Editorial Material
Biology
Hovy Ho-Wai Wong, Christina You Chien Chou, Alanna Jean Watt, Per Jesper Sjoestroem
Summary: This statement points out that inhibitory circuit motifs in the mouse brain and the human brain are remarkably similar.
Article
Immunology
Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis, Adib Zendedel
Summary: This study suggests that activation of Nrf2 in astrocytes protects against spinal cord injury by reducing oxidative damage and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Run Zhang, Biao Xu, Nan Zhang, Jiandong Niu, Mengna Zhang, Qinqin Zhang, Dan Chen, Yonghang Shi, Danni Chen, Kedi Liu, Xiaodi Zhang, Ning Li, Quan Fang
Summary: This study investigates the non-neuronal mechanisms involved in burn injury-induced pain (BIP) at the spinal cord level using a mouse model. The researchers found that both microglia and astrocytes are activated in response to burn injury, and the cytokines TNF and CXCL1 play important roles in pain hypersensitivity. The study suggests that targeting glial pathways could be a promising strategy for managing BIP.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Anatomy & Morphology
Safiye Cavdar, Busra Kose, Ilknur Sur-Erdem, Mazhar Ozkan
Summary: The study found a significant increase in protein expression of astrocytic gap junction proteins Cx30 and Cx43 in genetically absence epileptic animal models, indicating a potential involvement of astrocytic connexins in the mechanism of absence epilepsy. This increased expression may represent a compensatory response of the thalamocortical circuitry to absence seizures or could be related to the production and/or development of absence seizures.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Cell Biology
Linda Melzer, Thomas M. Freiman, Amin Derouiche
Summary: Astrocytes play a significant role in higher brain functions, and their TGN (trans-Golgi network) contains a substantial amount of Rab6A immunostaining, suggesting it as a global descriptor of astrocyte identity. Rab6A is associated with GFAP(+) astrocytes in both mouse and human brains, exhibiting clear cell type-specificity.
Article
Chemistry, Multidisciplinary
An-Qi Dong, Ya-Ping Yang, Shu-Min Jiang, Xiao-Yu Yao, Di Qi, Cheng-Jie Mao, Xiao-Yu Cheng, Fen Wang, Li-Fang Hu, Chun-Feng Liu
Summary: This study demonstrates the anti-neuroinflammatory activity of PPX through enhancing autophagy activity in astrocytes, which provides a new mechanism for the beneficial effect of PPX in Parkinson's disease therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Nadia Rosenberg, Maria Reva, Francesca Binda, Leonardo Restivo, Pauline Depierre, Julien Puyal, Marc Briquet, Yann Bernardinelli, Anne-Berengere Rocher, Henry Markram, Jean-Yves Chatton
Summary: Recent research suggests that targeting astrocytes and their mitochondria could be an effective strategy to prevent early-stage Alzheimer's disease, as it can prevent metabolic abnormalities, hippocampal atrophy, and cognitive decline.
Article
Neurosciences
Carmen Falcone, Elisa Penna, Tiffany Hong, Alice F. Tarantal, Patrick R. Hof, William D. Hopkins, Chet C. Sherwood, Stephen C. Noctor, Veronica Martinez-Cerdeno
Summary: Interlaminar astrocytes (ILAs) are a unique subset of cortical astrocytes found in layer I, originating likely from radial glial (RG) cells, proliferating locally during gestation, and extending interlaminar processes postnatally. Studies on three primate species and mice revealed that ILAs exhibit increased density and morphological complexity with age, express multiple markers including RG and astrocyte markers, and show differences between primate species and mice. These findings suggest a lineal relationship between RG cells and ILAs.
Article
Biochemistry & Molecular Biology
Jose Luis Trillo-Contreras, Juan Jose Toledo-Aral, Javier Villadiego, Miriam Echevarria
Summary: Aquaporin-4 (AQP4) is the principal water channel in the brain, playing a crucial role in cerebrospinal fluid (CSF) homeostasis and hydrocephalus. The study found that alterations associated with hydrocephalic state may not be permanent, as some symptoms can be reversed by reexposure to normoxia, but deficits in CSF outflow and ventricular distensibility persist.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu, Jiaqi Liu, Jianhua Ding, Ming Lu, Gang Hu
Summary: Fluoxetine inhibits the activation of A1 reactive astrocyte through the 5-HT2BR/P-arrestin pathway, showing promising therapeutic effects in a mouse model of MDD.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Immunology
Miao-Miao Chen, Zhao-Li Hu, Jian-Hua Ding, Ren-Hong Du, Gang Hu
Summary: The study suggests that the astrocytic Kir6.1/K-ATP channel plays a role in preventing neurodegeneration in PD by facilitating astrocyte-neuron communication through NF-KB/C3/C3aR signaling. Targeting astroglial Kir6.1/K-ATP channel-NF-kappa B-C3-neuronal C3aR signaling could be a novel therapeutic strategy for PD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Geriatrics & Gerontology
Wenyue Cao, Junbin Lin, Wei Xiang, Jingying Liu, Biru Wang, Weijing Liao, Ting Jiang
Summary: This study investigated the effects of physical exercise on cognitive impairment induced by chronic cerebral hypoperfusion (CCH) in rats. The results showed that physical exercise improved cognitive function, reduced neurotoxic astrocytes, promoted neuroprotective astrocytes, and enhanced primary ciliogenesis. Physical exercise may improve cognitive function by activating the ERK and JNK signaling pathways.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Barbara Witt, Michael Stiboller, Stefanie Raschke, Sharleen Friese, Franziska Ebert, Tanja Schwerdtle
Summary: Copper, an essential trace element, can lead to adverse effects when present in excess levels. This study investigated the toxic potential of copper on human astrocytic cell models, showing substantial cytotoxic effects and disruption of mitochondrial function. Additionally, excess copper also affected the balance of other essential elements like calcium, iron, and manganese, which may contribute to oxidative stress and neurodegenerative disorders.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Romain Tortuyaux, Katia Avila-Gutierrez, Marc Oudart, Noemie Mazare, Philippe Mailly, Jean-Christophe Deschemin, Sophie Vaulont, Carole Escartin, Martine Cohen-Salmon
Summary: Astrocytes play a crucial role in brain iron homeostasis, and the regulation of ferritin mRNA density and distribution in astrocytes contribute to iron homeostasis in physiology and pathophysiology.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Zengli Zhang, Zhi Ma, Wangyuan Zou, Lixia Zhang, Yan Li, Jian Zhang, Min Liu, Wugang Hou, Yulong Ma
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Behavioral Sciences
Liang Tao, Yuanyuan Zhu, Rui Wang, Jiao Han, Yulong Ma, Hang Guo, Wenhong Tang, Lixia Zhuo, Ze Fan, Anqi Yin, Wugang Hou, Yan Li
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neurosciences
Hang Guo, Jingrun Yang, Min Liu, Long Wang, Wugang Hou, Lixia Zhang, Yulong Ma
Article
Hematology
Kaiyuan Li, Huitao Wu, Fei Pan, Li Chen, Cong Feng, Yihao Liu, Hui Hui, Xiaoyu Cai, Hebin Che, Yulong Ma, Tanshi Li
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2020)
Review
Neurosciences
Hang Guo, Min Liu, Lixia Zhang, Long Wang, Wugang Hou, Yaqun Ma, Yulong Ma
CURRENT NEUROPHARMACOLOGY
(2020)
Article
Anesthesiology
E. Wang, Wei Mei, You Shang, Changsheng Zhang, Lujia Yang, Yulong Ma, Yan Chen, Jiapeng Huang, Tao Zhu, Weidong Mi
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2020)
Article
Neurosciences
Hang Guo, Anqi Yin, Yulong Ma, Ze Fan, Liang Tao, Wenhong Tang, Yaqun Ma, Wugang Hou, Guohong Cai, Lixia Zhuo, Jian Zhang, Yan Li, Lize Xiong
Summary: The lack of NDRG2 leads to severe brain edema and astrocyte swelling, but alleviation can be achieved by restoring the expression of Na+-K+-ATPase beta 1. Upregulation of NDRG2 by lentiviral constructs protects the brain from ischemic edema.
Article
Neurosciences
Yulong Ma, Min Liu, Lifang Yang, Lixia Zhang, Hang Guo, Wugang Hou, Pei Qin
MOLECULAR NEUROBIOLOGY
(2020)
Article
Immunology
Min Liu, Zhipeng Xu, Long Wang, Lixia Zhang, Yi Liu, Jiangbei Cao, Qiang Fu, Yanhong Liu, Hao Li, Jingsheng Lou, Wugang Hou, Weidong Mi, Yulong Ma
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Neurosciences
Jin Wang, Yushu Hou, Lixia Zhang, Min Liu, Jianshuai Zhao, Zhen Zhang, Yulong Ma, Wugang Hou
Summary: The study demonstrated that E2 treatment significantly alleviated TBI-induced neuroinflammatory injury by inhibiting microglia and astrocyte activation, reducing neurotoxic astrocyte activation, and inhibiting the TLR4/NF-kappa B pathway. E2 treatment may be a potential therapy strategy for TBI-induced neuroinflammation injury.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Min Liu, Hao Li, Lixia Zhang, Zhipeng Xu, Yuxiang Song, Xiaoyan Wang, Ruitong Chu, Yunming Xiao, Miao Sun, Yulong Ma, Weidong Mi
Summary: The study demonstrated that cottonseed oil has a positive effect on oxidative stress injury induced by ischemic stroke. Treatment with CSO significantly improved neurological deficit, reduced infarction volume, increased antioxidant activity, and activated the Nrf2 signaling pathway in male rats. Additionally, in neuronal cells, CSO treatment increased cell viability, decreased cell apoptosis, and induced Nrf2 nuclear translocation after oxygen and glucose deprivation injury.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Behavioral Sciences
Yulong Ma, Erlong Niu, Fei Xie, Min Liu, Miao Sun, Or Ye Peng, Hang Guo
Summary: The study showed that electroacupuncture could restore the expression levels of estrogen receptors and the neuroprotective effects of estrogen replacement therapy in 10-week ovariectomized rats. However, it was not effective in 20-week ovariectomized rats.
BRAIN AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong Mi
Summary: We found that insulin treatment significantly improved LPS-induced cognitive decline, neuronal injuries, and blood-brain barrier disruption. Insulin treatment inhibited the activation of microglia and astrocytes, and the release of TNF-α and IL-13 in the hippocampus. Furthermore, insulin treatment inhibited LPS-induced ferroptosis in the hippocampus by decreasing iron accumulation levels, regulating ferroptosis-related proteins, and inhibiting oxidative stress injuries and lipid peroxidation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Miao Sun, Min Liu, Qingxiao Li, Xiaoying Zhang, Siyuan Liu, Huikai Yang, Le Yang, Jiahe Tian, Weidong Mi, Yulong Ma
Summary: This study found that cottonseed oil (CSO) can alleviate ferroptosis caused by cerebral ischemic injury in rats. CSO treatment reduces neurological dysfunction, infarct volume, neuronal injuries, and BBB integrity disruption. It also up-regulates anti-ferroptosis proteins and decreases ferroptosis-related proteins, as well as improves mitochondrial destruction induced by ischemic stroke. This provides new evidence for the potential therapeutic mechanism of CSO neuroprotection against ischemic stroke.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Lixia Zhang, Yaqun Ma, Min Liu, Yulong Ma, Hang Guo
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2019)