Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study

(2018) Shimaa A.H. Abdel Monaim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin

(2018) Yu Zong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

(2018) Anish Parmar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Short Total Synthesis of [15N5]-Cylindrospermopsins from 15NH4Cl Enables Precise Quantification of Freshwater Cyanobacterial Contamination

(2018) Artur K. Mailyan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing Key Elements of Teixobactin-Lipid II Interactions in Membrane

(2018) Po-Chao Wen et al.   Chemical Science

Total synthesis of teixobactin and its stereoisomers

(2018) L. Liu et al.   Organic Chemistry Frontiers

Structural studies suggest aggregation as one of the modes of action for teixobactin

(2018) Carl Öster et al.   Chemical Science

X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly

(2018) Hyunjun Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chemistry and biology of guanidine natural products

(2017) Roberto G. S. Berlinck et al.   NATURAL PRODUCT REPORTS

Co(OAc)2-Catalyzed Trifluoromethylation and C(3)-Selective Arylation of 2-(Propargylamino)pyridines via a 6-Endo-Dig Cyclization

(2017) Jianjun Li et al.   ORGANIC LETTERS

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

(2017) Anish Parmar et al.   Chemical Science

Synthesis and structure–activity relationship studies of teixobactin analogues

(2017) Chunlei Wu et al.   RSC Advances

Binding Modes of Teixobactin to Lipid II: Molecular Dynamics Study

(2017) Yang Liu et al.   Scientific Reports

Elucidation of the Teixobactin Pharmacophore

(2016) Hyunjun Yang et al.   ACS Chemical Biology

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

(2016) Mareike M. Wiedmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient total syntheses and biological activities of two teixobactin analogues

(2016) Anish Parmar et al.   CHEMICAL COMMUNICATIONS

Total Synthesis of Mannopeptimycins α and β

(2016) Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of Cyclic Guanidines by Directed Diamination of Unactivated Alkenes

(2016) Artur K. Mailyan et al.   ORGANIC LETTERS

Total Synthesis of Teixobactin

(2016) Andrew M. Giltrap et al.   ORGANIC LETTERS

Total synthesis of teixobactin

(2016) Kang Jin et al.   Nature Communications

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

A Highly Stereoselective and Scalable Synthesis of l-allo-Enduracididine

(2015) William Craig et al.   ORGANIC LETTERS

Synthesis and Biological Evaluation of a Teixobactin Analogue

(2015) Yahya E. Jad et al.   ORGANIC LETTERS

Vicinal Diamination of Alkenes under Rh-Catalysis

(2014) David E. Olson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoactivatable Lipid Probes for Studying Biomembranes by Photoaffinity Labeling

(2013) Yi Xia et al.   CHEMICAL REVIEWS

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Condensation reactions of guanidines with bis-electrophiles: formation of highly nitrogenous heterocycles

(2013) David M. Arnold et al.   TETRAHEDRON

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Metal-catalysed 1,2-diamination reactions

(2009) Francesca Cardona et al.   Nature Chemistry