Article
Medicine, Research & Experimental
Erin Y. Earnhardt, Jennifer L. Tipper, Adonis D'Mello, Ming -Yuan Jian, Elijah S. Conway, James A. Mobley, Carlos J. Orihuela, Herve Tettelin, Kevin S. Harrod
Summary: Influenza A virus (IAV) infection disrupts airway homeostasis and decreases CFTR function, leading to airway pathophysiology resembling cystic fibrosis. By using human airway organotypic cultures, this study investigates how IAV alters the airway microenvironment to increase susceptibility to secondary Streptococcus pneumoniae (Spn) infection. The researchers found that IAV-induced CFTR dysfunction and airway surface liquid acidification play a central role in increasing susceptibility to Spn, and IAV also induces transcriptional and proteomic changes in the airway epithelium, affecting host defense pathways and epithelial function.
Review
Medicine, General & Internal
Timothy M. Uyeki, David S. Hui, Maria Zambon, David E. Wentworth, Arnold S. Monto
Summary: Seasonal influenza caused by influenza A and B viruses is a significant global burden. Vaccination is the primary prevention measure, but novel influenza viruses still pose pandemic threats.
Article
Microbiology
Kin Kui Lai, James B. B. Munro, Guoli Shi, Saliha Majdoul, Alex A. A. Compton, Alan Rein
Summary: Serine incorporator 5 (Ser5) is a host antiviral factor against HIV-1, gammaretroviruses, and Influenza A virus (IAV). It inhibits virus-cell fusion by interacting with HA proteins and destabilizing the pre-fusion conformation of IAV HA. This study provides insights into the antiviral mechanism of Ser5.
Article
Virology
Pinar Yazici ozkaya, Ese Eda Turanli, Hamdi Metin, Ayca Aydin Uysal, Candan cicek, Bulent Karapinar
Summary: This study aimed to identify the clinical features and mortality associated with severe influenza A and B virus infections in children admitted to the pediatric intensive care unit (PICU) between 2012 and 2019. The study found that although the proportion of influenza A cases admitted to the PICU was higher, the percentage of cases requiring PICU admission was nearly two times higher in influenza B cases. Additionally, there was no statistically significant difference in disease severity and complications in patients with influenza A and influenza B.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Jeremy R. Keown, Zihan Zhu, Loic Carrique, Haitian Fan, Alexander P. Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M. Grimes
Summary: Influenza A viruses cause significant burdens to healthcare systems through seasonal epidemics and global pandemics. The viral RNA-dependent RNA polymerase plays a central role in the replication cycle of influenza viruses and is a potential target for antiviral development. By characterizing the inhibitory effect of nanobodies on the 1918 pandemic influenza virus polymerase complex, sensitive sites interfering with polymerase activity in vitro were identified, suggesting them as effective targets for potential influenza antiviral development.
NATURE COMMUNICATIONS
(2022)
Review
Infectious Diseases
Carsten Kirkeby, Michael P. Ward
Summary: Avian influenza is becoming a growing problem in Europe and worldwide. Simulation models are useful tools for predicting the risk of avian influenza spread and evaluating control measures. Estimates of transmission parameters vary widely based on virus type, pathogenicity, species, study type, and poultry flock unit.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Jingxuan Qiu, Xinxin Tian, Yaxing Liu, Tianyu Lu, Hailong Wang, Zhuochen Shi, Sihao Lu, Dongpo Xu, Tianyi Qiu
Summary: The study introduced a series of structure-based universal models Univ-Flu for HA antigenicity prediction, which showed high prediction performance on different IAV subtypes. The designed descriptors accurately characterized universal antigenicity, providing in-silico reference for vaccine recommendation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Microbiology
Joseph T. Hicks, Kimberly Edwards, Xueting Qiu, Do-Kyun Kim, James E. Hixson, Scott Krauss, Richard J. Webby, Robert G. Webster, Justin Bahl
Summary: This study analyzed AIV genomic sequences from North American wild birds and found that AIV transmission is associated with host genetic relatedness, breeding habitat range overlap, and migratory behaviors. Geographic dispersal is primarily limited by physical distance, while summer temperature has a positive impact on geographic movement rates. Host diversity and ecology play important roles in determining AIV natural history, spread, and emergence risk.
Article
Nutrition & Dietetics
Weimin Guo, Dayong Wu, Lijun Li, Samuel Ding, Simin Nikbin Meydani
Summary: Obesity may contribute to impaired immune function and increased susceptibility to infection.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Michael Welch, Karen Krueger, Jianqiang Zhang, Pablo Pineyro, Abby Patterson, Phillip Gauger
Summary: The objective of this study was to evaluate if PPIV-1 increases the severity of influenza A virus respiratory disease in swine. The study found that PPIV-1 did not appear to influence the severity of clinical disease, macroscopic lesions, or alter viral loads detected in nasal swabs or necropsy tissues when administered as a coinfection with IAV-S.
VETERINARY MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meng Yang, Asigul Ismayil, Zhihao Jiang, Yan Wang, Xiyin Zheng, Liming Yan, Yiguo Hong, Dawei Li, Yule Liu
Summary: The study reveals that the replicase gamma a of Barley stripe mosaic virus can inhibit vacuolar acidification and suppress autophagic degradation to promote viral infection in plants. The disruption of vacuolar acidification seems to be a common viral counter-defense strategy employed by multiple viruses, highlighting the importance of functional vacuolar acidification in plant antiviral defense.
Article
Immunology
Florian Krammer, Stacey Schultz-Cherry
Summary: Recent evidence of avian H5N1 virus transmission among mammals raises concerns about its potential for a pandemic. We need to increase awareness, preparedness, and adopt safe farming practices to prevent the emergence of concerning pathogens in the future.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Auladell, Hoang Vu Mai Phuong, Le Thi Quynh Mai, Yeu-Yang Tseng, Louise Carolan, Sam Wilks, Pham Quang Thai, David Price, Nguyen Thanh Duong, Nguyen Le Khang Hang, Le Thi Thanh, Nguyen Thi Hong Thuong, Tran Thi Kieu Huong, Nguyen Thi Ngoc Diep, Vu Thi Ngoc Bich, Arseniy Khvorov, Luca Hensen, Tran Nhu Duong, Katherine Kedzierska, Dang Duc Anh, Heiman Wertheim, Scott D. Boyd, Kim L. Good-Jacobson, Derek Smith, Ian Barr, Sheena Sullivan, H. Rogier van Doorn, Annette Fox
Summary: Recent prior influenza A infection enhances antibody responses to subsequent influenza vaccination and broadens the reactivity to different strains. Immunological memory induced by prior infection plays an important role in vaccine responses.
Review
Immunology
Claudia Maria Trombetta, Otfried Kistner, Emanuele Montomoli, Simonetta Viviani, Serena Marchi
Summary: Influenza is a vaccine preventable disease and vaccination is the most effective method of controlling the morbidity and mortality of seasonal influenza, especially among risk groups. The effectiveness of current influenza vaccines is suboptimal, but they are still effective against morbidity and mortality in all age and risk groups, particularly in young children and older adults.
Article
Virology
O. P. Zhirnov, P. Chlanda
Summary: The M2 protein of influenza A virus has multiple regulatory roles in infection, showing that even small molecules can have significant impacts in biological processes.