Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

(2019) Michael Dietrich et al.   Jove-Journal of Visualized Experiments

Retinal Neuroprotection: Overcoming the Translational Roadblocks

(2018) Thomas J. Wubben et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Inhibiting autophagy reduces retinal degeneration caused by protein misfolding

(2018) Jingyu Yao et al.   Autophagy

Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration

(2018) Ekaterina S. Lobanova et al.   Nature Communications

Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3)

(2016) Amy Aldrich et al.   ANNALS OF NEUROLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

(2016) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

Autophagic flux determination in vivo and ex vivo

(2015) Lorena Esteban-Martínez et al.   METHODS

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors

(2014) Olga S. Sizova et al.   CELLULAR SIGNALLING

Retinal cell death and current strategies in retinal neuroprotection

(2014) Nicholas D. Chinskey et al.   CURRENT OPINION IN OPHTHALMOLOGY

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration

(2014) Wei-Chieh Chiang et al.   MOLECULAR NEUROBIOLOGY

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hsp90 inhibition protects against inherited retinal degeneration

(2013) Mònica Aguilà et al.   HUMAN MOLECULAR GENETICS

P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis

(2013) S. Sakami et al.   HUMAN MOLECULAR GENETICS

Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration

(2013) E. S. Lobanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photoreceptor cell death and rescue in retinal detachment and degenerations

(2013) Yusuke Murakami et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

4-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress, Trypsin Activation, and Acinar Cell Apoptosis While Increasing Secretion in Rat Pancreatic Acini

(2012) Antje Malo et al.   PANCREAS

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

(2011) Jeffrey Haspel et al.   Autophagy

Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations

(2011) Sanae Sakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: Safety, pharmacokinetics and ammonia control

(2010) Brendan Lee et al.   MOLECULAR GENETICS AND METABOLISM

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa

(2008) Hugo F. Mendes et al.   HUMAN MOLECULAR GENETICS