Optimal control nodes in disease-perturbed networks as targets for combination therapy
出版年份 2019 全文链接
标题
Optimal control nodes in disease-perturbed networks as targets for combination therapy
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-05-16
DOI
10.1038/s41467-019-10215-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Harnessing synthetic lethality to predict the response to cancer treatment
- (2018) Joo Sang Lee et al. Nature Communications
- O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress
- (2017) Weiqi Xu et al. JOURNAL OF HEPATOLOGY
- Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer
- (2017) Masahiro Kai et al. MOLECULAR CARCINOGENESIS
- Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
- (2017) Kyuho Han et al. NATURE BIOTECHNOLOGY
- Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- (2017) Robin M Meyers et al. NATURE GENETICS
- Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions
- (2017) John Paul Shen et al. NATURE METHODS
- Predictive approaches for drug combination discovery in cancer
- (2016) Seyed Ali Madani Tonekaboni et al. BRIEFINGS IN BIOINFORMATICS
- Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase
- (2016) Y. Bai et al. CANCER RESEARCH
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Functional characterization of somatic mutations in cancer using network-based inference of protein activity
- (2016) Mariano J Alvarez et al. NATURE GENETICS
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- COSMIC: somatic cancer genetics at high-resolution
- (2016) Simon A. Forbes et al. NUCLEIC ACIDS RESEARCH
- KEGG: new perspectives on genomes, pathways, diseases and drugs
- (2016) Minoru Kanehisa et al. NUCLEIC ACIDS RESEARCH
- Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets
- (2016) Arunachalam Vinayagam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Controllability analysis of transcriptional regulatory networks reveals circular control patterns among transcription factors
- (2015) Tobias Österlund et al. Integrative Biology
- SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets
- (2015) Jing Guo et al. NUCLEIC ACIDS RESEARCH
- Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
- (2015) Hong Yang et al. NUCLEIC ACIDS RESEARCH
- The Reactome pathway Knowledgebase
- (2015) Antonio Fabregat et al. NUCLEIC ACIDS RESEARCH
- Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment
- (2015) Adam A. Friedman et al. PLoS One
- Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer
- (2015) Yi Sun et al. Nature Communications
- DrugComboRanker: drug combination discovery based on target network analysis
- (2014) L. Huang et al. BIOINFORMATICS
- Detection of driver metabolites in the human liver metabolic network using structural controllability analysis
- (2014) Xueming Liu et al. BMC Systems Biology
- RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer
- (2014) Naoki Kaneto et al. CANCER SCIENCE
- Charting a path toward combination therapy for Alzheimer’s disease
- (2014) Diane Stephenson et al. Expert Review of Neurotherapeutics
- OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders
- (2014) Joanna S. Amberger et al. NUCLEIC ACIDS RESEARCH
- Target control of complex networks
- (2014) Jianxi Gao et al. Nature Communications
- Systematic identification of proteins that elicit drug side effects
- (2013) M. Kuhn et al. Molecular Systems Biology
- A large-scale evaluation of computational protein function prediction
- (2013) Predrag Radivojac et al. NATURE METHODS
- A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer
- (2013) S Postel-Vinay et al. ONCOGENE
- Structure and dynamics of molecular networks: A novel paradigm of drug discovery
- (2013) Peter Csermely et al. PHARMACOLOGY & THERAPEUTICS
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- A single source k-shortest paths algorithm to infer regulatory pathways in a gene network
- (2012) Yu-Keng Shih et al. BIOINFORMATICS
- Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
- (2012) Augusto Villanueva et al. GASTROENTEROLOGY
- Combinatorial drug therapy for cancer in the post-genomic era
- (2012) Bissan Al-Lazikani et al. NATURE BIOTECHNOLOGY
- Controlling edge dynamics in complex networks
- (2012) Tamás Nepusz et al. Nature Physics
- The growing complexity of HIF-1α’s role in tumorigenesis: DNA repair and beyond
- (2012) N Rohwer et al. ONCOGENE
- Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis
- (2012) Y.-d. Yao et al. Science Translational Medicine
- Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
- (2012) Levi A. Garraway et al. Cancer Discovery
- Prioritizing candidate disease genes by network-based boosting of genome-wide association data
- (2011) I. Lee et al. GENOME RESEARCH
- Controllability of complex networks
- (2011) Yang-Yu Liu et al. NATURE
- A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
- (2010) Celine Lefebvre et al. Molecular Systems Biology
- Epigenetic modifications as therapeutic targets
- (2010) Theresa K Kelly et al. NATURE BIOTECHNOLOGY
- Pathway Commons, a web resource for biological pathway data
- (2010) E. G. Cerami et al. NUCLEIC ACIDS RESEARCH
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Identification of Potential Driver Genes in Human Liver Carcinoma by Genomewide Screening
- (2009) H. G. Woo et al. CANCER RESEARCH
- Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1
- (2009) R. Sullivan et al. MOLECULAR CANCER THERAPEUTICS
- Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer
- (2009) M. Dokmanovic et al. MOLECULAR CANCER THERAPEUTICS
- Mechanisms of drug combinations: interaction and network perspectives
- (2009) Jia Jia et al. NATURE REVIEWS DRUG DISCOVERY
- PID: the Pathway Interaction Database
- (2008) Carl F. Schaefer et al. NUCLEIC ACIDS RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started