Concise Review: Beta-Cell Dedifferentiation in Type 2 Diabetes

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

(2019) Nadav Sharon et al.   CELL

The obesity transition: stages of the global epidemic

(2019) Lindsay M Jaacks et al.   Lancet Diabetes & Endocrinology

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

(2018) Tess Tsai-Hsiu Lu et al.   Cell Metabolism

Modeling human pancreatic beta cell dedifferentiation

(2018) Marc Diedisheim et al.   Molecular Metabolism

Genetics of Monogenic Diabetes: Present Clinical Challenges

(2018) Shivani Misra et al.   Current Diabetes Reports

Increased vimentin in human α- and β-cells in type 2 diabetes

(2017) Maaike M Roefs et al.   JOURNAL OF ENDOCRINOLOGY

Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

(2017) Matthias Thurner et al.   Stem Cell Reports

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes

(2016) Yurong Xin et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery

(2016) Hui Zeng et al.   Cell Stem Cell

Single-Cell Transcriptomics of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   DIABETES

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

(2016) Soren K. Thomsen et al.   DIABETES

β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation

(2016) Alexandra E. Butler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

Natural history of β-cell adaptation and failure in type 2 diabetes

(2015) Emilyn U. Alejandro et al.   MOLECULAR ASPECTS OF MEDICINE

TGFβ Pathway Inhibition Redifferentiates Human Pancreatic Islet β Cells Expanded In Vitro

(2015) Ginat Toren-Haritan et al.   PLoS One

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Redifferentiation of Adult Human β Cells Expanded In Vitro by Inhibition of the WNT Pathway

(2014) Ayelet Lenz et al.   PLoS One

Pancreatic β-Cell Proliferation in Obesity

(2014) Amelia K. Linnemann et al.   Advances in Nutrition

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Expression of Mesenchymal and  -Cell Phenotypic Markers in Islet  -Cells in Recently Diagnosed Diabetes

(2013) M. G. White et al.   DIABETES CARE

Evidence of Reduced β-Cell Function in Asian Indians With Mild Dysglycemia

(2013) Lisa R. Staimez et al.   DIABETES CARE

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway

(2012) Yael Bar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis

(2009) Henry Buchwald et al.   AMERICAN JOURNAL OF MEDICINE

Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells

(2009) Holger A. Russ et al.   PLoS One

HES-1 Is Involved in Adaptation of Adult Human  -Cells to Proliferation In Vitro

(2008) Y. Bar et al.   DIABETES

In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing

(2008) H. A. Russ et al.   DIABETES