Review
Biochemistry & Molecular Biology
Na Song, Ming Yang, Hao Zhang, Shi-kun Yang
Summary: Kidney disease is a serious health concern, and understanding the pathogenesis is crucial for precise therapies. Disruption of calcium homeostasis plays a fundamental role in kidney disease development and is a promising therapeutic strategy. The endoplasmic reticulum and mitochondria are key organelles, with pharmacologic modulation of cellular calcium homeostasis as a novel treatment approach.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Andras Sandor, Marketa Samalova, Federica Brandizzi, Verena Kriechbaumer, Ian Moore, Mark D. Fricker, Lee J. Sweetlove
Summary: In this study, we characterized membranous compartments derived from the endoplasmic reticulum (ER) in tobacco. We found that the morphology of the final compartment is affected by the introduction of polyproteins into the ER membrane, and a cytosol-facing oligomerization domain is essential for compartment formation. We also discovered the existence of a diffusional barrier between the compartment, ER, and cytosol, and showed that the presence of the compartment does not disrupt the rest of the ER network.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Cell Biology
Eunhee Kim, Dong Min Lee, Min Ji Seo, Hong Jae Lee, Kyeong Sook Choi
Summary: Paraptosis is a type of programmed cell death characterized by dilation of the endoplasmic reticulum and/or mitochondria. Ca2+ transport has been shown to play an important role in paraptosis induced by various agents, and perturbations of cellular proteostasis and ion homeostasis are believed to contribute critically to the process. The communication between the ER and mitochondria mediated by Ca2+ appears to be crucial in inducing paraptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Michiko Shirane, Hiroyuki Kamiguchi
Summary: Axon growth and guidance in the developing nervous system rely on intracellular membrane dynamics that involve endosome maturation and transport, as well as its regulated tethering to the endoplasmic reticulum (ER). Recent studies have identified several key molecules, such as protrudin, which plays a dynamic role at membrane contact sites between the ER and endosomes/lysosomes, and myosin Va, which acts as a sensor for ER-derived Ca2+ that triggers peri-ER membrane export. These molecules form different types of multiprotein complexes at the interface of organelles and, in response to their surrounding microenvironments, such as Ca2+ concentrations and lipid contents, regulate the directional movement of endosomal vesicles in extending axons. Here, we review the molecular mechanisms underlying membrane dynamics and inter-organelle interactions during neuronal morphogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Materials Science, Biomaterials
Si-Yi Chen, Xiao-Xue Xu, Xin Li, Ning-Bo Yi, Shi-Zhuo Li, Xing-Cheng Xiang, Dong-Bing Cheng, Taolei Sun
Summary: This article summarizes the uptake pathway of intracellular delivery vehicles for macromolecule drugs, emphasizing the importance of optimizing drug delivery systems, maintaining biological activity, improving transport efficiency, and discovering new therapies.
BIOMATERIALS SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Chunai Gong, Xiaoyan Yu, Wei Zhang, Lu Han, Rong Wang, Yujie Wang, Shen Gao, Yongfang Yuan
Summary: A pH-responsive co-delivery platform was developed to target Met-facilitated PD-L1 degradation and siFGL1 delivery for FGL1 gene silencing, demonstrating high synergistic therapeutic efficacy against breast cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Cell Biology
Kouminin Kanwore, Piniel Alphayo Kambey, Xiao-Xiao Guo, Ayanlaja Abdulrahman Abiola, Ying Xia, Dianshuai Gao
Summary: The external and internal factors of the cell play a critical role in glioma initiation, with multiple factors and molecules implicated in brain cancer progression. Glioma stem cells have been identified as the origin, and oncogene overexpression is involved in tumorigenesis, maintenance, and progression. Additionally, defects in cell organelles contribute to cancer cell resistance to drugs, apoptosis, and immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Adrian B. Mehrtash, Mark Hochstrasser
Summary: The study reveals that the conserved C-terminal element of Doa10 promotes E3-mediated Ubc6 activity, and substrates undergoing an alternative ubiquitylation mechanism are still degraded in its mutant cells. Structure predictions and intragenic suppression confirm the direct role of CTE in substrate ubiquitylation, while truncation analysis defines a minimal E2-binding region of Doa10.
Review
Biochemistry & Molecular Biology
Yeong-Min Yoo, Seong Soo Joo
Summary: As people age, their risks of developing degenerative diseases such as cancer, diabetes, Parkinson's Disease (PD), Alzheimer's Disease (AD), rheumatoid arthritis, and osteoporosis increase. Neurodegenerative diseases are recognized as the leading cause of affliction in the elderly worldwide. Research suggests that endoplasmic reticulum (ER) stress is associated with some neurological diseases like PD and AD. Melatonin, a hormone synthesized in the pineal gland, has various biological functions including circadian rhythm control, immune enhancement, and antioxidant, anti-aging, and anti-tumor effects. This paper aims to summarize the effects of melatonin on neurons and neurodegenerative diseases related to ER stress, highlighting its role in protecting neurons and treating neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Selma Yilmaz Dejgaard, John F. Presley
Summary: This review focuses on the role of membrane trafficking in the life cycle of lipid droplets, including their biogenesis, attachment, catabolism, and eventual demise, with particular attention to the involvement of small GTPases such as Rab18 in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Akande Rouchidane Eyitayo, Mathilde Gonin, Hubert Arokium, Stephen Manon
Summary: BCL-2 family members are key regulators of apoptotic cell death in mammals. Studying their ectopic expression in yeast provides valuable insights into their function and regulation mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ben Zucker, Michael M. Kozlov
Summary: Recent advances in super-resolution microscopy revealed previously unknown nanoscopic organization of endoplasmic reticulum (ER), including various nanostructures, and proposed a common concept based on membrane intrinsic curvature and ultra-low membrane tensions as key factors shaping these structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Junjun Peng, Xueyan Dai, Huiqin Fan, Chenghong Xing, Yu Zhuang, Xiaona Gao, Huabin Cao, Guoliang Hu, Fan Yang
Summary: Copper (Cu) at high levels can cause harm to the host physiology, specifically resulting in nephrotoxicity, although the exact mechanism remains unclear. This study explored the relationship between mitochondria-associated ER membranes (MAM) and Cu-induced kidney mitochondrial dysfunction and ER stress. The findings revealed that excessive Cu disrupted MAM integrity, leading to MAM dysfunction, mitochondrial dysfunction, and ER stress, contributing to Cu-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biophysics
Huizi Man, Hui Bian, Xinfu Zhang, Chao Wang, Zhenlong Huang, Yu Yan, Zhiwei Ye, Yi Xiao
Summary: The endoplasmic reticulum (ER) undergoes morphological changes under stress conditions, and precise observations of ER can provide insights into disease diagnoses and biological research. Super-resolution imaging is highly anticipated for revealing the microstructures of ER.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Endocrinology & Metabolism
Gonzalo Fernandez-Fuente, Michael J. Rigby, Luigi Puglielli
Summary: By regulating intracellular signaling molecules, especially the citrate/acetyl-CoA pathway, homeostatic responses in cells can be activated. The citrate/acetyl-CoA pathway plays important roles in various biological functions within cells and is associated with N epsilon-lysine acetylation. Specifically, in the acetylation machinery of the endoplasmic reticulum (ER), ER acetylation regulates metabolic communication and homeostasis between different cellular organelles, affecting cellular adaptive responses and specific disease states. Therefore, citrate and acetyl-CoA should be recognized as both metabolic substrates and important signaling molecules for cellular adaptation.
MOLECULAR METABOLISM
(2023)
Article
Nanoscience & Nanotechnology
Wei Wei, Jing Sun, Xi-Ying Guo, Xin Chen, Ru Wang, Chong Qiu, Hai-Tao Zhang, Wen-Hao Pang, Jian-Cheng Wang, Qiang Zhang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Medicine, Research & Experimental
Hai-Tao Zhang, Minzhi Yu, Yu-Jie Niu, Wei-Zhong Liu, Wen-Hao Pang, Jinsong Ding, Jian-Cheng Wang
MOLECULAR PHARMACEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Piao-Piao Li, Yi Yan, Hai-Tao Zhang, Shi-he Cui, Cheng-Han Wang, Wei Wei, Hong-Gang Qian, Jian-Cheng Wang, Qiang Zhang
JOURNAL OF CONTROLLED RELEASE
(2020)
Correction
Medicine, Research & Experimental
Wenwen Du, Yuchen Fan, Bing He, Nan Zheng, Lan Yuan, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Qiaoli Shi, Qixin Wang, Jiayun Chen, Fei Xia, Chong Qiu, Min Li, Minghong Zhao, Qian Zhang, Piao Luo, Tianming Lu, Ying Zhang, Liting Xu, Xueling He, Tianyu Zhong, Na Lin, Qiuyan Guo
Summary: This study suggests that Glycyrrhizic acid can alleviate TGT-induced acute liver injury partly by regulating the activities of CYP and the metabolism of PC and PE.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biophysics
Fangjie Li, Yuning Luo, Xiaoyi Feng, Yuqiong Guo, Yue Zhou, Dongxiu He, Zhizhong Xie, Haitao Zhang, Yang Liu
Summary: This article provides a systematic overview of the development, preparation, and applications of 2D colloidal crystals of soft microgel spheres. Various preparation methods and representative biomedical applications are introduced, showcasing the high performance of these crystals in optical sensing, drug delivery, antibacterial coatings, cell culture, and colloidal templates.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Yuqing Meng, Jiayun Chen, Yanqing Liu, Yongping Zhu, Yin-Kwan Wong, Haining Lyu, Qiaoli Shi, Fei Xia, Liwei Gu, Xinwei Zhang, Peng Gao, Huan Tang, Qiuyan Guo, Chong Qiu, Chengchao Xu, Xiao He, Junzhe Zhang, Jigang Wang
Summary: The composition of serum is highly complex, making the discovery of new pharmacodynamic biomarkers challenging. This study developed a nanoparticle-based proteomic analysis strategy to enhance the range of serum proteomic analysis. The strategy successfully identified more proteins and enriched biological processes, providing potential pharmacodynamic biomarkers for disease prediction, diagnosis, and treatment.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Haitao Zhang, Yangchun Zhou, Chenghui Xu, Xuping Qin, Zifen Guo, Hua Wei, Cui-Yun Yu
Summary: This review summarizes the applications of nanoparticles (NPs) based on different ionic polysaccharides for controlled release. It focuses on optimizing polysaccharide structures to achieve maximum synergistic effects. The review introduces strategies for overcoming extracellular and intracellular barriers, summarizes four preparation strategies, and discusses challenges and future trends. The guidelines provided will promote the use of polysaccharides-based NPs in cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Chong Qiu, Yanyan Wu, Qiaoli Shi, Qiuyan Guo, Junzhe Zhang, Yuqing Meng, Chen Wang, Fei Xia, Jigang Wang, Chengchao Xu
Summary: Cancer is a complex malignant consequence of genetic mutations that control cellular processes, making tumor treatment extremely challenging. Various cargo molecules, including nucleic acids drugs, therapeutic drugs and imaging agents, have shown potential in clinical applications. However, the heterogeneity of tumors and drug resistance limit the effectiveness of single therapeutic drugs, leading to the adoption of nanotechnology-based combined therapy for enhanced anticancer effects. This review discusses the current advanced development in co-delivering small-molecular drugs and nucleic acids for anticancer therapy with nanomedicine-based combination, highlighting the superiority and addressing the barriers to overcome clinical challenges. Future perspectives in rational direction for combined tumor therapy of drugs and nucleic acids are also presented.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qixin Wang, Yuwen Huang, Yu Li, Luyun Zhang, Huan Tang, Junzhe Zhang, Guangqing Cheng, Minghong Zhao, Tianming Lu, Qian Zhang, Piao Luo, Yinhua Zhu, Fei Xia, Ying Zhang, Dandan Liu, Chen Wang, Haiyan Li, Chong Qiu, Jigang Wang, Qiuyan Guo
Summary: This study found that glycyrrhizic acid (GA) can mitigate acute liver injury caused by Tripterygium glycoside tablet (TGT) by mediating PKM2, reducing oxidative stress and inflammation, and reducing hepatocyte apoptosis.
Article
Engineering, Biomedical
Chong Qiu, Yanyan Wu, Qiuyan Guo, Qiaoli Shi, Junzhe Zhang, Yuqing Meng, Fei Xia, Jigang Wang
Summary: Calcium phosphate nanoparticles have favorable properties for drug delivery and have been extensively developed in terms of design and preparation. This review discusses the recent developments in the use of calcium phosphate nanocarriers as drug delivery systems and therapeutic agents.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Yang Qin, Haitao Zhang, Yunxian Li, Ting Xie, Shuang Yan, Jiaqi Wang, Jun Qu, Feijun Ouyang, Shaoyang Lv, Zifen Guo, Hua Wei, Cui-Yun Yu
Summary: Immunotherapy is a promising treatment strategy for cancer, but its efficacy is compromised by low immune activity of tumor cells and an immunosuppressive microenvironment. Immunogenic cell death (ICD) has gained attention for its potential to stimulate a potent immune response, but its effectiveness is still limited by the complex tumor microenvironment and drawbacks of inducing agents.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Qiuyan Guo, Jiangpeng Wu, Qixin Wang, Yuwen Huang, Lin Chen, Jie Gong, Maobo Du, Guangqing Cheng, Tianming Lu, Minghong Zhao, Yuan Zhao, Chong Qiu, Fei Xia, Junzhe Zhang, Jiayun Chen, Feng Qiu, Jigang Wang
Summary: This study aims to investigate the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing (scRNA-seq) technology. The findings reveal that TGT causes a significant inflammatory response, apoptosis, fatty acid metabolism dysfunction, cell activation, and immune dysfunction in different types of liver cells.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Multidisciplinary Sciences
Chong Qiu, Fei Xia, Junzhe Zhang, Qiaoli Shi, Yuqing Meng, Chen Wang, Huanhuan Pang, Liwei Gu, Chengchao Xu, Qiuyan Guo, Jigang Wang
Summary: Nanocarriers have therapeutic potential for drug delivery, but their efficiency is limited by endosomal/lysosomal degradation. This review summarizes advanced strategies for overcoming this barrier, including promoting endosomal/lysosomal escape, using non-endocytic delivery methods, and taking a detour pathway. Several promising strategies are proposed for smarter and more efficient nanodrug delivery systems.
Article
Chemistry, Organic
Fei Xia, Yu-Qian Lu, Peng Sun, Qiu-Yan Guo, Qiao-Li Shi, Jun-Zhe Zhang, Chong Qiu
Summary: A formal [4 + 2] annulation of diamines and prop-2-ynyl sulfonium salts has been developed, providing an efficient access to tetrahydroquinoxalines in excellent yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
