A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates

Electric-Field-Driven Translocation of ssDNA through Hydrophobic Nanopores

(2018) Taylor Haynes et al.   ACS Nano

Identification and characterization of hydrophobic gate residues in TRP channels

(2018) Wang Zheng et al.   FASEB JOURNAL

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

(2018) Marina A. Kasimova et al.   Journal of Physical Chemistry Letters

Light- and Electric-Field-Controlled Wetting Behavior in Nanochannels for Regulating Nanoconfined Mass Transport

(2018) Ganhua Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

(2018) Wang Zheng et al.   Nature Communications

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hydrophobic gating in BK channels

(2018) Zhiguang Jia et al.   Nature Communications

PoreDesigner for tuning solute selectivity in a robust and highly permeable outer membrane pore

(2018) Ratul Chowdhury et al.   Nature Communications

Structures reveal opening of the store-operated calcium channel Orai

(2018) Xiaowei Hou et al.   eLife

Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor

(2018) Sandip Basak et al.   NATURE

Conformational transitions of the serotonin 5-HT3 receptor

(2018) Lucie Polovinkin et al.   NATURE

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

(2017) Megumi Yamashita et al.   Nature Communications

Functional Annotation of Ion Channel Structures by Molecular Simulation

(2016) Jemma L. Trick et al.   STRUCTURE

Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains

(2016) Anton O. Chugunov et al.   Scientific Reports

Hydrophobic Gating in Ion Channels

(2015) Prafulla Aryal et al.   JOURNAL OF MOLECULAR BIOLOGY

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

(2015) Phillip J. Stansfeld et al.   STRUCTURE

Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA

(2015) Chris Neale et al.   PLoS Computational Biology

Building Predictive Models inRUsing thecaretPackage

(2015) Max Kuhn   Journal of Statistical Software

Designing a Hydrophobic Barrier within Biomimetic Nanopores

(2014) Jemma. L. Trick et al.   ACS Nano

Single particle electron cryo-microscopy of a mammalian ion channel

(2014) Maofu Liao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel

(2014) Prafulla Aryal et al.   Nature Communications

Drying Transition in the Hydrophobic Gate of the GLIC Channel Blocks Ion Conduction

(2012) Fangqiang Zhu et al.   BIOPHYSICAL JOURNAL

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Electric-field-induced wetting and dewetting in single hydrophobic nanopores

(2011) Matthew R. Powell et al.   Nature Nanotechnology

Pore opening and closing of a pentameric ligand-gated ion channel

(2010) F. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of conduction and hydrophobic gating in K+ channels

(2010) M. O. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA