Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus

(2019) Daniella Buonfiglio et al.   JOURNAL OF PINEAL RESEARCH

Melatonin increases brown adipose tissue mass and function in Zücker diabetic fatty rats: implications for obesity control

(2018) Gumersindo Fernández Vázquez et al.   JOURNAL OF PINEAL RESEARCH

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity

(2018) Sharon Owino et al.   JOURNAL OF PINEAL RESEARCH

Short photoperiod reverses obesity in Siberian hamsters via sympathetically induced lipolysis and Browning in adipose tissue

(2018) Vitaly Ryu et al.   PHYSIOLOGY & BEHAVIOR

Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats

(2018) Daniella Buonfiglio et al.   Frontiers in Endocrinology

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

(2018) Angeliki Karamitri et al.   Science Signaling

Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function

(2018) Kaiqing Liu et al.   JOURNAL OF LIPID RESEARCH

Melatonin in type 2 diabetes mellitus and obesity

(2018) Angeliki Karamitri et al.   Nature Reviews Endocrinology

Circadian clocks and insulin resistance

(2018) Dirk Jan Stenvers et al.   Nature Reviews Endocrinology

MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes

(2017) Maciej Tarnowski et al.   GYNECOLOGICAL ENDOCRINOLOGY

Melatonin prevents obesity through modulation of gut microbiota in mice

(2017) Pengfei Xu et al.   JOURNAL OF PINEAL RESEARCH

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development

(2017) Klara Rosta et al.   PLoS One

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

(2016) Tiinamaija Tuomi et al.   Cell Metabolism

Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank

(2016) Wei Gan et al.   DIABETOLOGIA

Melatonin Receptor 1 Deficiency Affects Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice

(2016) Claudia Fischer et al.   NEUROENDOCRINOLOGY

Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis

(2016) Ling Wu et al.   Scientific Reports

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks

(2016) Sharon Owino et al.   PLoS One

Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial

(2015) Anne Kristine Amstrup et al.   CLINICAL ENDOCRINOLOGY

Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese

(2015) X. Song et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

New insights in leptin resistance mechanisms in mice

(2015) Eglantine Balland et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Melatonin reduces obesity and restores adipokine patterns and metabolism in obese ( ob/ob ) mice

(2015) Gaia Favero et al.   NUTRITION RESEARCH

Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters

(2015) Ibtissam Chakir et al.   Frontiers in Neuroscience

Melatonin, energy metabolism, and obesity: a review

(2014) J. Cipolla-Neto et al.   JOURNAL OF PINEAL RESEARCH

Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats

(2013) Juliana A. Faria et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women

(2013) Chao Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Melatonin Secretion and the Incidence of Type 2 Diabetes

(2013) Ciaran J. McMullan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

(2013) Aroa Jiménez-Aranda et al.   JOURNAL OF PINEAL RESEARCH

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

(2013) Kenneth A. Dyar et al.   Molecular Metabolism

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Obesity in mice with adipocyte-specific deletion of clock component Arntl

(2012) Georgios K Paschos et al.   NATURE MEDICINE

Absence of Melatonin Induces Night-Time Hepatic Insulin Resistance and Increased Gluconeogenesis Due to Stimulation of Nocturnal Unfolded Protein Response

(2011) Tatiane C. Nogueira et al.   ENDOCRINOLOGY

Melatonin Receptor 1A Gene Polymorphism Associated with Polycystic Ovary Syndrome

(2011) Chao Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity

(2011) L.F. Been et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

(2010) E. A. Andersson et al.   DIABETES

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse

(2010) Susana Contreras-Alcantara et al.   Obesity

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

(2010) D.-X. Tan et al.   Obesity Reviews

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

(2009) T. Sparso et al.   DIABETES

Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism

(2009) Y. Macotela et al.   DIABETES

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice

(2009) Claudio Sartori et al.   ENDOCRINOLOGY

Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose

(2009) Eckhard Mühlbauer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gender differences in insulin resistance, body composition, and energy balance

(2009) Eliza B. Geer et al.   Gender Medicine

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA