Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma

Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma

(2019) Nicola Amodio et al.   Cancers

HDAC Inhibitors Exert Anti-Myeloma Effects through Multiple Modes of Action

(2019) Yoichi Imai et al.   Cancers

Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-mir-17-92

(2018) Eugenio Morelli et al.   BLOOD

Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

(2018) Stephen Safe et al.   Cancer Prevention Research

Impact of natural dietary agents on multiple myeloma prevention and treatment: molecular insights and potential for clinical translation

(2018) Lavinia Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

Simple and efficient sustainable semi-synthesis of oleacein [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] as potential additive for edible oils

(2018) Paola Costanzo et al.   FOOD CHEMISTRY

shRNA targeting of ferritin heavy chain activates H19/miR-675 axis in K562 cells

(2018) M. Di Sanzo et al.   GENE

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity

(2018) Nicola Amodio et al.   LEUKEMIA

Aging and nutrition induce tissue-specific changes on global DNA methylation status in rats

(2018) Francesco Guarasci et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Evaluation of total phenolic fraction derived from extra virgin olive oil for its antileishmanial activity

(2018) Olga S. Koutsoni et al.   PHYTOMEDICINE

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy

(2018) Amit Singh et al.   Nutrients

Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice

(2018) Giovanni Enrico Lombardo et al.   Frontiers in Endocrinology

miR-22 suppresses DNA ligase III addiction in multiple myeloma

(2018) Daniele Caracciolo et al.   LEUKEMIA

An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs

(2018) Deyu Huang et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective

(2018) Fernanda I. Saldívar-González et al.   Frontiers in Pharmacology

Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma

(2017) Maria Angelica Stamato et al.   Oncotarget

MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop

(2017) Shu-Sen Xia et al.   Oncotarget

Progress and Paradigms in Multiple Myeloma

(2016) Kenneth C. Anderson   CLINICAL CANCER RESEARCH

Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation

(2016) Nicola Amodio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

(2016) Nicola Amodio et al.   MOLECULAR CANCER THERAPEUTICS

Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells

(2016) Stefano Fogli et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth

(2016) M Fulciniti et al.   Blood Cancer Journal

MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment

(2016) Lavinia Raimondi et al.   Biomed Research International

Natural compounds: Role in reversal of epigenetic changes

(2015) Ruchi Aggarwal et al.   BIOCHEMISTRY-MOSCOW

A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells

(2015) A. Gulla et al.   CLINICAL CANCER RESEARCH

Oleacein. Translation from Mediterranean Diet to Potential Antiatherosclerotic Drug

(2015) Marek Naruszewicz et al.   CURRENT PHARMACEUTICAL DESIGN

FDA Approves New Agent for Multiple Myeloma

(2015) M. P. Fenichel   JNCI-Journal of the National Cancer Institute

Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo

(2015) E Morelli et al.   LEUKEMIA

Oleacein enhances anti-inflammatory activity of human macrophages by increasing CD163 receptor expression

(2015) Agnieszka Filipek et al.   PHYTOMEDICINE

Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies

(2015) Mohammad A. Khanfar et al.   PHYTOTHERAPY RESEARCH

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients

(2015) Enrica Calura et al.   Oncotarget

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

(2015) Maria Rita Pitari et al.   Oncotarget

miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies

(2015) Nicola Amodio et al.   Oncotarget

FDA Approves New Agent for Multiple Myeloma

(2015) M. P. Fenichel   JNCI-Journal of the National Cancer Institute

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma

(2015) Nicola Amodio et al.   Oncotarget

Components of a standardised olive leaf dry extract (Ph. Eur.) promote hypothiocyanite production by lactoperoxidase

(2014) Jörg Flemmig et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MYD88-independent growth and survival effects of Sp1 transactivation in Waldenstrom macroglobulinemia

(2014) M. Fulciniti et al.   BLOOD

MicroRNA and Multiple Myeloma: from Laboratory Findings to Translational Therapeutic Approaches

(2014) Marco Rossi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells

(2014) Mohamed R. Akl et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biomimetic synthesis and antioxidant evaluation of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate]

(2014) Monica Nardi et al.   FOOD CHEMISTRY

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

(2014) Barbara Barbaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A p53-Dependent Tumor Suppressor Network Is Induced by Selective miR-125a-5p Inhibition in Multiple Myeloma Cells

(2014) Marzia Leotta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

(2014) Stefania Bulotta et al.   Journal of Translational Medicine

Oleocanthal Inhibits Proliferation and MIP-1α Expression in Human Multiple Myeloma Cells

(2013) M. Scotece et al.   CURRENT MEDICINAL CHEMISTRY

Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma

(2013) Nicola Amodio et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

New Insights into the Treatment of Multiple Myeloma with Histone Deacetylase Inhibitors

(2012) Michele Cea et al.   CURRENT PHARMACEUTICAL DESIGN

miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1

(2012) N Amodio et al.   Cell Death & Disease

Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma

(2010) J. Kikuchi et al.   BLOOD

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Synthesis, Biological Evaluation, and Molecular Modeling of Oleuropein and Its Semisynthetic Derivatives as Cyclooxygenase Inhibitors

(2009) Antonio Procopio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY