Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

HIV-exposed uninfected infants have increased inflammation and monocyte activation

(2019) Sahera Dirajlal-Fargo et al.   AIDS

The interleukin 21 (IL 21)/ microRNA-29 (miR-29) axis is associated with natural resistance to HIV-1 infection

(2018) Paula Andrea Serna Ortega et al.   AIDS

Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation

(2018) Yoshikuni Goto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Integrated analysis of fine-needle-aspiration cystic fluid proteome, cancer cell secretome, and public transcriptome datasets for papillary thyroid cancer biomarker discovery

(2018) Chia-Chun Wu et al.   Oncotarget

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

(2018) Chun Jimmie Ye et al.   GENOME RESEARCH

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

(2018) Aimee L. Hanson et al.   HUMAN IMMUNOLOGY

Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease

(2018) José A. López de Castro et al.   HUMAN IMMUNOLOGY

Genetic and immune determinants of immune activation in HIV-exposed seronegative individuals and their role in protection against HIV infection

(2017) Claudio Fenizia et al.   INFECTION GENETICS AND EVOLUTION

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome

(2017) Adrian Martín-Esteban et al.   JOURNAL OF AUTOIMMUNITY

Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells

(2017) I-Chun Kuo et al.   Oncotarget

High Expression of Antiviral and Vitamin D Pathway Genes Are a Natural Characteristic of a Small Cohort of HIV-1-Exposed Seronegative Individuals

(2017) Wbeimar Aguilar-Jimenez et al.   Frontiers in Immunology

Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation

(2016) Irma Saulle et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Stimulation of PBMC and Monocyte-Derived Macrophages via Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy

(2016) Esther Merlini et al.   Frontiers in Immunology

ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

Innate Activation of MDC and NK Cells in High-Risk HIV-1–Exposed Seronegative IV-Drug Users Who Share Needles When Compared With Low-Risk Nonsharing IV-Drug User Controls

(2015) Costin Tomescu et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages

(2015) Y. Goto et al.   JOURNAL OF BIOCHEMISTRY

ERp44 Exerts Redox-Dependent Control of Blood Pressure at the ER

(2015) Chihiro Hisatsune et al.   MOLECULAR CELL

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

(2014) Jonas J.W. Kuiper et al.   HUMAN MOLECULAR GENETICS

TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages

(2014) Y. Goto et al.   JOURNAL OF IMMUNOLOGY

HLA-B27, but Not HLA-B7, Immunodominance to Influenza Is ERAP Dependent

(2014) A. Akram et al.   JOURNAL OF IMMUNOLOGY

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency

(2014) Irini Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Evolutionary Analysis Identifies an MX2 Haplotype Associated with Natural Resistance to HIV-1 Infection

(2014) Manuela Sironi et al.   MOLECULAR BIOLOGY AND EVOLUTION

An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection

(2014) Diego Forni et al.   PLoS Genetics

Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection

(2013) Mara Biasin et al.   AIDS

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies

(2013) Efstratios Stratikos et al.   MOLECULAR IMMUNOLOGY

Peptidases trimming MHC class I ligands

(2012) Mirjana Weimershaus et al.   CURRENT OPINION IN IMMUNOLOGY

Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

(2012) Loredana Cifaldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

The descent of memory T cells

(2011) Carmen Gerlach et al.   Annals of the New York Academy of Sciences

Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ

(2011) Yoshikuni Goto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection

(2010) R. Cagliani et al.   HUMAN MOLECULAR GENETICS

TLR Activation Pathways in HIV-1–Exposed Seronegative Individuals

(2010) Mara Biasin et al.   JOURNAL OF IMMUNOLOGY