Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson’s disease via astrocyte-neuron cross talk through complement C3-C3R signaling

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis

(2020) Jennetta W. Hammond et al.   BRAIN BEHAVIOR AND IMMUNITY

The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion

(2020) Nobukazu Miyamoto et al.   GLIA

Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System

(2020) Erik Nutma et al.   Cells

Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease

(2020) Mei-Ling Xia et al.   Journal of Neuroinflammation

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

(2019) Jared T. Hinkle et al.   MOVEMENT DISORDERS

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

(2019) Kristin Hartmann et al.   Acta Neuropathologica Communications

Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson’s disease via promoting mitophagy

(2019) Zhao-Li Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

An update on reactive astrocytes in chronic pain

(2019) Ting Li et al.   Journal of Neuroinflammation

TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease

(2019) Qian-hang Shao et al.   ACTA PHARMACOLOGICA SINICA

Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury

(2019) Dingfei Qian et al.   CELL CYCLE

Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury

(2019) Dylan Laug et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

(2019) Diana Pauly et al.   Cell Reports

The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson's disease

(2019) Heng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic targeting of the complement system

(2019) Daniel Ricklin et al.   NATURE REVIEWS DRUG DISCOVERY

The role of KATP channels in cerebral ischemic stroke and diabetes

(2018) Vivian Szeto et al.   ACTA PHARMACOLOGICA SINICA

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

(2018) Jialei Zhu et al.   CELL DEATH AND DIFFERENTIATION

Endothelial biology and ATP-sensitive potassium channels

(2018) Qadeer Aziz et al.   Channels

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson’s disease

(2018) Ren-Hong Du et al.   Cell Death & Disease

α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes

(2018) Ren-Hong Du et al.   Journal of Neuroinflammation

Complement C3 Inhibition Modulates Neurodegeneration in Chronic Traumatic Brain Injury

(2018) Mary Ellene Boulos et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-specific deletion of Kir6.1/K-ATP channel aggravates cerebral ischemia/reperfusion injury through endoplasmic reticulum stress in mice

(2018) Chong-Jin Zhong et al.   EXPERIMENTAL NEUROLOGY

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

AParkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis

(2017) Dong-Joo Choi et al.   GLIA

Molecular and functional characterization of the endothelial ATP-sensitive potassium channel

(2017) Qadeer Aziz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Developmental activities of the complement pathway in migrating neurons

(2017) Anna Gorelik et al.   Nature Communications

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis

(2016) Iliana Michailidou et al.   GLIA

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

(2012) Marie E. Benoit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement C3a-Induced IL-17 Plays a Critical Role in an IgE-Mediated Late-Phase Asthmatic Response and Airway Hyperresponsiveness via Neutrophilic Inflammation in Mice

(2012) N. Mizutani et al.   JOURNAL OF IMMUNOLOGY

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

C3aR inhibition reduces neurodegeneration in experimental lupus

(2009) A. Jacob et al.   LUPUS

C3a Receptor Modulation of Granulocyte Infiltration after Murine Focal Cerebral Ischemia is Reperfusion Dependent

(2008) Andrew F Ducruet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM