Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
出版年份 2019 全文链接
标题
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
作者
关键词
Apabetalone, Bromodomain, BRD4, Epigenetics, THP-1 monocytes, HUVEC, endothelium, Adhesion, Atherosclerosis, CVD, Diabetes, Vascular inflammation
出版物
Clinical Epigenetics
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-12
DOI
10.1186/s13148-019-0696-z
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Apabetalone Mediated Epigenetic Modulation is Associated with Favorable Kidney Function and Alkaline Phosphatase Profile in Patients with Chronic Kidney Disease
- (2018) Ewelina Kulikowski et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
- (2018) Amir Tajbakhsh et al. PHARMACOLOGY & THERAPEUTICS
- The Effect of Bromodomain and Extra-Terminal Inhibitor Apabetalone on Attenuated Coronary Atherosclerotic Plaque: Insights from the ASSURE Trial
- (2018) Daisuke Shishikura et al. American Journal of Cardiovascular Drugs
- Atherosclerosis and immunity: a perspective
- (2018) Fereshte Abdolmaleki et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Endothelial cell-cell adhesion and signaling
- (2017) Camilla Cerutti et al. EXPERIMENTAL CELL RESEARCH
- Mechanisms of foam cell formation in atherosclerosis
- (2017) Dimitry A. Chistiakov et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Roles of Cells from the Arterial Vessel Wall in Atherosclerosis
- (2017) Di Wang et al. MEDIATORS OF INFLAMMATION
- Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)
- (2017) Sylwia Wasiak et al. Journal of Cardiovascular Translational Research
- Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
- (2017) Sadhan Das et al. Nature Communications
- Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives
- (2017) Christodoulos Stefanadis et al. Journal of the American Heart Association
- The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation
- (2016) Mingcheng Huang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
- (2016) Michael A. Gimbrone et al. CIRCULATION RESEARCH
- Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE −/− mice
- (2016) Qiong Duan et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage
- (2016) Irina Ushach et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial
- (2015) Stephen J. Nicholls et al. American Journal of Cardiovascular Drugs
- Selectins: initiators of leucocyte adhesion and signalling at the vascular wall
- (2015) Rodger P. McEver CARDIOVASCULAR RESEARCH
- Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
- (2015) Dipak P. Ramji et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Tissue Factor and Atherothrombosis
- (2015) Kohei Tatsumi et al. Journal of Atherosclerosis and Thrombosis
- A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice
- (2014) Ravi Jahagirdar et al. ATHEROSCLEROSIS
- Association of interleukin 8 with myocardial infarction: Results from the Stockholm Heart Epidemiology Program
- (2014) Ilais Moreno Velásquez et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis
- (2014) Jonathan D. Brown et al. MOLECULAR CELL
- Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
- (2014) Friederike Itzen et al. NUCLEIC ACIDS RESEARCH
- RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist
- (2014) Kevin G. McLure et al. PLoS One
- Toll-Like Receptors in Atherosclerosis
- (2013) Mika Falck-Hansen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- LOX-1, OxLDL, and Atherosclerosis
- (2013) Angela Pirillo et al. MEDIATORS OF INFLAMMATION
- RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
- (2013) S. Picaud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Getting Leukocytes to the Site of Inflammation
- (2013) W. A. Muller VETERINARY PATHOLOGY
- Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice
- (2012) Jong-Gil Park et al. ATHEROSCLEROSIS
- ApoA-I Induction as a Potential Cardioprotective Strategy: Rationale for the SUSTAIN and ASSURE Studies
- (2012) Stephen J. Nicholls et al. CARDIOVASCULAR DRUGS AND THERAPY
- Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction
- (2012) Bo Shen et al. CURRENT OPINION IN CELL BIOLOGY
- The bromodomain interaction module
- (2012) Panagis Filippakopoulos et al. FEBS LETTERS
- Place your BETs: the therapeutic potential of bromodomains
- (2012) R.K. Prinjha et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Methicillin resistant Staphylococcus aureus adhesion to human umbilical vein endothelial cells demonstrates wall shear stress dependent behaviour
- (2011) Kayla D Viegas et al. Biomedical Engineering Online
- Efficacy and Safety of a Novel Oral Inducer of Apolipoprotein A-I Synthesis in Statin-Treated Patients With Stable Coronary Artery Disease
- (2011) Stephen J. Nicholls et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- NF-κB is 25
- (2011) David Baltimore NATURE IMMUNOLOGY
- Anti-inflammatory therapeutics for the treatment of atherosclerosis
- (2011) Israel F. Charo et al. NATURE REVIEWS DRUG DISCOVERY
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Interleukin 8 and cardiovascular disease
- (2009) S. Apostolakis et al. CARDIOVASCULAR RESEARCH
- Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
- (2009) Satish L. Deshmane et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis
- (2009) Javier Mestas et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA
- (2008) B. Huang et al. MOLECULAR AND CELLULAR BIOLOGY
- The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription
- (2008) Gary LeRoy et al. MOLECULAR CELL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started