Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

Tight Turns of Outer Membrane Proteins: An Analysis of Sequence, Structure, and Hydrogen Bonding

(2018) Meghan Whitney Franklin et al.   JOURNAL OF MOLECULAR BIOLOGY

Monoclonal antibody targeting the β-barrel assembly machine ofEscherichia coliis bactericidal

(2018) Kelly M. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies

(2018) Rajesh Vij et al.   Scientific Reports

Structural basis for dual-mode inhibition of the ABC transporter MsbA

(2018) Hoangdung Ho et al.   NATURE

Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility

(2018) Nicolò Paracini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Escherichia coli β-Barrel Assembly Machinery Is Sensitized to Perturbations under High Membrane Fluidity

(2018) Kelly M. Storek et al.   JOURNAL OF BACTERIOLOGY

Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli

(2018) Stefan U. Vetterli et al.   Science Advances

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

(2017) Andrii Ishchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another

(2017) Yasmina Noubia Abdiche et al.   PLoS One

Distinct antibody species: structural differences creating therapeutic opportunities

(2016) Serge Muyldermans et al.   CURRENT OPINION IN IMMUNOLOGY

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

(2016) Suguru Okuda et al.   NATURE REVIEWS MICROBIOLOGY

Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens

(2016) Istvan Botos et al.   STRUCTURE

LptD is a promising vaccine antigen and potential immunotherapeutic target for protection against Vibrio species infection

(2016) Zhenzhong Zha et al.   Scientific Reports

Outer membrane protein biogenesis in Gram-negative bacteria

(2015) Sarah E. Rollauer et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lipopolysaccharide is Inserted into the Outer Membrane through An Intramembrane Hole, A Lumen Gate, and the Lateral Opening of LptD

(2015) Yinghong Gu et al.   STRUCTURE

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

(2015) Phillip J. Stansfeld et al.   STRUCTURE

Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane

(2015) Xuejun Li et al.   Scientific Reports

Biosynthesis and Export of Bacterial Lipopolysaccharides

(2014) Chris Whitfield et al.   Annual Review of Biochemistry

Structural basis for outer membrane lipopolysaccharide insertion

(2014) Haohao Dong et al.   NATURE

Structural basis for lipopolysaccharide insertion in the bacterial outer membrane

(2014) Shuai Qiao et al.   NATURE

Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire

(2014) Jason J. Lavinder et al.   PLoS One

Antibody and Antigen Contact Residues Define Epitope and Paratope Size and Structure

(2013) J. W. Stave et al.   JOURNAL OF IMMUNOLOGY

An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins

(2013) Meredith Hazen et al.   mAbs

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Mutational and Topological Analysis of the Escherichia coli BamA Protein

(2013) Douglas F. Browning et al.   PLoS One

Conformation-specific labeling of BamA and suppressor analysis suggest a cyclic mechanism for  -barrel assembly in Escherichia coli

(2013) N. W. Rigel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli

(2012) S. Okuda et al.   SCIENCE

The Bam machine: A molecular cooper

(2011) Dante P. Ricci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Defining Function of Lipopolysaccharide O-antigen Ligase WaaL Using Chemoenzymatically Synthesized Substrates

(2011) Weiqing Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoprotein LptE is required for the assembly of LptD by the  -barrel assembly machine in the outer membrane of Escherichia coli

(2011) G. Chimalakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel

(2011) E. Freinkman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Escherichia coliK-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases

(2009) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered cell surface expression of membrane immunoglobulin as a means to identify monoclonal antibody-secreting hybridomas

(2009) Paul W. Price et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The bactericidal effect of a complement-independent antibody is osmolytic and specific to Borrelia

(2009) T. J. LaRocca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

(2008) N. Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA