PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

Proinsulin misfolding is an early event in the progression to type 2 diabetes

(2019) Anoop Arunagiri et al.   eLife

Eat it right: ER-phagy and recovER-phagy

(2018) Marisa Loi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor

(2018) Kyle S. Cole et al.   BIOCHEMISTRY

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

Biosynthesis, structure, and folding of the insulin precursor protein

(2018) Ming Liu et al.   DIABETES OBESITY & METABOLISM

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

(2018) Yael Riahi et al.   eLife

Metabolic Stress and Compromised Identity of Pancreatic Beta Cells

(2017) Avital Swisa et al.   Frontiers in Genetics

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine

(2016) Nabodita Kaul et al.   DNA AND CELL BIOLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

(2015) Jaeseok Han et al.   DIABETES

Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone

(2015) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative protein folding: From thiol–disulfide exchange reactions to the redox poise of the endoplasmic reticulum

(2015) Devin A. Hudson et al.   FREE RADICAL BIOLOGY AND MEDICINE

ERdj5 Reductase Cooperates with Protein Disulfide Isomerase To Promote Simian Virus 40 Endoplasmic Reticulum Membrane Translocation

(2015) Takamasa Inoue et al.   JOURNAL OF VIROLOGY

Natural history of β-cell adaptation and failure in type 2 diabetes

(2015) Emilyn U. Alejandro et al.   MOLECULAR ASPECTS OF MEDICINE

PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis

(2015) Kaiyu He et al.   MOLECULAR BIOLOGY OF THE CELL

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

(2013) K. Kim et al.   BLOOD

Extracellular protein disulfide isomerase regulates ligand-binding activity of  M 2 integrin and neutrophil recruitment during vascular inflammation

(2013) E. Hahm et al.   BLOOD

Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress

(2013) Jordan Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

The Physiological Functions of Mammalian Endoplasmic Oxidoreductin 1: On Disulfides and More

(2012) Thomas Ramming et al.   ANTIOXIDANTS & REDOX SIGNALING

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

(2012) Shiyu Wang et al.   Cell Metabolism

Disulfide Bond Formation in the Mammalian Endoplasmic Reticulum

(2012) N. J. Bulleid   Cold Spring Harbor Perspectives in Biology

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

The Protein Disulfide Isomerase Family: Key Players in Health and Disease

(2011) Adam M. Benham   ANTIOXIDANTS & REDOX SIGNALING

Action of Protein Disulfide Isomerase on Proinsulin Exit from Endoplasmic Reticulum of Pancreatic β-Cells

(2011) Gautam Rajpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulfide isomerase isomerizes non-native disulfide bonds in human proinsulin independent of its peptide-binding activity

(2011) Jeannette Winter et al.   PROTEIN SCIENCE

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

(2010) Gabriel Loor et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins

(2009) C. E. Jessop et al.   JOURNAL OF CELL SCIENCE

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

(2008) Carlo Colombo et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide models of four possible insulin folding intermediates with two disulfides

(2003) Xiao-Yuan Jia et al.   PROTEIN SCIENCE