Review
Biochemistry & Molecular Biology
Flaminia Pugnaloni, Irma Capolupo, Neil Patel, Paola Giliberti, Andrea Dotta, Pietro Bagolan, Florian Kipfmueller
Summary: This review highlights the importance of miRNAs in CDH-related PH and summarizes the findings from animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers potential for developing innovative diagnostic tools and treatment approaches, and enhances researchers' understanding of CDH pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel, Rory E. Morty, Robbert J. Rottier
Summary: Studies on the activation of TGF beta and BMP signaling pathways in CDH are limited and inconsistent. However, research on a nitrofen-CDH rat model suggests increased activation of TGF beta pathway and decreased activation of BMP pathway in pulmonary vasculature, which may contribute to the development of pulmonary hypertension in CDH.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Shiho Yoshida, Alexander M. Kreger, George K. Gittes
Summary: We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for CDH-induced pulmonary hypertension. Intra-amniotic sildenafil treatment attenuated peripheral vascular muscularization, enhanced pulmonary blood flow, and improved lung architecture in CDH fetuses. Early intervention with intra-amniotic sildenafil treatment may be preferable to accelerate lung development and improve prognosis in CDH cases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Florian Kipfmueller, Suemeyra Akkas, Flaminia Pugnaloni, Bartolomeo Bo, Lotte Lemloh, Lukas Schroeder, Ulrich Gembruch, Annegret Geipel, Christoph Berg, Andreas Heydweiller, Andreas Mueller
Summary: The study suggests that PAAT:ET has potential as a prognostic indicator in neonates with congenital diaphragmatic hernia. This parameter can be used for early assessment of ECMO requirement and mortality risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Alecsander F. Bressan, Victoria Oliveira Maia, Beatriz de Souza Rodrigues, Giuliana Bertozi, Sabrina S. Batah, Alexandre T. Fabro, Gloria Pelizzo, Ugo Maria Pierucci, Rita C. Tostes, Lourenco Sbragia, Fernando S. Carneiro
Summary: Congenital diaphragmatic hernia (CDH) can cause abnormalities in the pulmonary arteries of both the contralateral and ipsilateral sides of the diaphragm. Nitric oxide (NO) is commonly used to treat CDH but may not always be effective. This study investigated the different responses of the left and right pulmonary arteries to a NO donor in a rabbit model of left CDH. The results showed that newborns with CDH had increased vasorelaxant responses to the NO donor compared to the control group, possibly due to increased cGMP mobilization.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Felix Rafael De Bie, Christopher Gates Halline, Travis Kotzur, Kevin Hayes, Christopher Copeland Rouse, Jonathan Chang, Abby Christine Larson, Sameer Ahmad Khan, Ashley Spina, Samantha Tilden, Francesca Maria Russo, Holly Lee Hedrick, Jan Deprest, Emily Anne Partridge
Summary: In a nitrofen rat model, prenatal administration of treprostinil significantly reduces pulmonary arteriole muscularization. These results suggest that prophylactic treatment may be a potential approach for managing CDH-related PH.
Article
Pediatrics
Vikas S. Gupta, Neil Patel, Florian Kipfmueller, Pamela A. Lally, Kevin P. Lally, Matthew T. Harting
Summary: Elevated proBNP levels are associated with high-risk defects, ventricular dysfunction, and mortality in CDH patients, indicating proBNP's potential as a biomarker for cardiac dysfunction in CDH.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Judith Leyens, Lukas Schroeder, Annegret Geipel, Christoph Berg, Bartolomeo Bo, Lotte Lemloh, Neil Patel, Andreas Mueller, Florian Kipfmueller
Summary: This study aims to describe the early course of pulmonary hypertension (PH) in infants with congenital diaphragmatic hernia (CDH) and its relation to prognostic markers and outcome measures. The severity of PH varied significantly in the first 48 hours of life. Patients with mild/no PH had a better prognosis, while patients with severe PH had a higher risk of mortality and ECMO. Assessing PH within 2-6 hours is crucial in the care for CDH neonates.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Arthur Gavotto, Pascal Amedro, Gilles Cambonie
Summary: We report a case of a neonate with a severe pulmonary hypertension associated with an abnormal origin of the right pulmonary artery from the right brachiocephalic artery, in a context of left congenital diaphragmatic hernia (CDH). To the best of our knowledge, this combination of malformations has not been reported before.
Article
Physiology
Krithika Lingappan, Oluyinka O. Olutoye, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. Keswani
Summary: This is the first application of spatial transcriptomics in patients with CDH, revealing the contribution of different lung cellular subpopulations in CDH pathophysiology and highlighting sex-specific differences.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Pediatrics
Dalya Munves Ferguson, Vikas S. Gupta, Pamela A. Lally, Matias Luco, KuoJen Tsao, Kevin P. Lally, Neil Patel, Matthew T. Harting
Summary: The study found that early CDH-PH is associated with increased risk for inpatient mortality or oxygen support at 30 days. Infants with moderate CDH-PH and severe CDH-PH had a higher incidence of the primary outcome, while severe CDH-PH was also associated with a higher likelihood of requiring ECLS support.
Article
Pediatrics
Florian Kipfmueller, Judith Leyens, Flaminia Pugnaloni, Bartolomeo Bo, Tamara Grass, Lotte Lemloh, Lukas Schroeder, Patrizia Nitsch-Felsecker, Christoph Berg, Andreas Heydweiller, Brigitte Strizek, Andreas Mueller
Summary: This study explored the feasibility and outcomes of a spontaneous breathing approach (SBA) versus immediate intubation in neonates with prenatally diagnosed very mild congenital diaphragmatic hernia (CDH). The results showed that SBA was successful in most cases, and it was associated with shorter hospital stay, less mechanical ventilation and oxygen supplementation, as well as improved early feeding tolerance compared to standard treatment.
PEDIATRIC PULMONOLOGY
(2023)
Review
Pediatrics
Srirupa Hari Gopal, Neil Patel, Caraciolo J. Fernandes
Summary: Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly with complex pathophysiology. The use of PGE1 infusion as a management strategy for CDH-related pulmonary hypertension has shown promising results in optimizing cardiac function and blood flow.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Megan A. Coughlin, Vikas S. Gupta, Ashley H. Ebanks, Matthew T. Harting, Kevin P. Lally
Summary: The study on CDH + BPS patients found that pulmonary sequestration is associated with larger defect sizes, a greater need for ECLS, and higher mortality rates.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Surgery
Oluyinka O. Olutoye II, Steven C. Mehl, Anoosha Moturu, Rowland W. Pettit, Ryan D. Coleman, Adam M. Vogel, Timothy C. Lee, Sundeep G. Keswani, Alice King
Summary: In patients with congenital diaphragmatic hernia, there is no significant difference in perinatal management between those with LH <20% and >=20%, suggesting that the historical cutoff of >=20% LH may not be sufficient to guide clinical decision-making.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Duy T. Dao, Carmen M. Burgos, Matthew T. Harting, Kevin P. Lally, Pamela A. Lally, Hong-An T. Nguyen, Jay M. Wilson, Terry L. Buchmiller
Summary: The study indicates that early repair of CDH after ECMO cannulation is associated with improved survival and lower incidence of non-repair compared to delayed surgical correction.
Article
Pediatrics
Sahar Al Baroudi, Joseph M. Collaco, Pamela A. Lally, Matthew T. Harting, Eric B. Jelin
PEDIATRIC PULMONOLOGY
(2020)
Article
Surgery
Kerri Ohman, Huirong Zhu, Ilan Maizlin, Regan F. Williams, Yigit S. Guner, Robert T. Russell, Matthew T. Harting, Adam M. Vogel, Joanne P. Starr, Dana Johnson, Roy Ramirez, Lisa Manning
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Pediatrics
Megan A. Coughlin, Vikas S. Gupta, Ashley H. Ebanks, Matthew T. Harting, Kevin P. Lally
Summary: The study on CDH + BPS patients found that pulmonary sequestration is associated with larger defect sizes, a greater need for ECLS, and higher mortality rates.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Obstetrics & Gynecology
Vikas S. Gupta, Dalya M. Ferguson, Pamela A. Lally, Elisa Garcia, Kyle G. Mitchell, Kuojen Tsao, Kevin P. Lally, Matthew T. Harting
Summary: In CDH patients, LBW is a risk factor for mortality and pulmonary morbidity. Prolonged oxygen requirement and increased length of stay are important considerations when managing this population.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
Dalya Munves Ferguson, Vikas S. Gupta, Pamela A. Lally, Matias Luco, KuoJen Tsao, Kevin P. Lally, Neil Patel, Matthew T. Harting
Summary: The study found that early CDH-PH is associated with increased risk for inpatient mortality or oxygen support at 30 days. Infants with moderate CDH-PH and severe CDH-PH had a higher incidence of the primary outcome, while severe CDH-PH was also associated with a higher likelihood of requiring ECLS support.
Article
Surgery
Vikas S. Gupta, Matthew T. Harting, Pamela A. Lally, Charles C. Miller, Ronald B. Hirschl, Carl F. Davis, MelvinIII S. Dassinger, Terry L. Buchmiller, Krisa P. Van Meurs, Bradley A. Yoder, Michael J. Stewart, Kevin P. Lally
Summary: This study examines the risk-adjusted survival rates of CDH patients over the past 25 years in long-term participants of the CDH Study Group. The results show that the risk-adjusted and observed-to-expected mortality rates for CDH have improved over time.
Article
Critical Care Medicine
Vikas S. Gupta, Hayes Don, Stephanie C. Hsu, Joseph E. Tonna, Peter T. Rycus, Brian C. Bridges, Fatima Diaban, Karen J. Bosma, Jayesh M. Bhatt, Nicole M. Sakla, Jason J. Han, Christian A. Bermudez, Frank Manetta, Elisa Garcia, Matthew T. Harting
Summary: Electronic cigarette or vaping product use-associated lung injury can lead to respiratory failure and death. The role of extracorporeal life support in its management remains unclear. This study analyzed the clinical characteristics and outcomes of patients with electronic cigarette or vaping product use-associated lung injury who received extracorporeal life support. It found that venovenous extracorporeal life support can be an effective treatment option for profound, refractory respiratory failure secondary to electronic cigarette or vaping product use-associated lung injury.
CRITICAL CARE MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Siqin Zhaorigetu, Vikas S. Gupta, Di Jin, Matthew T. Harting
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Education, Scientific Disciplines
Vikas S. Gupta, Jennie Meier, Johanna H. Nunez, Kareem R. Abdelfattah, Courtney Balentine, Herb J. Zeh, Deborah Carlson, Benjamin Levi
Summary: The implementation of a department-wide research curriculum and infrastructure has effectively promoted academic collaboration and productivity among participants at all levels, including trainees and junior investigators. By providing access to resources like data analysis tools, manuscript and grant writing templates, and a variety of lectures, the initiative has successfully reached over 40 UTSW Surgery trainees and staff, serving as a blueprint for other institutions.
JOURNAL OF SURGICAL EDUCATION
(2022)
Article
Surgery
Vikas S. Gupta, Ioannis N. Liras, Myron Allukian, Bryan A. Cotton, Charles S. Cox, Matthew T. Harting
Summary: The study investigated the relationship between rTEG values and mortality in trauma patients younger than 5 years old, finding that while rTEG identified coagulopathy, it was not an independent predictor of death. Admission base deficit, arrival temperature, and head injury severity were identified as independent predictors of mortality in these young trauma patients.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Pediatrics
Vikas S. Gupta, Cory Wilson, Elizabeth C. Popp, Siqin Zhaorigetu, Scott Collum, Di Jin, Amir M. Khan, Harry Karmouty-Quintana, Kevin P. Lally, Matthew T. Harting
Summary: This study aimed to investigate the association between congenital diaphragmatic hernia (CDH) severity and differences in oxygenation, airway resistance, and pulmonary mechanics. Using a murine model and patient data, it was found that CDH infants had lower SpO2, airway resistance, and tidal volumes compared to control infants.
PEDIATRIC PULMONOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Faheem Sheriff, Haolin Xu, Alberto Maud, Vikas Gupta, Anantha Vellipuram, Gregg C. Fonarow, Roland A. Matsouaka, Ying Xian, Mathew Reeves, Eric E. Smith, Jeffrey Saver, Gustavo Rodriguez, Salvador Cruz-Flores, Lee H. Schwamm
Summary: According to this study, there are differences in EVT use and outcomes among racial and ethnic groups in patients with acute ischemic stroke. Although the disparities in EVT use between Black and Asian patients and non-Hispanic White patients have narrowed over time, they still exist. However, the study also found that racial and ethnic underrepresented groups have slightly more favorable outcomes in terms of discharge-related results.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Emergency Medicine
Vikas S. Gupta, Kristen Burke, Brandon R. Bruns, Ryan P. Dumas
Summary: The purpose of this study is to describe an institutional trauma nurse screening procedure and evaluate its effectiveness in triaging injured patients. The results suggest that nursing screening protocols can be safe and effective tools for triage of trauma patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Meeting Abstract
Pediatrics
Vikas S. Gupta, Neil Patel, Pamela A. Lally, Kevin P. Lally, Matthew T. Harting