS

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

(2010) Aurelia Santoro et al.   PLoS One

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology

(2009) A. Grünewald et al.   EXPERIMENTAL NEUROLOGY

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes

(2009) Antonio Zorzano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial DNA variants in a Japanese population of patients with Alzheimer’s disease

(2009) Noriko Tanaka et al.   MITOCHONDRION

Clinical and molecular aspects of Japanese patients with mitochondrial trifunctional protein deficiency

(2009) Jamiyan Purevsuren et al.   MOLECULAR GENETICS AND METABOLISM

Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells

(2009) Matthew E. Gegg et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of tRNALeu/Lys and ATPase 6 Genes Mutations in Huntington’s Disease

(2008) Sadaf Kasraie et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community

(2008) Prachi Mehta et al.   MOVEMENT DISORDERS

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA