Connections between the cell cycle, cell adhesion and the cytoskeleton

Variation in traction forces during cell cycle progression

(2018) Benoit Vianay et al.   BIOLOGY OF THE CELL

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

(2018) Christina L. Dix et al.   DEVELOPMENTAL CELL

Cell adhesion is regulated by CDK1 during the cell cycle

(2018) Matthew C. Jones et al.   JOURNAL OF CELL BIOLOGY

Regulation of cell cycle progression by cell–cell and cell–matrix forces

(2018) Marina Uroz et al.   NATURE CELL BIOLOGY

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation

(2018) Jiuli Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of the Epithelial Barrier and Remodeling of Cell-Cell Junctions during Cytokinesis

(2016) Tomohito Higashi et al.   CURRENT BIOLOGY

Mechanosensing in cell–matrix adhesions – Converting tension into chemical signals

(2016) Vesa P. Hytönen et al.   EXPERIMENTAL CELL RESEARCH

Mechanosensing via cell-matrix adhesions in 3D microenvironments

(2016) Andrew D. Doyle et al.   EXPERIMENTAL CELL RESEARCH

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast

(2016) Yansong Miao et al.   Nature Communications

A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

(2016) Nicoletta I. Petridou et al.   Nature Communications

Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody

(2016) Siamak A. Kamranvar et al.   Oncotarget

Focal adhesions control cleavage furrow shape and spindle tilt during mitosis

(2016) Nilay Taneja et al.   Scientific Reports

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression

(2015) J. Lee et al.   CLINICAL CANCER RESEARCH

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Patterned Anchorage to the Apical Extracellular Matrix Defines Tissue Shape in the Developing Appendages of Drosophila

(2015) Robert P. Ray et al.   DEVELOPMENTAL CELL

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein

(2015) Yuji Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells

(2015) Elaina B. Breznau et al.   MOLECULAR BIOLOGY OF THE CELL

Transglutaminase is a tumor cell and cancer stem cell survival factor

(2015) Richard L. Eckert et al.   MOLECULAR CARCINOGENESIS

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement

(2015) Subramanian P. Ramanathan et al.   NATURE CELL BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Stromal contribution to the colorectal cancer transcriptome

(2015) Claudio Isella et al.   NATURE GENETICS

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

(2015) R Navab et al.   ONCOGENE

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

(2015) Adam Byron et al.   Nature Communications

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Microtubules Regulate Focal Adhesion Dynamics through MAP4K4

(2014) Jiping Yue et al.   DEVELOPMENTAL CELL

Exploring the Function of Cell Shape and Size during Mitosis

(2014) Clotilde Cadart et al.   DEVELOPMENTAL CELL

DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis

(2014) Stefano Marchesi et al.   DEVELOPMENTAL CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration

(2014) Natalia Schiefermeier et al.   JOURNAL OF CELL BIOLOGY

Contractile forces regulate cell division in three-dimensional environments

(2014) Ayelet Lesman et al.   JOURNAL OF CELL BIOLOGY

Rolled-up Functionalized Nanomembranes as Three-Dimensional Cavities for Single Cell Studies

(2014) Wang Xi et al.   NANO LETTERS

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-Dependent Modulation of Adhesion Complex Composition

(2014) Daniel H. J. Ng et al.   PLoS One

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

(2014) Y. H. Bae et al.   Science Signaling

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

(2014) I. M. Shapiro et al.   Science Translational Medicine

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

Shaping up to divide: Coordinating actin and microtubule cytoskeletal remodelling during mitosis

(2014) Oscar M. Lancaster et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

LIM proteins in actin cytoskeleton mechanoresponse

(2014) M.A. Smith et al.   TRENDS IN CELL BIOLOGY

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis

(2014) Nicoletta I. Petridou et al.   Nature Communications

Cell Adhesion Geometry Regulates Non-Random DNA Segregation and Asymmetric Cell Fates in Mouse Skeletal Muscle Stem Cells

(2014) Siham Yennek et al.   Cell Reports

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma

(2014) Syed Haider et al.   Genome Medicine

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

Deciphering the role of stroma in pancreatic cancer

(2013) Meghna Waghray et al.   CURRENT OPINION IN GASTROENTEROLOGY

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Mitotic Rounding Alters Cell Geometry to Ensure Efficient Bipolar Spindle Formation

(2013) Oscar M. Lancaster et al.   DEVELOPMENTAL CELL

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

Integrins promote cytokinesis through the RSK signaling axis

(2013) S. S. Mathew et al.   JOURNAL OF CELL SCIENCE

Signalling pathways linking integrins with cell cycle progression

(2013) Paulina Moreno-Layseca et al.   MATRIX BIOLOGY

Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions

(2013) Fang Kong et al.   MOLECULAR CELL

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Cell-cycle regulation of formin-mediated actin cable assembly

(2013) Y. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Changes in Ect2 Localization Couple Actomyosin-Dependent Cell Shape Changes to Mitotic Progression

(2012) Helen K. Matthews et al.   DEVELOPMENTAL CELL

Crosstalk between TGF-β and hedgehog signaling in cancer

(2012) Delphine Javelaud et al.   FEBS LETTERS

Improving drug delivery to pancreatic cancer: breaching the stromal fortress by targeting hyaluronic acid

(2012) Patrick Michl et al.   GUT

A novel function for Cyclin A2: Control of cell invasion via RhoA signaling

(2012) Nikola Arsic et al.   JOURNAL OF CELL BIOLOGY

A functional genetic screen reveals new regulators of  1-integrin activity

(2012) T. Pellinen et al.   JOURNAL OF CELL SCIENCE

Molecular control of animal cell cytokinesis

(2012) Juan Pablo Fededa et al.   NATURE CELL BIOLOGY

The LIM Domain of Zyxin Is Sufficient for Force-Induced Accumulation of Zyxin During Cell Migration

(2011) Arisa Uemura et al.   BIOPHYSICAL JOURNAL

Tissue Biomarkers for Prognosis in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis

(2011) N. B. Jamieson et al.   CLINICAL CANCER RESEARCH

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

The C terminus of talin links integrins to cell cycle progression

(2011) Pengbo Wang et al.   JOURNAL OF CELL BIOLOGY

The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

(2011) Ann-Marie Baker et al.   JNCI-Journal of the National Cancer Institute

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo

(2011) G Högnäs et al.   ONCOGENE

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair

(2010) Mark A. Smith et al.   DEVELOPMENTAL CELL

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Mammographic density and the risk of breast cancer recurrence after breast-conserving surgery

(2009) Tulin Cil et al.   CANCER

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells

(2009) Ling Su et al.   EXPERIMENTAL CELL RESEARCH

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis

(2009) V. T. Dao et al.   JOURNAL OF CELL SCIENCE

Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics

(2009) E. J. Arnsdorf et al.   JOURNAL OF CELL SCIENCE

Filamin A–β1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension

(2009) Scott Gehler et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

The actin cytoskeleton in spindle assembly and positioning

(2009) Patricia Kunda et al.   TRENDS IN CELL BIOLOGY

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology

Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis

(2008) Patricia Kunda et al.   CURRENT BIOLOGY

Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos

(2008) Anna Bielak-Zmijewska et al.   DEVELOPMENTAL BIOLOGY

Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis

(2008) Teijo Pellinen et al.   DEVELOPMENTAL CELL

ECM Compliance Regulates Osteogenesis by Influencing MAPK Signaling Downstream of RhoA and ROCK

(2008) Chirag B Khatiwala et al.   JOURNAL OF BONE AND MINERAL RESEARCH

G1/S Cyclin-dependent Kinase Regulates Small GTPase Rho1p through Phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae

(2008) Keiko Kono et al.   MOLECULAR BIOLOGY OF THE CELL

mDia2 Induces the Actin Scaffold for the Contractile Ring and Stabilizes Its Position during Cytokinesis in NIH 3T3 Cells

(2008) Sadanori Watanabe et al.   MOLECULAR BIOLOGY OF THE CELL

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

The Septins Function in G1 Pathways that Influence the Pattern of Cell Growth in Budding Yeast

(2008) Thea A. Egelhofer et al.   PLoS One

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

(2008) J. D. Blethrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA