Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

Regenerative proliferation of differentiated cells by mTORC1‐dependent paligenosis

(2018) Spencer G Willet et al.   EMBO JOURNAL

De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver

(2018) Liping Luo et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Raptor regulates functional maturation of murine beta cells

(2017) Qicheng Ni et al.   Nature Communications

Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1

(2017) Prasun Guha et al.   Oncotarget

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

The Genetic Program of Pancreatic β-Cell Replication In Vivo

(2016) Agnes Klochendler et al.   DIABETES

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

(2016) Soren K. Thomsen et al.   DIABETES

Stress-induced adaptive islet cell identity changes

(2016) V. Cigliola et al.   DIABETES OBESITY & METABOLISM

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

(2016) Ting Yuan et al.   DIABETOLOGIA

Dynamic development of the pancreas from birth to adulthood

(2016) Susan Bonner-Weir et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

S6K1 controls pancreatic β cell size independently of intrauterine growth restriction

(2015) Sung Hee Um et al.   JOURNAL OF CLINICAL INVESTIGATION

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

Maternal diet–induced microRNAs and mTOR underlie β cell dysfunction in offspring

(2014) Emilyn U. Alejandro et al.   JOURNAL OF CLINICAL INVESTIGATION

p85  deficiency protects  -cells from endoplasmic reticulum stress-induced apoptosis

(2014) J. N. Winnay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nkx6.1 regulates islet  -cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

(2014) J. S. Tessem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Central Role for GRB10 in Regulation of Islet Function in Man

(2014) Inga Prokopenko et al.   PLoS Genetics

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes

(2013) Ionel Sandovici et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diabetes mellitus due to the toxic misfolding of proinsulin variants

(2013) Michael A. Weiss   FEBS LETTERS

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

Disruption of Growth Factor Receptor-Binding Protein 10 in the Pancreas Enhances  -Cell Proliferation and Protects Mice From Streptozotocin-Induced  -Cell Apoptosis

(2012) J. Zhang et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Postnatal Development of Numbers and Mean Sizes of Pancreatic Islets and Beta-Cells in Healthy Mice and GIPRdn Transgenic Diabetic Mice

(2011) Nadja Herbach et al.   PLoS One

Impairment of Rat Fetal Beta-Cell Development by Maternal Exposure to Dexamethasone during Different Time-Windows

(2011) Olivier Dumortier et al.   PLoS One

What ails the β-cell?

(2010) D. Accili et al.   DIABETES OBESITY & METABOLISM

Experimental Intrauterine Growth Restriction Induces Alterations in DNA Methylation and Gene Expression in Pancreatic Islets of Rats

(2010) Reid F. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

EGF receptor in pancreatic β-cell mass regulation

(2008) Päivi Miettinen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY