Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease

(2019) Denise Mafra et al.   Nutrients

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling

(2019) Sanjay K. Nigam et al.   Nature Reviews Nephrology

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance

(2019) Britt Opdebeeck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease

(2018) Sanjay K. Nigam   Annual Review of Pharmacology and Toxicology

Probiotic Lactobacillus paracasei HII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 (Oat3) function

(2018) Keerati Wanchai et al.   CLINICAL SCIENCE

Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters

(2017) Pedro Caetano-Pinto et al.   MOLECULAR PHARMACEUTICS

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

(2017) Wei Wu et al.   Scientific Reports

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

(2016) Tom T. G. Nieskens et al.   AAPS Journal

miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway

(2016) JING HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The evolution of cooperation within the gut microbiota

(2016) Seth Rakoff-Nahoum et al.   NATURE

The gut–kidney axis

(2016) Pieter Evenepoel et al.   PEDIATRIC NEPHROLOGY

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

(2016) Emiko Sato et al.   Scientific Reports

Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients

(2016) Jesús Ogando et al.   Scientific Reports

Bioengineered kidney tubules efficiently excrete uremic toxins

(2016) J. Jansen et al.   Scientific Reports

Development of Species-Specific Ah Receptor-Responsive Third Generation CALUX Cell Lines with Enhanced Responsiveness and Improved Detection Limits

(2015) Jennifer C. Brennan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Influence of CKD on Colonic Microbial Metabolism

(2015) R. Poesen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

(2015) Sanjay K. Nigam et al.   PHYSIOLOGICAL REVIEWS

Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway

(2015) Ke Yang et al.   TOXICOLOGY LETTERS

Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations

(2015) J. Jansen et al.   Scientific Reports

Human Urine as a Noninvasive Source of Kidney Cells

(2015) Fanny Oliveira Arcolino et al.   Stem Cells International

The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites

(2015) Ruben Poesen et al.   PLoS One

A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue

(2014) J. Jansen et al.   EXPERIMENTAL CELL RESEARCH

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells

(2014) Yang Lu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Protein-Bound Uremic Toxins Induce Tissue Remodeling by Targeting the EGF Receptor

(2014) C.-Y. Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast Growth Factor 23/Klotho Axis in Chronic Kidney Disease

(2014) Kosaku Nitta et al.   NEPHRON CLINICAL PRACTICE

miRDB: an online resource for microRNA target prediction and functional annotations

(2014) Nathan Wong et al.   NUCLEIC ACIDS RESEARCH

The Kidney and Uremic Toxin Removal: Glomerulus or Tubule?

(2014) Rosalinde Masereeuw et al.   SEMINARS IN NEPHROLOGY

The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease

(2014) Marion Sallée et al.   Toxins

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

The bioartificial kidney: current status and future promise

(2013) H. David Humes et al.   PEDIATRIC NEPHROLOGY

Chronic kidney disease alters intestinal microbial flora

(2012) Nosratola D. Vaziri et al.   KIDNEY INTERNATIONAL

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

The Evolving Role of the Aryl Hydrocarbon Receptor (AHR) in the Normophysiology of Hematopoiesis

(2012) Stephan Lindsey et al.   Stem Cell Reviews and Reports

The performance of primary human renal cells in hollow fiber bioreactors for bioartificial kidneys

(2011) Zay Yar Oo et al.   BIOMATERIALS

Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)

(2011) William R. Wikoff et al.   JOURNAL OF PROTEOME RESEARCH

Remote Communication through Solute Carriers and ATP Binding Cassette Drug Transporter Pathways: An Update on the Remote Sensing and Signaling Hypothesis

(2011) W. Wu et al.   MOLECULAR PHARMACOLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations

(2011) Henricus A. M. Mutsaers et al.   PLoS One

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

(2010) B. K. I. Meijers et al.   Clinical Journal of the American Society of Nephrology

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Epidermal Growth Factor-activated Aryl Hydrocarbon Receptor Nuclear Translocator/HIF-1β Signal Pathway Up-regulates Cyclooxygenase-2 Gene Expression Associated with Squamous Cell Carcinoma

(2009) Kwang-Yu Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis

(2009) S.-Y. Ahn et al.   MOLECULAR PHARMACOLOGY

Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications

(2009) Hideyuki Saito   PHARMACOLOGY & THERAPEUTICS

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA