Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

Discovery of Unconventional Kinetochores in Kinetoplastids

(2014) Bungo Akiyoshi et al.   CELL

Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei

(2014) Savitha Kalidas et al.   EUKARYOTIC CELL

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

(2014) Nathaniel G. Jones et al.   PLoS Pathogens

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei

(2014) Sam Alsford et al.   PLoS Pathogens

A Genome-Wide Tethering Screen Reveals Novel Potential Post-Transcriptional Regulators in Trypanosoma brucei

(2014) Esteban D. Erben et al.   PLoS Pathogens

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

(2013) Matthew K. Gould et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation inTrypanosoma brucei

(2013) Gabriela Schumann Burkard et al.   MOLECULAR MICROBIOLOGY

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

(2013) Binny M. Mony et al.   NATURE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

(2013) Fabrice E. Graf et al.   PLoS Neglected Tropical Diseases

High-throughput decoding of antitrypanosomal drug efficacy and resistance

(2012) Sam Alsford et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

(2012) N. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

(2010) Nicola Baker et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters

(2010) Gabriela Schumann Burkard et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Retention and Loss of RNA Interference Pathways in Trypanosomatid Protozoans

(2010) Lon-Fye Lye et al.   PLoS Pathogens

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

(2010) Isabel M. Vincent et al.   PLoS Pathogens

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

(2009) Likun Wang et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants

(2009) G. C. Langridge et al.   GENOME RESEARCH

Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

(2009) Lucy Glover et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids

(2008) David Horn   BMC GENOMICS

Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei

(2008) Sam Alsford et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A large genome center's improvements to the Illumina sequencing system

(2008) Michael A Quail et al.   NATURE METHODS

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

(2008) L. Glover et al.   NUCLEIC ACIDS RESEARCH

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA